Three examples of anti-Fy3 produced in negroes

Duffy blood group phenotype–genotype correlations using high‐resolution melting analysis PCR and microarray reveal complex cases including a new null FY*A allele: the role for sequencing in genotyping algorithms

“…This arises from homozygosity for FY*B allele carrying a c.1-67T>C in the GATA-1 box promoter region (FY*02N.01) preventing Fy b expression on red blood cells (RBC) [14,18]. However, the Duffy antigens are expressed in non-erythroid tissues, and Africans with the Fy(a-b-) phenotype rarely make anti-Fy b or anti-Fy3 [2, [19][20][21][22][23][24].…”

Acute hemolytic transfusion reaction secondary to anti-Fy3

“…Since that initial report, several other examples of anti-Fy3 have been described. [16][17][18][19][20][21][22] This is a clinically significant antibody associated with mild HDN in two offspring of the initially reported subjects. 15,16 Additional cases of this antibody developing after transfusion have been cited.…”

“…African American patients who developed anti-Fy3, with or without signs and symptoms of hemolysis, usually had concomitant alloantibodies within the Duffy system, especially anti-Fy a . 19,20,23 We are describing a patient who developed an intravascular hemolysis due to anti-Fy3, in the absence of any other alloantibody. This patient had a history of RBC transfusion.…”

“…Interestingly, African American individuals whose RBCs phenotype as Fy(a-b-) usually develop anti-Fy3 after making anti-Fy a or other alloantibodies. [19][20][21][22] We report a case of an African American patient without sickle cell disease in whom solely anti-Fy3 was shown to cause a severe hemolytic transfusion reaction.…”

Severe delayed hemolytic transfusion reaction due to anti-Fy3 in a patient with sickle cell disease undergoing red cell exchange prior to hematopoietic progenitor cell collection for gene therapy

“…Fy b is expressed on other tissues. These patients remain at risk for anti-Fy3, which can be clinically significant, and patients with an existing anti-Fy a are at increased risk (9,13). The reasons for this have long been studied but are yet to be determined.…”