Three-dimensional stereotactic ROI template for measuring regional cerebral blood flow in 99mTc-ECD SPECT: comparison with the manual tracing method

Nagasawa, Naoki; Yamakado, Koichiro; Yamada, Tomomi; Nakanishi, Satoshi; Ito, Morihiro; Suzawa, Naohisa; Kitano, Tokio; Takeda, Kan

doi:10.1097/mnm.0b013e328314b8a8

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…We adopted fully automated ROI analysis software developed by Takeuchi et al, named three‐dimensional stereotactic ROI template (3DSRT) (Takeuchi et al, 2003, 2004, 2006). This software is available free on Windows at any facility and is used by many clinicians to investigate rCBF quantitatively for adults and children (Ito et al, 2005; Kobayashi et al, 2008; Tateno et al, 2008; Kimura et al, 2009; Nagasawa et al, 2009). The SPECT images were anatomically standardized using statistical parametric mapping 99 followed by quantification of 318 ROIs unilaterally, grouped into 12 segments: callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampus, and cerebellum (Fig.…”

Section: Methodsmentioning

confidence: 99%

Interictal cerebral blood flow abnormality in cryptogenic West syndrome

Hamano¹,

Higurashi²,

Koichihara³

et al. 2010

Epilepsia

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SUMMARYPurpose: To elucidate the abnormality of interictal regional cerebral blood flow (rCBF) of West syndrome at the onset. Methods: Quantitative measurement of rCBF with an autoradiography method using N-isopropyl-( 123 I) p-iodoamphetamine single photon emission computed tomography (SPECT) was performed on 14 infants with cryptogenic West syndrome. Regions of interest (ROIs) for rCBF were placed automatically using an automated ROI analysis software (three-dimensional stereotactic ROI template), and were grouped into 12 segments: callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nucleus, thalamus, hippocampus, and cerebellum. We compared rCBF between the patients and seven age-matched infants with cryptogenic focal epilepsy as a control group. The patients were divided into two groups according to the duration from onset to SPECT, to compare rCBF. Results: Quantitative analysis revealed cerebral hypoperfusion in cryptogenic West syndrome with normal SPECT images under visual inspection. In bilateral central, posterior cerebral, pericallosal, lenticular nucleus, and hippocampus, and in the left parietal, temporal, and cerebellum, and in the right angular and thalamus segments there were statistical differences (p < 0.05). Compared with the duration from onset to SPECT, there were no significant differences of rCBF in all segments. Discussion: Broad cerebral hypoperfusion with posterior predominance involving the hippocampus and lenticular nucleus implies that even cryptogenic West syndrome has a widespread cerebral dysfunction at least transiently, which would correspond to clinical manifestations of hypsarrhythmia and epileptic spasms. Hippocampal hypoperfusion suggests the dysfunction of hippocampal circuitry in the brain adrenal axis, and may contribute to subsequent cognitive impairment of cryptogenic West syndrome.

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