Three new caryophyllene-type sesquiterpenoid glycosides from Biebersteinia heterostemon maxim

Abstract

Three new caryophyllene-type sesquiterpenoid glycosides were isolated from Biebersteinia heterostemon. Their structures were elucidated by comprehensive analysis of NMR and MS spectroscopic data. All the isolated compounds were evaluated for MCF-7/TAM cytotoxic activity. The results indicated that compound 1 was found to exhibit the weak cytotoxicity against MCF-7/TAM with the IC50 value of 106.4±0.04 μM.