Three new basidiomycetous yeasts, Pseudozyma alboarmeniaca sp. nov., Pseudozyma crassa sp. nov. and Pseudozyma siamensis sp. nov. isolated from Thai patients

Mekha, Nanthawan; Takashima, Masako; Boon-Long, Jotika; Cho, Otomi; Sugita, Takashi

doi:10.1111/1348-0421.12111

Cited by 17 publications

(12 citation statements)

References 18 publications

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“…Non‐ aphidis Pseudozyma spp. seemed to have susceptibility to amphotericin B only . In all reported cases, Pseudozyma spp.…”

Section: Discussionmentioning

confidence: 82%

“…We retrospectively reviewed the global literature to identify the possible risk factors, clinical presentation, and optimal treatment strategies for Pseudozyma infection; in addition to the present case, 14 case reports were found (Table ) . Since 2014 when previous literature review was reported by Prakash et al .…”

Section: Discussionmentioning

confidence: 99%

“…from Thailand. Of the nine cases with reported underlying medical conditions, three had gastrointestinal (GI) tract problems such as short bowel syndrome or intestinal surgery, and three had neutropenia which can damage the gut mucosa. Of the seven patients for whom the presence or absence of a central venous catheter (CVC) was reported, six patients had a CVC.…”

Section: Discussionmentioning

confidence: 99%

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Pseudozyma aphidis fungaemia with invasive fungal pneumonia in a patient with acute myeloid leukaemia: case report and literature review

Joo

Choi

Cho

et al. 2015

Mycoses

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Summary Pseudozyma species rarely cause invasive diseases in humans, which are usually isolated from plants. There have been anecdotal reports regarding Pseudozyma species infections in patients with underlying diseases or in neonates. However, clinical data and the pathogenicity in humans are still insufficient. We experienced a case of Pseudozyma aphidis fungaemia with invasive fungal pneumonia that developed during reinduction chemotherapy in a 51‐year‐old male with acute myeloid leukaemia (AML). P. aphidis was suspected based on the morphology of the yeast isolated from the blood and was confirmed via rDNA gene sequencing analysis. The patient successfully underwent stem cell transplantation with continuing antifungal treatment and finally completely recovered from both the AML and infectious complications. Here, we report a case of P. aphidis infection that developed during neutropenia in an AML patient and review the global literature.

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“…Non‐ aphidis Pseudozyma spp. seemed to have susceptibility to amphotericin B only . In all reported cases, Pseudozyma spp.…”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pseudozyma aphidis fungaemia with invasive fungal pneumonia in a patient with acute myeloid leukaemia: case report and literature review

Joo

Choi

Cho

et al. 2015

Mycoses

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“…nov., and Pseudozyma siamensis sp. nov.) from blood of Thai patients (16). According to this, P. aphidis seems to be the Pseudozyma species most frequently isolated from human samples.…”

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confidence: 83%

First Case of Fungemia Due to Pseudozyma aphidis in a Pediatric Patient with Osteosarcoma in Latin America

