Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp . SCSIO41007

Pang, Xiaoyan; Lin, Xiuping; Wang, Junfeng; Liang, Ruixing; Tian, Yongtao; Salendra, Limbadri; Luo, Xiaowei; Zhou, Xuefeng; Yang, Bin; Tu, Zhengchao; Liu, Yonghong

doi:10.1016/j.steroids.2017.12.001

Cited by 28 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 ) was a new highly oxygenated sterol that was obtained from the extracts of the culture of a sponge-derived fungus Cladosporium sp. SCSIO41007 collected from the sea area near Xuwen County, Guangdong Province, China [ 45 ]. Compound 37 showed weak anti-H 3 N 2 activity with IC 50 value of 16.2 μM (IC 50 = 34.0 nM for the positive control oseltamivir) [ 45 ].…”

Section: Potential Anti-virus Agents From Marine Microbesmentioning

confidence: 99%

“…SCSIO41007 collected from the sea area near Xuwen County, Guangdong Province, China [ 45 ]. Compound 37 showed weak anti-H 3 N 2 activity with IC 50 value of 16.2 μM (IC 50 = 34.0 nM for the positive control oseltamivir) [ 45 ]. The fungal strain Aspergillus ochraceus Jcma1F17 was isolated from a marine algae Coelarthrum sp.…”

Section: Potential Anti-virus Agents From Marine Microbesmentioning

confidence: 99%

“…(H 1 N 1 and H 3 N 2 virus) [ 44 ] Cladosporisteroid B ( 37 ) Cladosporium sp. SCSIO41007 IC 50 = 16.2 μM (H 3 N 2 virus) [ 45 ] 6 β ,9 α -dihydroxy-14- p -nitrobenzoylcinnamolide ( 38 ) A. ochraceus Jcma1F17 IC 50 = 17.0 μM (H 3 N 2 virus) [ 46 ] …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antiviral potential of natural products from marine microbes

Lin

Zhang

et al. 2020

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

Humans have been suffered from viral infections over the centuries, such as influenza, HSV, and HIV, which have killed millions of people worldwide. However, the availability of effective treatments for infectious diseases remains limited until now, as most of the viral pathogens resisted to many medical treatments. Marine microbes are currently one of the most copious sources of pharmacologically active natural products, which have constantly provided promising antivirus agents. To date, a large number of marine microbial secondary metabolites with antiviral activities have been widely reported. In this review, we have summarized the potential antivirus compounds from marine microorganisms over the last decade. In addition, the structures, bioactivities, and origins of these compounds were discussed as well.

show abstract

Section: Potential Anti-virus Agents From Marine Microbesmentioning

confidence: 99%

Section: Potential Anti-virus Agents From Marine Microbesmentioning

confidence: 99%

See 1 more Smart Citation

Antiviral potential of natural products from marine microbes

Lin

Zhang

et al. 2020

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…Compound 73 showed antiviral activity against the respiratory syncytial virus (RSV) with the IC 50 value of 0.12 µM. Cladosporisteroid B ( 74 ) (Pang et al 2018 ), a highly oxygenated sterol, was also isolated from the culture extracts of sponge-derived fungus Cladosporium sp. and exhibited weak inhibitory activity against H3N2 with an IC 50 value of 16.2 µM.…”

Section: Marine Microbial-derived Antiviral Compoundsmentioning

confidence: 99%

Recent progresses in marine microbial-derived antiviral natural products

Teng

Wei

et al. 2020

Arch. Pharm. Res.

View full text Add to dashboard Cite

“…Sponge-derived fungi are one of the richest sources of many structurally unique and biologically active secondary metabolites among marine sources [8]. As part of our ongoing research for bioactive natural products from sponge-derived fungi [9,10,11,12,13], the fungus Alternaria sp. SCSIO41014 was studied.…”

Section: Introductionmentioning

confidence: 99%

Perylenequione Derivatives with Anticancer Activities Isolated from the Marine Sponge-Derived Fungus, Alternaria sp. SCSIO41014

et al. 2018

Self Cite

View full text Add to dashboard Cite

Seven new secondary metabolites classified as two perylenequinone derivatives (1 and 2), an altenusin derivative (3), two phthalide racemates (4 and 5), and two phenol derivatives (6 and 7), along with twenty-one known compounds (8–28) were isolated from cultures of the sponge-derived fungus, Alternaria sp. SCSIO41014. The structures and absolute configurations of these new compounds (1–7) were determined by spectroscopic analysis, X-ray single crystal diffraction, chiral-phase HPLC separation, and comparison of ECD spectra to calculations. Altertoxin VII (1) is the first example possessing a novel 4,8-dihydroxy-substituted perylenequinone derivative, while the phenolic hydroxy groups have commonly always substituted at C-4 and C-9. Compound 1 exhibited cytotoxic activities against human erythroleukemia (K562), human gastric carcinoma cells (SGC-7901), and hepatocellular carcinoma cells (BEL-7402) with IC50 values of 26.58 ± 0.80, 8.75 ± 0.13, and 13.11 ± 0.95 μg/mL, respectively. Compound 11 showed selectively cytotoxic activity against K562, with an IC50 value of 19.67 ± 0.19 μg/mL. Compound 25 displayed moderate inhibitory activity against Staphylococcus aureus with an MIC value of 31.25 μg/mL.

show abstract

Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp . SCSIO41007

Cited by 28 publications

References 17 publications

Antiviral potential of natural products from marine microbes

Antiviral potential of natural products from marine microbes

Recent progresses in marine microbial-derived antiviral natural products

Perylenequione Derivatives with Anticancer Activities Isolated from the Marine Sponge-Derived Fungus, Alternaria sp. SCSIO41014

Contact Info

Product

Resources

About