Three‐Dimensional Transvaginal Sonography and Magnetic Resonance Imaging for Local Staging of Cervical Cancer

Arribas, Sara; Alcázar, Juan Luis; Sarasa, María A. Martínez; Benito, Alberto; Mínguez, J.; Jurado, M.

doi:10.7863/ultra.15.05071

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…Recently, a study has been published on the correlation between the accuracy of 2D and 3D US and MRI on parametrial infiltration, showing a high correlation (79%), similar to our own results (84%) [15]. In another recent study, 3D sonography showed good agreement with MRI for assessing parametrial infiltration and bladder involvement [16]. These studies could not use histology as the gold standard to evaluate the real parametrial infiltration.…”

Section: Discussionsupporting

confidence: 85%

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound

et al. 2020

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Objectives: To analyze the diagnostic accuracy of two-dimensional (2D) and three-dimensional transvaginal ultrasound (3D TV-US) for evaluation of parametrial status in locally advanced cervical cancer patients after neoadjuvant chemotherapy (NACT), using histology as the gold standard. Methods: Consecutive patients with histologically confirmed cervical cancer were staged according to FIGO (International Federation of Gynaecology and Obstetrics) criteria. All IB2-IIIB FIGO stage patients were examined by 2D and 3D TV-US and magnetic resonance imaging (MRI) at the diagnosis time (T0) and after NACT. At T0, the US evaluation of parametrial involvement was compared to MRI before treatment. The results of US and MRI examinations of parametrial status after NACT were compared with the histological specimen. Results: We enroled 51 consecutive patients in the study. Before chemotherapy, clinical examination under anaesthesia identified parametrial involvement in 48 patients, ultrasonography in 46 patients, and MRI in 49 patients. The agreement between US and MRI was 94%. The sensitivity of US for parametrial status was 93.8%, with a positive predictive value of 97.8%, using MRI as the standard. The correlation between US and MRI was statistically significant (p = 0). After chemotherapy, histological examination of surgical specimens identified parametrial involvement in 3 patients. Ultrasonography correctly identified those cases with parametrial infiltration, recording a sensitivity of 100%, specificity of 90.9%, positive predictive value of 50%, and negative predictive value of 100%. The MRI had a sensitivity of 100%, specificity of 45.5%, positive predictive value of 14.3%, and negative predictive value of 100%, respectively. The concordance in the identification of the presence/absence of infiltration between US and MRI with histology was 90% (p = 0.001) and 61%, respectively, after chemotherapy treatment. Particularly, in defining the degree of infiltration, the agreement between US and MRI with histology was 90 and 58%, respec

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Section: Discussionsupporting

confidence: 85%

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound

et al. 2020

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“…31Y34 However, 2D TVUS and 3D TVUS were also shown to have good correlation with MRI in size estimation for cervical cancer. 35,36 The agreement between TVUS and pathological examination with regard to tumor size was also shown to be highly correlated, with a coefficient value of 0.92. 37 In a recent European multicenter trial along with high accurate preoperative assessment, it was emphasized that ultrasonography may be more accurate than MRI in detecting residual tumors and assessing parametrial invasion.…”

Section: Discussionmentioning

confidence: 80%

Preoperatively Assessable Clinical and Pathological Risk Factors for Parametrial Involvement in Surgically Treated FIGO Stage IB–IIA Cervical Cancer

Canaz

Özyürek

Erdem

et al. 2017

International Journal of Gynecological Cancer

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Endophytic clinical presentation and larger clinical tumor size (>3 cm) are independent risk factors for PMI in stage IB-IIA cervical cancer. Approximately 78% of the patients with a tumor size of more than 3 cm and endophytic presentation will require adjuvant chemoradiation for PMI following radical surgery. Considering clinical tumor presentation along with tumor size can enhance the physician's prediction of PMI in early-stage cervical cancer.

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“…Some, comparing sonographic and MRI evaluation in assessing the presence and extent of disease, included both patients with early‐stage disease undergoing primary surgery and those with locally advanced cervical cancer undergoing neoadjuvant treatment. In all previous studies, the ultrasound scan was performed only before or only after treatment. In contrast, in the present study we analyzed ultrasound parameters only in patients undergoing neoadjuvant chemoradiation and we performed the examinations before, after and during treatment.…”

Section: Discussionmentioning

confidence: 99%

PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery

Testa

Ferrandina

Moro

et al. 2018

Ultrasound in Obstet & Gyne

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Ultrasound and contrast parameters differ between LACC patients with complete response and those with partial response before and after 2 weeks of neoadjuvant treatment. However, neither ultrasound parameters before treatment nor those after 2 weeks of treatment had cut-off values with acceptable sensitivity and specificity for predicting partial pathological response to neoadjuvant therapy. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

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Three‐Dimensional Transvaginal Sonography and Magnetic Resonance Imaging for Local Staging of Cervical Cancer

Abstract: Three-dimensional sonography showed good agreement with MRI for assessing parametrial infiltration and bladder involvement in cervical cancer.

Cited by 14 publications

References 23 publications

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound

Evaluation of Parametrial Status in Locally Advanced Cervical Cancer Patients after Neoadjuvant Chemotherapy: A Prospective Study on Diagnostic Accuracy of Three-Dimensional Transvaginal Ultrasound

Preoperatively Assessable Clinical and Pathological Risk Factors for Parametrial Involvement in Surgically Treated FIGO Stage IB–IIA Cervical Cancer

PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery

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