et al. 2015

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We report the first case of blood infection due to Pseudozyma aphidis in Latin America. We contribute evidence showing this organism to be a potential human pathogen, and we provide new data about its identification, drug susceptibility, and treatment outcome. CASE REPORTA 6-year-old female from Córdoba, Argentina, was diagnosed with osteosarcoma of the left tibia and lung metastasis and started chemotherapy administered through a long-term indwelling central line (a central venous catheter [CVC]) on 2 September 2013 at the Hospital de niños de la Santísima Trinidad. On 2 October, she presented with febrile neutropenia and was empirically treated with ceftazidime, vancomycin, and amikacin; blood and urine samples were submitted for laboratory testing, and both cultures were negative. On 4 October, she received clindamycin due to facial edema. From 6 October to 13 November, she was transfused with platelets and red blood cells several times due to thrombocytopenia and anemia. On 5 November, she developed severe mucositis and erythroderma and was treated with ceftazidime, nystatin, amikacin, vancomycin, and fluconazole. On 13 November, she received a 1-week treatment with meropenem and liposomal amphotericin B. On 18 November, she developed conjunctival hyperemia and was treated with tobramycin. On 28 November, she underwent supracondylar amputation of the left lower limb. On 20 December, the patient presented with febrile neutropenia (white blood cells [WBCs], 1,030/mm 3 ) and was admitted to the intensive care unit (ICU) in the same hospital. Table 1 summarizes the clinical data and evolution of the case since admission. A blood sample (BS1) obtained by venipuncture and a hub blood sample (drawn through the catheter hub) (HBS1) were taken and sent to the microbiology laboratory. Yeast cells (Pseudozyma aphidis; isolate Y1) were detected in the hub blood sample after 2.6 days of incubation in a Bact/ALERT PF (bioMérieux Inc., Durham, NC). However, the patient did not show clinical signs of illness on day 3 after admission; therefore, the isolate was considered not significant and she was discharged. Four days later, the patient presented with vomiting, dehydration, and febrile neutropenia (WBCs, 200/mm 3 ) and was admitted once again at the ICU in the same institution. At that point, an empirical antibiotic treatment with ceftazidime and amikacin was initiated and a new blood sample and hub blood sample (BS2 and HBS2) were taken and processed. After 18 h of incubation, both cultures were positive for Pseudomonas aeruginosa. Four days after readmission, the patient presented with fever and severe neutropenia (WBCs, 80/ mm 3 ) and showed high (233 mg/liter) C-reactive protein levels. A blood sample and a hub blood sample (BS3 and HBS3) were taken and processed. After 12 h of incubation, the blood sample culture was positive for Escherichia coli, and 2 h later, the hub blood sample culture was positive for yeast (Y2). This isolate (Y2) had the same phenotypic features as the first yeast isolate (Y1). Six days after...

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“…This genus has been isolated from different types of materials such as leaves (Golubev et al 2007, Chamnanpa et al 2013, flowers (Wei et al 2005, Liou et al 2009), blood samples (Sugita et al 2003, Mekha et al 2014) and even associated with coral reefs and insects (Henninger & Windisch 1975, StatzellTallman et al 2010, Oliveira et al 2014. Pseudozyma aphidis (Henninger & Windisch) Boekhout was firstly described as Sterigmatomyces aphidis Henninger & Windisch in Germany and isolated from Aphididae secretions on leaves of Solanum pseudocapsieum (Henninger & Windisch 1975).…”

Section: Introductionmentioning

confidence: 99%

Molecular identification of Pseudozyma aphidis (Henninger & Windisch) Boekhout: first record from a Brazilian mangrove swamp

Boro

Jesus

Souza

et al. 2017

Hoehnea

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-(Molecular identification of Pseudozyma aphidis (Henninger & Windisch) Boekhout: first record from a Brazilian mangrove swamp). Pseudozyma aphidis (Henninger & Windisch) Boekhout is an anamorph yeast-like basidiomycete commonly found as saprotroph in vegetable debris, such as leaves and flowers. However, there are also reports that this species is pathogenic in humans, usually occurring in patients with some type of immunosuppression, which predisposes to opportunistic infections. Specimens of P. aphidis were collected from water samples and Rhizophora mangle L. leaves at different salinities along the Perequê River, located in a mangrove swamp area at Parque Estadual da Ilha do Cardoso, Cananéia municipality, São Paulo State, Brazil. Aliquots of these samples were spread in Petri dishes. The samples baited with cataphylls of Allium cepa L. were incubated for seven days at 21 ºC. After incubation, the baits were observed under microscope and the specimens were isolated and purified. The identification of the specimens was made through the phylogenetic analysis of the ITS rDNA region. This is the first record of P. aphidis in São Paulo State.

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Three new basidiomycetous yeasts, Pseudozyma alboarmeniaca sp. nov., Pseudozyma crassa sp. nov. and Pseudozyma siamensis sp. nov. isolated from Thai patients

Cited by 17 publications

References 18 publications

Pseudozyma aphidis fungaemia with invasive fungal pneumonia in a patient with acute myeloid leukaemia: case report and literature review

Pseudozyma aphidis fungaemia with invasive fungal pneumonia in a patient with acute myeloid leukaemia: case report and literature review

First Case of Fungemia Due to Pseudozyma aphidis in a Pediatric Patient with Osteosarcoma in Latin America

Molecular identification of Pseudozyma aphidis (Henninger & Windisch) Boekhout: first record from a Brazilian mangrove swamp

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