Three hour abstinence as a treatment for high sperm DNA fragmentation: a prospective cohort study

Dahan, Michael H.; Mills, Ginevra; Khoudja, Rabea Youcef; Gagnon, Abbie; Tan, Guan Huat; Tan, Seang Lin

doi:10.1007/s10815-020-01999-w

Cited by 22 publications

(26 citation statements)

References 27 publications

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“…33,34 Studies have also recommended a short or ultrashort time gap between two ejaculations, especially in patients with high levels of SDF. 23,35,36 However, it is important to note that spermatozoa collected following a short LEA tend to have immature chromatin, which could affect DNA longevity. 11,24 Although the abnormal cohort in this study had an increased number of DNA-fragmented spermatozoa in relation to LEA, a significant difference was found specifically between the 0-2-day and 3-5-day LEA groups.…”

Section: Discussionmentioning

confidence: 99%

“…Despite low ejaculate volume, short LEA yielded spermatozoa with better functional ability 33,34 . Studies have also recommended a short or ultrashort time gap between two ejaculations, especially in patients with high levels of SDF 23,35,36 . However, it is important to note that spermatozoa collected following a short LEA tend to have immature chromatin, which could affect DNA longevity 11,24 .…”

Section: Discussionmentioning

confidence: 99%

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Sperm characteristics in normal and abnormal ejaculates are differently influenced by the length of ejaculatory abstinence

et al. 2022

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Background:No association between the length of ejaculatory abstinence (LEA) and semen characteristics has been confirmed. A short LEA has been linked to improved sperm characteristics and a higher pregnancy rate, but its negative influence on sperm chromatin maturity and longevity may adversely affect reproductive outcomes. Objectives:We sought to determine the influence of LEA on (i) semen parameters in normozoospermic and abnormal ejaculates; and (ii) the outcomes of spermpreparation methods in a large number of subfertile men undergoing infertility workups. Materials and methods:This retrospective registry-based cohort study analyzed the data of 10,674 ejaculates from 7972 subfertile men, who were then segregated into normozoospermic, oligozoospermic, asthenozoospermic, and oligoasthenozoospermic cohorts. Variations in semen characteristics and post-wash outcomes were studied between four LEA intervals across 0-15 days.Results: An age-adjusted analysis of covariance (ANCOVA) model linked significant increases in ejaculate volume, sperm concentration (except in the oligozoospermic cohort), and total sperm count to an increased LEA (p < 0.05). LEA was negatively associated with motility (except in the asthenozoospermic cohort) and vitality (p < 0.05).Large-headed spermatozoa were less common with an increased LEA only in the oligoasthenozoospermic cohort (p < 0.05). In the normozoospermic cohort, a longer LEA led to fewer spermatozoa with amorphous heads but more spermatozoa with tapered heads and cytoplasmic droplets (p < 0.05). LEA extension resulted in greater sperm DNA fragmentation in the abnormal cohort (p < 0.01). The post-wash sperm concentration and total motile sperm count were significantly improved with a longer LEA in the normozoospermic cohort (p < 0.05). Discussion and conclusion:Considering the findings in this study and existing literature, a generalized recommendation for long LEA has no clinical value. The LEA should be individualized based on the ejaculate profile and the need for specific clinical intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sperm characteristics in normal and abnormal ejaculates are differently influenced by the length of ejaculatory abstinence

et al. 2022

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“…Prolonged sexual abstinence may lead to the accumulation of reactive oxygen species and further aggravated oxidative stress injury of spermatozoa 21 , 23 . It might be worth increasing ejaculations in order to improve sperm parameters, SDF, and consequently pregnancy outcome 24 – 26 .Regular intercourse at least twice a week was recommended for couples trying to conceive 27 . It was more common for male partners with ED to engage in “timed intercourse” 28 , sexual activity during the ovulation period to increase conception chances.…”

Section: Discussionmentioning

confidence: 99%

Sexual dysfunction is more common among men who have high sperm DNA fragmentation or teratozoopermia

