Abstract. This paper presents a new biomimetic approach to the structural design. For the purpose of aircraft wing design the numerical environment combining simultaneous structural size, shape, and topology optimization based on aeroelastic analysis was developed. For the design of aircraft elements the optimization process must be treated as a multi-load case task, because during the fluid structure interaction analysis each step represents a different structural load case. Also, considering different angles of attack, during the CFD computation each result is considered. The method-specific features (such as domain independence, functional configurations during the process of optimization, and multiple load case solution implemented in the optimization scenario) enable the optimal structural form. To illustrate the algorithm functionality, the problem of determining the optimal internal wing structure was presented. The optimal internal wing structure resulting from aeroelastic computation with different angles of attack has been presented. ture of a wing. Their solution computed the pressure distribution for an analyzed shape, but missed coupling. Another approach to wing optimization refers to the reduction of skin thickness, which was done by Wang and Williams [3]. The wing was divided into dozens of panels, modeled as membranes. The wing՚s weight was reduced along with the increased stiffness of the whole model, stemming from the modification of the membranes thickness.In the papers of Krog [4, 5] the optimization of Airbus A380 ribs was treated as a two-step process. Potential geometry was reduced using standard topology optimization, and then the geometrical model was created for structural optimization purposes. Finally, the optimal structure was transformed into a CAD model which was afterwards verified.Stettner and Schuhmacher [6] also referred to topological and structural optimizations for designing the rear part of a military transport aircraft fuselage. The whole assembly as well as its frame has been analyzed with the same optimization methods within a two-stage process. The results were obtained separately for bending load, torsional load, and pressure exerted on side walls. Additionally, authors attempted to compile the individual results into a single form. However, it has to be emphasized that presented solution did not result from multi-load case calculations.Maute and Allen [7] suggested implementation of structural optimization methods in combination with an aeroelastic simulation. The problem was presented on the example of a slim wing model used for the two-dimensional topological optimization. The obtained configuration presented a conceptual distribution of the material inside the wing subjected to the impact of surrounding flow. The internal structure significantly differed from one we might expect on the basis of an analysis of the regular pressure distribution over a wing surface.