“…13 Accepted: 2020-05 -29 2020SciPress Ltd, Switzerland Online: 2020 H. squarrosa is known as a highly valuable medicinal plant, which contains alkaloids, flavones, triterpenes, phenolic acids, especially including Huperzine A (Hup A), Huperzine B (Hup B), N-methyl-huperzine B, Huperzinine, Lycoporine A, Carina-tumine A, etc [5]. To the best of our knowledge, over 300 Lycopodium alkaloids have been reported [6]. According to the report of Ngoc et al [7], the alkaloids isolated from H. squarrosa collected from Lam Dong province -Vietnam includes 6 main compounds: lycosquarosine A, acetylaposerratinine, huperzine A, huperzine B, 8α-hydrophlemariurine B and huperzinine which may account for the effectiveness of this plant in the treatment of several brain diseases [8].…”