Zhang

Wang

2022

Sci Rep

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Men in couples that have experienced pregnancy loss have a higher risk of sexual dysfunction. Semen quality impairment is common in men of couples with pregnancy loss. The objective of this article is to evaluate the differences in the incidence of male sexual dysfunction in a cohort of pregnancy loss couples with different types of semen quality impairment. A cross-sectional analysis of 426 men who attended our outpatient clinic for couples’ pregnancy loss, those without genetic abnormalities were included in the final analysis covering June 2021 to October 2021. The patients were divided into 5 groups according to type of semen quality impairment: normozoospermia group (group normal; N = 161), high sperm DNA fragmentation group (group high-SDF; N = 87), isolated asthenozoospermia group (group iAstheno; N = 45), isolated teratozoopermia group (group iTerato; N = 44), and ≥ 2 abnormal sperm parameters group (group multiple; N = 89). All subjects underwent a complete physical inspection, including palpation of the male genitalia and semen analysis. Validated assessment tools for erectile dysfunction (the International Index of Erectile Function -IIEF-5) and anxiety (the seven-item Generalized Anxiety Disorder Scale- GAD-7) were also used. Men with high sperm DNA fragmentation and isolated teratozoopermia were associated with increased erectile dysfunction risk when compared with normozoospermic men, with an OR of 2.75 [1.49–5.09; p = 0.001] and 2.44 [1.22–5.31; p = 0.024], respectively. It is interesting to note that there was no difference in prevalence of erectile dysfunction between Group iAstheno and Group normal (20.0% vs. 18.0%; OR = 1.24 [0.52–2.97]; P = 0.625). More than half (50.6%) of the participants in Group high-SDF reported sexual intercourse less than once per week, much more than those in the normozoospermia group (23.2%, p < 0.05), followed by Group iTerato (44.4%) and Group multiple (46.1%). GAD-7 scores increased slightly but significantly among groups when compared with Group normal. Not surprisingly, GAD-7 scores remained higher in Group high-SDF. In males of pregnancy loss couples, men with high sperm DNA fragmentation and teratozoopermia suffer from a higher incidence of erectile dysfunction. This phenomenon is not significant in men with isolated asthenozoospermia. Proper counseling and treatment of impaired semen quality are warranted.

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“…It has been shown that although longer ejaculatory abstinence promotes sperm DNA damage, 12,15 it is associated with increased sperm volume, motility, and count 12,15,17 . On the other hand, some studies documented that shorter ejaculatory abstinence, about 4–24 h, is associated with better sperm quality using conventional semen analysis than a longer abstinence period 14,17,18,20 . Interestingly, some recent studies revealed that abstinence length is only arbitrary and does not influence semen quality 13,19 .…”

Section: Introductionmentioning

confidence: 99%

“…12,15,17 On the other hand, some studies documented that shorter ejaculatory abstinence, about 4-24 h, is associated with better sperm quality using conventional semen analysis than a longer abstinence period. 14,17,18,20 Interestingly, some recent studies revealed that abstinence length is only arbitrary and does not influence semen quality. 13,19 Hence, standardizing the recommended ejaculatory abstinence period remains pertinent for male infertility evaluation, and a successful spontaneous and assisted conception.…”

Section: Introductionmentioning

confidence: 99%

Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

Akhigbe

Hamed

Dutta

et al. 2022

Health Science Reports

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Background and Aims: Several studies have shown that the length of ejaculatory abstinence alters sperm quality. However, the available data are conflicting and none seems to exist in a Nigerian population. The present study aims to compare the semen quality in normozoospermic and oligozoospermic semen samples of a homogenous Nigerian population, following varying ejaculatory abstinence days (EAD); less than 2, 2-3, and 3-7 days.Methods: The present retrospective study included 5165 semen samples collected over 5 years, from April 2015 to April 2020.Results: In normozoospermic samples, sperm count and total sperm count were significantly higher in prolonged EAD. In oligozoospermic patients, semen volume significantly increased with prolonged EAD, while sperm count, total sperm count, and progressive motility were significantly reduced with prolonged EAD. In addition, EAD and sperm volume positively correlated in oligozoospermic patients. Conclusion:Our findings indicate that EAD affects sperm quality in both normozoospermic and oligozoospermic men with varying impacts. Prolonged EAD increased sperm count and total sperm count in normozoospermic patients, while EAD increased semen volume but reduced sperm count, total sperm count, and progressive motility in oligozoospermic patients.

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Three hour abstinence as a treatment for high sperm DNA fragmentation: a prospective cohort study

Cited by 22 publications

References 27 publications

Sperm characteristics in normal and abnormal ejaculates are differently influenced by the length of ejaculatory abstinence

Sperm characteristics in normal and abnormal ejaculates are differently influenced by the length of ejaculatory abstinence

Sexual dysfunction is more common among men who have high sperm DNA fragmentation or teratozoopermia

Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

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