Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer's disease: A randomized controlled trial

Silva, Felipe de Oliveira; Ferreira, José Vinícius; Plácido, Jéssica; Sant’Anna, Paula; Araújo, Juliana; Marinho, Valeska; Laks, Jerson; Deslandes, Andréa Camaz

doi:10.1016/j.maturitas.2019.04.217

Cited by 77 publications

(89 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were 16 eligible (Venturelli et al, 2011;Coelho et al, 2012;Vreugdenhill et al, 2012;Andrade et al, 2013;Chang et al, 2015;Holthoff et al, 2015;El-Kader and Al-Jiffr, 2016;Hoffmanna et al, 2016;Ohman et al, 2016;Morris et al, 2017;Pedroso et al, 2017;Rolland et al, 2017;Tootsa et al, 2017;Vidoni et al, 2017;Fonte et al, 2019;Silvaa et al, 2019) RCTs, as shown in Table 1. There were 1,181 participants in total; the smallest sample was 27 participants (Silvaa et al, 2019), and the largest sample was 200 participants (Holthoff et al, 2015). The age of the participants in the experiment ranged from 50 to 96 years old.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…Effect of Physical Activity on Executive Function Issues in AD Patients Twelve articles (Coelho et al, 2012;Vreugdenhill et al, 2012;Andrade et al, 2013;Holthoff et al, 2015;Hoffmanna et al, 2016;Ohman et al, 2016;Morris et al, 2017;Pedroso et al, 2017;Tootsa et al, 2017;Vidoni et al, 2017;Fonte et al, 2019;Silvaa et al, 2019) compared the effects of an intervention group and a control group on executive function before and after the experiment. An asymmetrical funnel plot was presented.…”

Section: Meta-analysis Of Outcome Indicatorsmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis

Zhu

Wang

et al. 2020

Front. Psychol.

View full text Add to dashboard Cite

Objectives: The present study aimed to systematically analyze the effects of physical activity on executive function, working memory, cognitive flexibility, and activities of daily living (ADLs) in Alzheimer's disease (AD) patients and to provide a scientific evidence-based exercise prescription.Methods: Both Chinese and English databases (PubMed, Web of Science, the Cochrane Library, EMBASE, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang) were used as sources of data to search for randomized controlled trials (RCTs) published between January 1980 and December 2019 relating to the effects of physical activity on executive function, working memory, cognitive flexibility, and ADL issues in AD patients. Sixteen eligible RCTs were ultimately included in the meta-analysis.Results: Physical activity had significant benefits on executive function [standard mean difference (SMD) = 0.42, 95% confidence interval (CI) 0.22–0.62, p < 0.05], working memory (SMD = 0.28, 95% CI 0.11–0.45, p < 0.05), cognitive flexibility (SMD = 0.23, 95% CI −0.02 to 0.47, p < 0.01), and ADLs (SMD = 0.68, 95% CI 0.19–1.16, p < 0.05) among AD patients. Subgroup analysis indicated that, for executive function issues, more than 60 min per session for 16 weeks of moderate-to-high-intensity dual-task exercises or multimodal exercise had a greater effect on AD patients. For working memory and cognitive flexibility issues, 60–90 min of moderate-intensity dual-task exercises 1–4 times/week was more effective. For ADL issues, 30–90 min of multimodal exercise at 60–79% of maximal heart rate (MHR) 3–4 times/week had a greater effect on AD patients.Conclusions: Physical activity was found to lead to significant improvements in executive function, working memory, cognitive flexibility, and ADLs in AD patients and can be used as an effective method for clinical exercise intervention in these patients. However, more objective, scientific, and effective RCTs are needed to confirm this conclusion.

show abstract

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

Section: Meta-analysis Of Outcome Indicatorsmentioning

confidence: 99%

Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis

Zhu

Wang

et al. 2020

Front. Psychol.

