Three-month, randomized, parallel-group comparison of brimonidine–timolol versus dorzolamide–timolol fixed-combination therapy

Abstract

Fixed-combination brimonidine-timolol provided the same or greater IOP lowering compared with fixed-combination dorzolamide-timolol. Both fixed-combination medications were safe and well-tolerated. Brimonidine-timolol received higher ratings of ocular comfort than dorzolamide-timolol. The duration of the studies was 3 months, and additional studies will be needed to compare the efficacy and tolerability of brimonidine-timolol and dorzolamide-timolol during long-term treatment.

Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma

“…Although most previously published daytime studies 28,29 have demonstrated similar IOP-lowering efficacy for BTFC over DTFC, a recent 3-month parallel-arm study by Nixon et al 38 reported a greater IOP reduction with BTFC monotherapy (À7.7 mm Hg) compared with DTFC monotherapy (À6.7 mm Hg). The study by Nixon et al 38 pooled data from two separate trials: a single site pilot study with 40 patients, and a multi-centre trial with 140 patients.…”

“…Out of the total of 180 patients, 101 were treated with BTFC or DTFC as monotherapy (30 from the pilot study, 71 from the multi-centre trial), whereas 79 patients were treated as an adjunct to prostaglandin therapy. 38 The methodology of that study was critically differed from the protocol utilised in the present study in several ways. First, the Nixon study 38 measured IOP at a single time point (1000) at 2 h post dose.…”

“…38 The methodology of that study was critically differed from the protocol utilised in the present study in several ways. First, the Nixon study 38 measured IOP at a single time point (1000) at 2 h post dose. This time point would be near the peak efficacy for brimonidine, which tends to have a rapid onset of action.…”

“…30 Second, the Nixon study. 38 was a parallel-arm design, whereas the current study had a crossover design. Parallel arm studies tend to require much larger patient numbers to achieve the same statistical power compared with crossover studies.…”

Evaluation of effectiveness of contact transscleral diode laser cyclocoagulation drainage after neovascular glaucoma surgery

“…Возможно и рекомендуется использование комби-нированных медикаментозных средств, однако гипотен-зивный эффект наступает не всегда [15,16]. Проведение лазерных вмешательств на радужке и углу передней ка-меры затруднено из-за выраженного рубеоза (неоваску-ляризации) этих структур [17].…”