Three Distinct Blue-Green Color Pathways in a Mammalian Retina

Mills, Steven; Tian, Lian-Ming; Hoshi, Hideo; Whitaker, Christopher J.; Massey, Stephen C.

doi:10.1523/jneurosci.3901-13.2014

Cited by 37 publications

(47 citation statements)

References 34 publications

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“…4-6) was not predicted from BCs, which instead displayed an approximately balanced mix of blue-On and -Off circuits (Zimmermann et al, 2018). The near-complete absence of blue-On signals in zebrafish RGCs is also in stark contrast to the importance of multiple blue-On RGC circuits in mammals (Marshak and Mills, 2014;Mills et al, 2014) including in primates (Calkins et al, 1998;Dacey, 1996;Dacey and Lee, 1994). Next, while many of the dominant spectral opponencies observed in RGCs (Fig.…”

Section: Figure 11 | Putative 'Prey-capture-rgcs' Revealed Following mentioning

confidence: 92%

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

Zhou

Bear

Roberts

et al. 2020

Preprint

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In vertebrate vision, the tetrachromatic larval zebrafish permits non-invasive monitoring and manipulating of neural activity across the nervous system in vivo during ongoing behaviour. However, despite a perhaps unparalleled understanding of links between zebrafish brain circuits and visual behaviours, comparatively little is known about what their eyes send to the brain in the first place via retinal ganglion cells (RGCs). Major gaps in knowledge include any information on spectral coding, and information on potentially critical variations in RGC properties across the retinal surface to acknowledge asymmetries in the statistics of natural visual space and behavioural demands.Here, we use in vivo two photon (2P) imaging during hyperspectral visual stimulation as well as photolabeling of RGCs to provide the first eye-wide functional and anatomical census of RGCs in larval zebrafish.We find that RGCs' functional and structural properties differ across the eye and include a notable population of UV-responsive On-sustained RGCs that are only found in the acute zone, likely to support visual prey capture of UV-bright zooplankton. Next, approximately half of RGCs display diverse forms of colour opponency -long in excess of what would be required to satisfy traditional models of colour vision. However, most information on spectral contrast was intermixed with temporal information. To consolidate this series of unexpected findings, we propose that zebrafish may use a novel "dual-achromatic" strategy segregated by a spectrally intermediate background subtraction system. Specifically, our data is consistent with a model where traditional achromatic image-forming vision is mainly driven by longwavelength sensitive circuits, while in parallel UV-sensitive circuits serve a second achromatic system of foreground-vision that serves prey capture and, potentially, predator evasion.

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Section: Figure 11 | Putative 'Prey-capture-rgcs' Revealed Following mentioning

confidence: 92%

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

Zhou

Bear

Roberts

et al. 2020

Preprint

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“…This is consistent with the presence of two classes of cones in the rabbit retina from which signals are compared in an opponent fashion. Indeed, the rabbit retina contains RGCs with S-ON center and M-OFF surrounds (Caldwell and Daw, 1978), as well as two types of RGCs with an S-OFF center and M-ON surround differing in their stratification (Mills et al, 2014; Vaney et al, 1981), providing a retinal mechanism for the sensitivity to blue/yellow decrements.…”

Section: Chromatic Circadian Photosensitivity In Mammalsmentioning

confidence: 99%

Chromatic clocks: Color opponency in non-image-forming visual function

Spitschan

Lucas

Brown

2017

Neuroscience & Biobehavioral Reviews

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During dusk and dawn, the ambient illumination undergoes drastic changes in irradiance (or intensity) and spectrum (or color). While the former is a well-studied factor in synchronizing behavior and physiology to the earth’s 24-h rotation, color sensitivity in the regulation of circadian rhythms has not been systematically studied. Drawing on the concept of color opponency, a well-known property of image-forming vision in many vertebrates (including humans), we consider how the spectral shifts during twilight are encoded by a color-opponent sensory system for non-image-forming (NIF) visual functions, including phase shifting and melatonin suppression. We review electrophysiological evidence for color sensitivity in the pineal/parietal organs of fish, amphibians and reptiles, color coding in neurons in the circadian pacemaker in mice as well as sporadic evidence for color sensitivity in NIF visual functions in birds and mammals. Together, these studies suggest that color opponency may be an important modulator of light-driven physiological and behavioral responses.

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“…Thus, the ON response is inverted to an OFF response and its color-opponent nature is preserved (Chen & Li 2012, Sher & DeVries 2012). The above mechanisms for conveying S-cone signals to ganglion cells are apparently complemented by OFF-type S-cone bipolar cells in some species (Klug et al 2003, Yin et al 2009, Mills et al 2014). …”

Section: Lateral Inhibition Modifies Signaling By Vertical Excitatorymentioning

confidence: 99%

Functional Circuitry of the Retina

Demb

Singer

2015

Annu. Rev. Vis. Sci.

158

131

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The mammalian retina is an important model system for studying neural circuitry: Its role in sensation is clear, its cell types are relatively well defined, and its responses to natural stimuli—light patterns—can be studied in vitro. To solve the retina, we need to understand how the circuits pre-synaptic to its output neurons, ganglion cells, divide the visual scene into parallel representations to be assembled and interpreted by the brain. This requires identifying the component interneurons and understanding how their intrinsic properties and synapses generate circuit behaviors. Because the cellular composition and fundamental properties of the retina are shared across species, basic mechanisms studied in the genetically modifiable mouse retina apply to primate vision. We propose that the apparent complexity of retinal computation derives from a straightforward mechanism—a dynamic balance of synaptic excitation and inhibition regulated by use-dependent synaptic depression—applied differentially to the parallel pathways that feed ganglion cells.

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Three Distinct Blue-Green Color Pathways in a Mammalian Retina

Cited by 37 publications

References 34 publications

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

Chromatic clocks: Color opponency in non-image-forming visual function

Functional Circuitry of the Retina

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