Three New <i>ent</i>‐Kaurane Diterpenoids from <i>Siegesbeckia pubescens</i>

Jia, Liu; Feng, Lei; Li, Hai-Dao; Dong, Qingli; Chen, Rong

doi:10.1002/hlca.201100272

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…X-Ray crystallographic studies of atractyloside which is the toxic constituent of the thistle, Atractylis gummifera, have been reported. 110,111 Glycosides of 4-epiatractyligenin have been obtained 112 from Siegesbeckia pubescens (Asteraceae). This plant is known in Chinese traditional medicine as xixian and is used for the treatment of arthritis and other inammatory conditions.…”

Section: Tetracyclic Diterpenesmentioning

confidence: 99%

Diterpenoids of terrestrial origin

Hanson

2013

Nat. Prod. Rep.

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Section: Tetracyclic Diterpenesmentioning

confidence: 99%

Diterpenoids of terrestrial origin

Hanson

2013

Nat. Prod. Rep.

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“…Seven known diterpenoids were also obtained from this genus, bengalensol [18], villanovane [10], tricalysione A [14], 2 β ,16 α ,17-trihydroxy- ent -kauran-19 α -oic acid [19], 2-O-(2-O-isovaleryl- β - d -gluco-pyranosyl)-4 α -atractyligenin [20], 2-O-(2-O-isovaleryl- β - d -gluco-pyranosyl)-4 β -atrac- tyligenin [20], 3-O- β - d -glucopyranosyl-2-O-(2-O-isovaleryl- β - d -gluco-pyranosyl)-4 β -atracty ligenin [20]. Their structures were identified by comparison of their NMR data with literature data.…”

Section: Resultsmentioning

confidence: 99%

Characterization of New Ent-kaurane Diterpenoids of Yunnan Arabica Coffee Beans

Chu

Wan

Peng

et al. 2016

Nat. Prod. Bioprospect.

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Five new ent-kaurane diterpenoids, named mascaroside III–V (1–3), and 20-nor-cofaryloside I–II (4–5), together with seven known diterpenoids, were isolated from methanol extracts of the green coffee beans of Yunnan Arabica Coffee. Their chemical structures were elucidated by extensive spectroscopic analyses. Meanwhile, cytotoxicity assay against HL-60, A-549, SMMC-7721, MCF-7 and SW480 cell lines showed that they have not evident inhibition of cytotoxicity.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0099-1) contains supplementary material, which is available to authorized users.

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Rapid extraction and analysis method for the simultaneous determination of 21 bioflavonoids in Siegesbeckia pubescens Makino

Yao

Liang

Sun

et al. 2015

J of Separation Science

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A novel and rapid microwave extraction and ultra high performance liquid chromatography coupled with a triple quadrupole-linear ion trap mass spectrometry method was developed and validated for the determination of 21 bioflavonoids in Siegesbeckia pubescens Makino. The optimal conditions for the extraction of flavonoids from Siegesbeckia pubescens Makino involved the use of methanol as the extraction solvent, a microwave temperature of 70°C, an extraction time of 11 min, and a solvent-to-solid ratio of 40 mL/g. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C18 column(100 × 2.1 mm, 1.7 μm) with a gradient mobile phase (A: 0.3% v/v aqueous formic acid and B: acetonitrile) at a flow rate of 0.25 mL/min. All calibration curves showed good linearity (r > 0.999) within the test ranges. The method developed was validated with acceptable sensitivity, intra- and interday precision, reproducibility, and extraction recoveries. The validated method was successfully applied to determine the contents of 21 bioflavonoids in Siegesbeckia pubescens Makino from different sources.

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Three New ent‐Kaurane Diterpenoids from Siegesbeckia pubescens

Abstract: (4), were isolated for the first time from the aerial parts of Siegesbeckia pubescens. The structures were established by extensive spectroscopic analyses including 1D-and 2D-NMR (HSQC, HMBC, and ROESY), and HR-ESI-MS, and by comparison with published data.

Cited by 8 publications

References 6 publications

Diterpenoids of terrestrial origin

Diterpenoids of terrestrial origin

Characterization of New Ent-kaurane Diterpenoids of Yunnan Arabica Coffee Beans

Rapid extraction and analysis method for the simultaneous determination of 21 bioflavonoids in Siegesbeckia pubescens Makino

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