Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus <i>Phomopsis fukushii</i>

Gao, Yu‐Hong; Zheng, Rui; Li, Jing; Kong, Wei-Song; Liu, Xin; Ye, Lin; Mi, Qi-Li; Zhou, Min; Yang, Guangyu; Hu, Qiu‐Fen; Du, Gang; Yang, Haiying; Li, Xuemei

doi:10.1080/10286020.2017.1421177

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…yunna-nensis. Compounds 11-13, exhibited potent anti-MRSA activity, with 20.2, 17.9 and 15.2 mm inhibition zones, respectively, when tested at 50 µg concentration in 6 mm discs [23].…”

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

“…The fungus Diporthe vochysiae LGMF1583 isolated from Vochysia divergens yielded two new carboxamides, vochysiamides A (23), and B (24, Figure 2). Compound 24 inhibited Klebsiella pneumoniae carbapenemase-producing (KPC), MSSA, and MRSA with MIC of 0.08, 1.0, and 1.0 µg/mL, respectively, and compound 23 was active against KPC with a MIC of 1.0 µg/mL.…”

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

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Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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“…yunna-nensis. Compounds 11-13, exhibited potent anti-MRSA activity, with 20.2, 17.9 and 15.2 mm inhibition zones, respectively, when tested at 50 µg concentration in 6 mm discs [23].…”

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…Diphenyl ethers have been reported to possess significant antibacterial activity, especially against Gram-positive bacteria, − and structure–activity relationship analysis showed that prenylation might play an important role to increase antibacterial activity of the compounds. The isopentenyl flavonoids displayed antibacterial activity against Gram-positive pathogens with multidrug-resistance, which may be due to compounds interacting with the phospholipids of the bacterial membrane, dissipating the proton motive force, and degrading membrane permeability .…”

Section: Resultsmentioning

confidence: 99%

“…From this ecological aspect, endophytic fungi are an important source of antibacterial substances, especially as a source of compounds active against MDR bacteria . In recent years, more and more diphenyl ether derivatives have been isolated from plant endophytic fungi and have attracted special attention due to their excellent antibacterial activity. − …”

mentioning

confidence: 99%

Diphenyl Ether Derivative Rhexocerins and Rhexocercosporins from the Endophytic Fungus Rhexocercosporidium sp. Dzf14 Active against Gram-Positive Bacteria with Multidrug-Resistance

Gong

et al. 2023

J. Nat. Prod.

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Ten new diphenyl ether polyketides, including rhexocerins A−D (1−4) and rhexocercosporins A−F (5−10), together with three known congeners (11−13), were isolated from the endophytic fungus Rhexocercosporidium sp. Dzf14 obtained from Dioscorea zingiberensis. Their structures were elucidated by analysis of NMR and HRESIMS data, and their absolute configurations were determined by quantum chemical ECD calculations and X-ray crystallography. Compounds 1−4 featured an unprecedented tetracyclic carbon skeleton (6/7/5/6). Among them, compounds 1 and 5−9 showed antibacterial activities against methicillin-resistant S. aureus T144 and vancomycin-resistant E. faecalis 10.

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“…Antibiotic resistance is an important issue due to the frequent use of antibiotics for the treatment of common bacterial infections. The enhancement of antimicrobial resistance is Antibiotics 2023, 12, 1201 2 of 15 strengthening the pathogenicity and virulence of infectious microbes [1][2][3]. Therefore, finding new antibiotics is crucial to combat these resistant bacteria [4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis

Eshboev,

Karakozova,

Abdurakhmanov

et al. 2023

Antibiotics

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According to the World Health Organization, it is estimated that by 2050, drug-resistant infections could cause up to 10 million deaths annually. Therefore, finding a new generation of antibiotics is crucial. Natural compounds from endophytic fungi are considered a potential source of new-generation antibiotics. The antimicrobial and cytotoxic effects of ethyl acetate extracts of nine endophytic fungal isolates obtained from Hyssopus officinalis were investigated for bioassay-guided isolation of the natural compounds. An extract of isolate VII showed the highest antimicrobial activities against Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus (30.12 ± 0.20 mm and 35.21 ± 0.20 mm) and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa (30.41 ± 0.23 mm and 25.12 ± 0.25 mm) among the tested extracts of isolates. Molecular identification of isolate VII confirmed it as Chaetomium elatum based on sequencing of its ITS genes, and it was discovered that this was the first time C. elatum had been isolated from H. officinalis. This isolate was cultured at a large scale for the isolation and identification of the active compound. Penicillic acid was isolated for the first time from C. elatum and its chemical structure was established by NMR spectroscopy. The penicillic acid showed strong antibacterial activities against Bacillus subtilis and Staphylococcus aureus with 20.68 mm and 25.51 mm inhibition zones, respectively. In addition, MIC and MBC values and antibiofilm activities of penicillic acid were determined. It was found that penicillic acid reduced the level of biofilms in proportion to antibacterial activity.

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Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii

Cited by 9 publications

References 15 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Diphenyl Ether Derivative Rhexocerins and Rhexocercosporins from the Endophytic Fungus Rhexocercosporidium sp. Dzf14 Active against Gram-Positive Bacteria with Multidrug-Resistance

Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis

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