View full text Add to dashboard Cite

show abstract

“…16 Another study reported similar results, with 12-week multimodal physical exercise program only proven to be effective for MCI patients but not in AD patients. 17 Contradicting results on AD and MCI patients may be due to the differential impact of exercise in the different stages of AD trajectory.…”

Section: Effects Of Moderate Intensity Exercise On the Cortical Thickmentioning

confidence: 99%

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Wang

Kim

et al. 2020

Psychiatry Investig

View full text Add to dashboard Cite

Objective We aimed to explore the impact of moderate intensity exercise on the cortical thickness and subcortical volumes of preclinical Alzheimer’s disease (AD) patients.Methods Sixty-three preclinical AD patients with magnetic resonance imaging (MRI) and 18-florbetaben positron emission tomography (PET) data were enrolled in the study. Information on demographic characteristics, cognitive battery scores, self-reported exercise habits were attained. Structural magnetic resonance images were analyzed and processed using Freesurfer v6.0.Results Compared to Exercise group, Non-Exercise group demonstrated reduced cortical thickness in left parstriangularis, rostral middle frontal, entorhinal, superior frontal, lingual, superior parietal, lateral occipital, inferior parietal gyrus, temporal pole, precuneus, insula, fusiform gyrus, right precuneus, superiorparietal, lateral orbitofrontal, rostral middle frontal, medial orbitofrontal, superior frontal, lingual, middle temporal gyrus, insula, supramarginal, parahippocampal, paracentral gyrus. Volumes of right thalamus, caudate, putamen, pallidum, hippocampus, amygdala were also reduced in Non-Exercise group.Conclusion Moderate intensity exercise affects cortical and subcortical structures in preclinical AD patients. Thus, physical exercise has a potential to be an effective intervention to prevent future cognitive decline in those at high risk of AD.

show abstract

“…Exploring ways of preventing, or delaying the onset this disease is a pragmatic strategy. Regular exercise can reduce the occurrence of AD in the healthy elderly population and delay the progression of MCI, although the bene cial effect is not apparent in the clinical treatment of AD [6][7][8][9][10][11]. The underlying mechanism has not yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological and clinical studies show that physical activity improves cognition during healthy aging [4][5][6], as well as individuals with mild cognitive impairment [7][8][9]. However, exercise therapy has not been shown to exert explicitly bene cial outcomes on patients with AD [10,11]. Exploring the underlying mechanisms for an effective exercise intervention time window is crucial for the prevention of AD.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of voluntary exercise therapy on an Alzheimer’s mouse model are dependent on aquaporin 4-mediated glymphatic transport

Liu

Feng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Epidemiological and clinical evidence suggest there is an effective time window for the ability of exercise to slow the progression of Alzheimer's disease (AD). Astrocyte aquaporin-4 (AQP4) dependent glymphatic transport is necessary for clearance of extracellular amyloid-β (Aβ) from the brain. The purpose of this study is to explore whether this Aβ clearance mechanism is involved in the time-dependent benefit of exercise on Aβ related pathology. Method: 3- and 7-month-old male wild type (WT) mice, APP695swe/PS1-dE9 (APP/PS1) mice and AQP4 knockout (AQP4−/−)/APP/PS1 mice received voluntary wheel exercise intervention for 2 months, followed by behavioral and pathological analyses.Results: 9-month-old APP/PS1 mice showed enhanced reactive astrogliosis, accompanied with widespread loss of perivascular AQP4 polarization, when compared to 5-month-old APP/PS1 mice. Voluntary exercise improved AQP4 polarity and glymphatic transport, reduced glial inflammation and brain Aβ plaque load, plus alleviated synapse protein loss and cognitive deficits in 5-month-old, but not 9-month-old, APP/PS1 mice. Exercise intervention did not mitigate glymphatic transport dysfunction, Aβ accumulation and cognitive impairment in AQP4−/−/APP/PS1 mice at 5 or 9 months of age. Conclusion: These results have revealed that AQP4-dependent glymphatic transport is an influential factor in the timeliness of voluntary exercise ability to alleviate Aβ pathology, potentially offering a new target for the early prevention of the disease.

show abstract

Three months of multimodal training contributes to mobility and executive function in elderly individuals with mild cognitive impairment, but not in those with Alzheimer's disease: A randomized controlled trial

Cited by 77 publications

References 17 publications

Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis

Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Beneficial effects of voluntary exercise therapy on an Alzheimer’s mouse model are dependent on aquaporin 4-mediated glymphatic transport

Contact Info

Product

Resources

About