Three-month efficacy and safety of once-daily diltiazem in chronic stable angina pectoris

Nadeau, Christine; Hilton, Donald; Savard, Daniel; Morin, Y; Baird, Michael G.; Alexander, Michael; Langer, Galina; Roth, David R.; Boulet, A. P.; Larivière, L.

doi:10.1016/s0002-9149(99)80615-8

The American Journal of Cardiology

1995

DOI: 10.1016/s0002-9149(99)80615-8

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Three-month efficacy and safety of once-daily diltiazem in chronic stable angina pectoris

Christine Nadeau

Donald Hilton

Daniel Savard

et al.

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Cited by 2 publications

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Efficacy and Tolerability of Once-Daily Sustained-Release and Conventional Diltiazem in Patients with Stable Angina Pectoris

Debregeas

Duchier²

1997

Clinical Drug Investigation

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This double-blind dose-response crossover study was designed to compare the efficacy and tolerability of sustained-release (SR) and conventional diltiazem over 4 weeks in patients with stable angina pectoris. Following a 2-week placebo run-in period, 26 patients were randomised into 3 parallel groups to receive either diltiazem SR (180, 240 or 300mg once daily) or conventional diltiazem 60mg three times daily for 2 weeks. Treatments were then crossed over for a further 2-week study period. Antianginal efficacy was evaluated using submaximal treadmill exercise testing. At baseline, all 3 treatment groups were comparable for all parameters. Treatment with both conventional and SR formulations improved exercise time and reduced intensity of ischaemia, but the difference between groups at the end of each 2-week treatment phase was not statistically significant. The results did not suggest a dose-response relationship. Adverse reactions necessitated treatment discontinuation in two patients being treated with conventional diltiazem and in one patient receiving diltiazem SR 240mg. In conclusion, this study demonstrated that diltiazem SR 180, 240 and 300mg did not differ from the conventional formulation in terms of anti-ischaemic efficacy.

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Efficacy and Tolerability of Once-Daily Sustained-Release and Conventional Diltiazem in Patients with Stable Angina Pectoris

Debregeas

Duchier²

1997

Clinical Drug Investigation

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The role of calcium antagonists in the treatment of cardiovascular disease: Focus on diltiazem

2015

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The article deals with the use of calcium antagonists (CA) with a focus on diltiazem for the treatment of hypertension, angina pectoris, and cardiac arrhythmias, for secondary prevention of coronary heart disease, to evaluate their cardiac, angiography, nephroprotective effect, the ability to prevent the development of left ventricular hypertrophy. The problems of tolerability and safety of CA in short and prolonged action.

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Three-month efficacy and safety of once-daily diltiazem in chronic stable angina pectoris

Cited by 2 publications

References 23 publications

Efficacy and Tolerability of Once-Daily Sustained-Release and Conventional Diltiazem in Patients with Stable Angina Pectoris

Efficacy and Tolerability of Once-Daily Sustained-Release and Conventional Diltiazem in Patients with Stable Angina Pectoris

The role of calcium antagonists in the treatment of cardiovascular disease: Focus on diltiazem

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