Three‐dimensional volumetric quantification of fat loss following cryolipolysis

Abstract

Background and Objectives Cryolipolysis is a noninvasive and well-tolerated treatment for reduction of localized subcutaneous fat. Although several studies demonstrate the safety and efficacy of this procedure, volumetric fat reduction from this treatment has not been quantified. This prospective study investigated the change in volume of fat after cryolipolysis treatment using three-dimensional (3D) photography. Materials and Methods A prospective study of subjects treated with cryolipolysis on the flank (love handle) was performed at Massachusetts General Hospital. Volume measurements were performed with a Canfield Scientific Vectra three-dimensional camera and software to evaluate the amount of post procedure volume change. Clinical outcomes were assessed with caliper measurements, subject surveys, and blinded physician assessment of photographs. Results Eleven subjects were enrolled in this study. Each subject underwent a single cycle of cryolipolysis to one flank. The untreated flank served as an internal control. The follow up time after treatment was two months. The mean amount of calculated absolute fat volume loss using 3D photography from baseline to 2 months follow up visit was 56.2 ± 25.6 from the treatment site and 16.6 ± 17.6 cc from the control (p < 0.0001). A mean absolute difference of 39.6 cc between the treated and untreated sides was calculated at 2 months post-treatment. Comparison of caliper measurements from baseline to 2 months post-treatment demonstrated significant reduction of the treated flank from 45.6 ± 5.8 mm at baseline to 38.6 ±4.6 mm at 2 months post-treatment (p<0.001). The untreated flank did not show significant reduction with caliper measurements demonstrating 45.3 ± 5.0 mm at baseline and 44.6 ± 5.1 mm at 2 months post-treatment (p=0.360). No unexpected side effects or adverse events were reported. Post-treatment satisfaction surveys demonstrated 82% of subjects were satisfied with the results. Conclusions Cryolipolysis is a safe, well-tolerated and effective noninvasive fat removal methodology that on average leads to 39.6 cc of fat loss at 2 months after a single treatment cycle.

Cryolipolysis and Skin Tightening

“…There has been 1 study to date looking at volumetric changes with cryolipolysis. 17 In this study, 1 flank (randomized) was treated so that the partner side could serve as an internal control. The mean volume loss in the treated flank at 2 months after treatment was 56.2 6 25.6 mL versus 16.6 6 17.6 mL in the untreated flank (p < .0001).…”

Multiple same day cryolipolysis treatments for the reduction of subcutaneous fat are safe and do not affect serum lipid levels or liver function tests

“…Treatment of one flank leads to the loss of about 40 g of fat over 3 months 10. Thus, treating the abdomen and bilateral flanks will cause about 160 g of fat to be lost during this same time period.…”

Noninvasive Body Contouring: Literature Review and Summary of Objective Data

“…Only one treatment was usually necessary but diminishing returns with additional treatments were reported 18 and onset took about 8 weeks 11,44 . In addition to the abdomen 10,18,[45][46] , flank 10-11, 18, 44-48 , buttocks 45 and back 10,[45][46] , specific applicators exist for the arms 50 , knees 10,45 and thighs 10,[45][46][49][50][51][52] .…”