Three new diterpenoids from the leaves of <i>Salvia lachnostachys</i>

Oliveira, Cristhian Santos; Alvarez, Carlos José; Cabral, Márcia Regina Pereira; Sarragiotto, María Helena; Salvador, Marcos José; Stefanello, Maria Élida Alves

doi:10.1080/14786419.2021.2022668

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…Salvia lachnostachys Benth (Lamiaceae) is a herb native of Brazil. Its ethanolic extract from leaves (SLE) contains several triterpenes and diterpenes, among them, fruticuline A (21, Figure 15), a norabietane diterpenoid, emerged for its anti-inflammatory (paw edema and pleurisy induced by carrageenan injection) and antihyperalgesic effects [148,149]. Crude SLE contains about 3% of fruticuline A (21).…”

Section: Fruticuline Amentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their use. As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. Among them, natural products are known to be a rich source of lead compounds for drug discovery due to their chemical structural variety and different analgesic mechanisms. Numerous studies suggested that some chemicals from medicinal plants could be alternative options for pain relief and management. Previously, we conducted a literature search aimed at identifying natural products interacting either directly or indirectly with opioid receptors. In this review, instead, we have made an excursus including active ingredients derived from plants whose mechanism of action appears from the literature to be other than the modulation of the opioid system. These substances could, either by themselves or through synthetic and/or semi-synthetic derivatives, be investigated in order to improve their pharmacokinetic characteristics and could represent a valid alternative to the opioid approach to pain therapy. They could also be the basis for the study of new mechanisms of action in the approach to this complex and disabling pathology.

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Section: Fruticuline Amentioning

confidence: 99%

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Turnaturi,

Piana,

Spoto

et al. 2024

Molecules

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“…The icetexanes discovered to date vary widely in the degree of oxygenation and oxidation in each ring, resulting in a range of structures and biological activities [32]. Fruticuline A and demethylfruticuline A have shown potent antibacterial activity against Gram-positive bacteria [130,131], and antioxidant activity [132]. Fruticuline A has also been reported to have anti-inflammatory and analgesic properties [133].…”

Section: Icetexane Diterpenoids: Demethylfruticuline a And Fruticuline Amentioning

confidence: 99%

Salvia Species: Biotechnological Strategies Applied to In Vitro Cultures for the Controlled Production of Bioactive Diterpenoids

Dougué Kentsop,

Devi,

Copetta

et al. 2024

Agronomy

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Plant secondary metabolites have great applications in the nutritional and cosmetic aspects of human health. Terpenes, and in particular bioactive diterpenoids, represent an important group of compounds found in Salvia species. Their production in plants is often limited, and chemical synthesis is often not economically feasible. Biotechnological approaches using plant cell and tissue cultures can be routinely established under sterile conditions from explants for biomass production and the extraction of secondary metabolites. The biosynthesis and accumulation of bioactive diterpenoids in vitro in Salvia cells and tissues can be enhanced by strain improvement, techniques to select high-producing cell lines, optimisation of the growth medium, use of specific precursors or elicitors, induction of their release into the culture medium, and the overexpression of genes. This review analyses the biotechnological techniques applied to the in vitro culture of Salvia cells and tissues to enhance the production and accumulation of bioactive diterpenoids and summarises their biological activities.

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“…The essential oil from the flowers and leaves of S. lachnostachys has saturated aliphatic compounds and a sesquiterpene fraction [ 4 ]. Diterpenes, triterpenes, and rosmarinic acid were isolated from the ethanolic extract of the leaves [ 5 , 6 ]. The chromatographic profile of the ethanolic extract also was obtained by HPLC [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in the literature, S. lachnostachys extract was characterized as chemopreventive and antitumor in Ehrlich models [ 7 ] and fruticulin A as antineoplastic in vitro and in vivo models [ 11 ]. Four diterpenes (fructiculine A, demethylfruticuline A, fruticuline B, and demethylfruticuline B) showed antioxidant activity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential

Ortiz

Neves

Kassuya

et al. 2023

BMC Complement Med Ther

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Salvia lachnostachys Benth is native to Brazil and has anti-inflammatory, anti-arthritic, cytotoxic, antitumor, and antihyperalgesic activities. The population, including pregnant women, consume this plant to treat pain, inflammation, flu, spasms, insomnia, and depression, mainly. There are no safety reports on the use of this plant during pregnancy. The present study aimed to evaluate the effects of S. lachnostachys ethanolic extract (EESl) on reproductive performance, embryofetal development, and DNA integrity of pregnant female mice. Pregnant females were randomly divided into three experimental groups (n = 10): The Control group was treated with a vehicle, and treatment groups were administered with EESl at 100 and 1000 mg/kg, respectively. Treatment occurred by gavage throughout the gestational period until day 18. Afterward, reproductive performance, embryofetal development, and DNA integrity parameters were evaluated. The results indicated that EESl did not alter any reproductive performance parameters. However, it changed embryofetal outcome through reduced placental weight (EESl 100 mg/kg), decreased fetal weight (EESl 100 and 1000 mg/kg), and increased frequency of small for gestational age fetuses (EESl 1000 mg/kg). In addition, EES1 increased the frequency of external, visceral, and skeletal malformations. Because of the above, it is considered that EESl is not maternotoxic, does not alter reproductive performance, but does alter embryofetal development. Its use in the gestational period is not indicated due to its teratogenic potential.

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Three new diterpenoids from the leaves of Salvia lachnostachys

Cited by 7 publications

References 14 publications

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design

Salvia Species: Biotechnological Strategies Applied to In Vitro Cultures for the Controlled Production of Bioactive Diterpenoids

The ethanolic extract of Salvia lachnostachys Benth is not maternotoxic, does not alter reproductive performance, but has teratogenic potential

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