Three New C₁₉‐Diterpenoid Alkaloids from Aconitum forrestii

Abstract

A further study of the alkaloid constituents of Aconitum forrestii led to the isolation of three new C19‐diterpenoid alkaloids, named 14‐acetoxy‐8‐O‐methylsachaconitine (1), 14‐acetoxyscaconine (2), and 8‐O‐ethylcammaconine (3). Their structures were determined by UV, IR, and MS, 1D‐ and 2D‐NMR analyses.

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

“…Due to the ester-group presence on C8 and sometimes on C14, they exhibit acute toxicity [ 1 , 3 , 8 ]. Several aconitines lack oxygenated groups on C15 and C6 ( 22–40 ) and rarely arrange a hydroxyl group on C1 as compound 22 [ 2 , 3 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”

Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua

“…As part of an effort to search plant-derived chemicals with potential use as botanical pesticides (insecticides, antifeedants, and growth inhibitors), the extracts from A. apetalum were studied. Seven new C 19 -diterpenoid alkaloids, apetaldines A−G (1−7) (Figure 1), and 10 known alkaloids, talassicumine A (8), 15 aconorine (9), 15 acobretine E (10), 16 cammaconine (11), 15 8-O-ethylcammaconine (12), 17 3-deoxyaconitine (13), 18 aconitine (14), 18 taurenine (15), 19 songorine (16), 14 and songomine (17), 20 were isolated from the roots of A. apetalum. Based on the results of a previous investigation, 21 five compounds were determined to be chasmaconitine (18), chasmanthinine (19), talatisamine (20), indaconitine (24), and leueandine (25) by matching the spectroscopic data among 11 known diterpenoid alkaloids isolated from A. f ranchetii var.…”

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

“…media and S. salicifolia, the other species have not been analysed previously (Table 8). (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). To understand the role of esterifying fatty acids, five fatty acids were screened.…”

“…However, a significant difference between the activity of lipo-alkaloids (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46), aconitine (18) and free fatty acids (Fig 12) indicates that the 14-BzA-part of the molecule is necessary for the ion channel inhibitory effect (Fig 13). Further structure-activity relationship was recognised concerning the saturation grade of the esterifying fatty acids.…”

“…(1, 13)[263]). Lipo-alkaloids(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) were yielded by semisynthesis[83,84]. The purity (≥95%) of the isolated compounds was confirmed by HPLC and 1 H NMR spectroscopy.…”