Three-dimensional stereotactic atlas of the adult human skull correlated with the brain, cranial nerves, and intracranial vasculature

Nowinski, Wiesław L.; Thaung, Thant Shoon Let; Chua, Beng Choon; Su, Yi; Ngai, Vincent; Yang, Yili; Chrzan, Robert; Urbanik, Andrzej

doi:10.1016/j.jneumeth.2015.02.012

Cited by 17 publications

(12 citation statements)

References 11 publications

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“…The Human Brain Project was another large-scale U.S. federally funded structural database initiative directed at integrated neuroanatomical imaging and brain-mapping, and along with a number of other institutions, the University of Washington Digital Anatomist Project also participated in its various objective programs (Toga and Thompson, 2001;Brinkley and Rosse, 2002). Early products included interactive brain atlases (Brinkley and Rosse, 2002), and later work by Nowinski and colleagues (Nowinski, 2008;Nowinski et al, 1997Nowinski et al, , 2009Nowinski et al, , 2012aNowinski et al, , 2012bNowinski and Chua 2013;Nowinski et al, 2015) greatly advanced the objectives of functionally integrating imaging-based stereotaxic-precision atlases into clinically useful tools for neuroradiology and neurosurgery.…”

Section: The Visible Human Project and Internet-based Human Structuramentioning

confidence: 99%

From chalkboard, slides, and paper to e‐learning: How computing technologies have transformed anatomical sciences education

Trelease

2016

Anatomical Sciences Ed

192

163

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Until the late-twentieth century, primary anatomical sciences education was relatively unenhanced by advanced technology and dependent on the mainstays of printed textbooks, chalkboard- and photographic projection-based classroom lectures, and cadaver dissection laboratories. But over the past three decades, diffusion of innovations in computer technology transformed the practices of anatomical education and research, along with other aspects of work and daily life. Increasing adoption of first-generation personal computers (PCs) in the 1980s paved the way for the first practical educational applications, and visionary anatomists foresaw the usefulness of computers for teaching. While early computers lacked high-resolution graphics capabilities and interactive user interfaces, applications with video discs demonstrated the practicality of programming digital multimedia linking descriptive text with anatomical imaging. Desktop publishing established that computers could be used for producing enhanced lecture notes, and commercial presentation software made it possible to give lectures using anatomical and medical imaging, as well as animations. Concurrently, computer processing supported the deployment of medical imaging modalities, including computed tomography, magnetic resonance imaging, and ultrasound, that were subsequently integrated into anatomy instruction. Following its public birth in the mid-1990s, the World Wide Web became the ubiquitous multimedia networking technology underlying the conduct of contemporary education and research. Digital video, structural simulations, and mobile devices have been more recently applied to education. Progressive implementation of computer-based learning methods interacted with waves of ongoing curricular change, and such technologies have been deemed crucial for continuing medical education reforms, providing new challenges and opportunities for anatomical sciences educators. Anat Sci Educ 9: 583-602. © 2016 American Association of Anatomists.

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Section: The Visible Human Project and Internet-based Human Structuramentioning

confidence: 99%

From chalkboard, slides, and paper to e‐learning: How computing technologies have transformed anatomical sciences education

Trelease

2016

Anatomical Sciences Ed

192

163

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“…Then, the deformation field calculated for the structural scan of the brain specimen shall be applied to the corresponding 3D cerebral model. We have designed the atlases to run on a standard computer and mobile platforms (including iPad [ 34 ] and Android-based [ 35 ]) in order to make them affordable to a wide spectrum of users ranging from a layman to researcher to medical student to clinician. By extending the model to the head and neck, the applicability of the atlas is expanded.…”

Section: Discussionmentioning

confidence: 99%

“…Our endeavor shifts the brain atlas development paradigm FROM fragmented studies and mosaic content, “copy and paste” neuroanatomy, static presentation, and tedious neurological description TO holistic representation, truly 3D structural, vascular, connectional and functional neuroanatomy, dynamic brain de/composition (from blocks to brain), dysfunction brain atlases, and brain at work. Several atlases have been created within this family (an atlas of cerebral vasculature [ 29 ] as well as the human brain in 1492 [ 30 , 31 ] (two editions), 1969 [ 32 , 33 ] (2 editions) along with mobile versions on iPad [ 34 ] and Android-based [ 35 ], and 2953 [ 36 ] pieces along with the 3D atlas of neurologic disorder (on desktop [ 37 ] and iPad [ 38 ])), and they excellently illustrate our strategy and paradigm shift.…”

Section: Methodsmentioning

confidence: 99%

Toward the holistic, reference, and extendable atlas of the human brain, head, and neck

Nowinski

2015

Brain Inf.

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Despite numerous efforts, a fairly complete (holistic) anatomical model of the whole, normal, adult human brain, which is required as the reference in brain studies and clinical applications, has not yet been constructed. Our ultimate objective is to build this kind of atlas from advanced in vivo imaging. This work presents the taxonomy of our currently developed brain atlases and addresses the design, content, functionality, and current results in the holistic atlas development as well as atlas usefulness and future directions. We have developed to date 35 commercial brain atlases (along with numerous research prototypes), licensed to 63 companies and institutions, and made available to medical societies, organizations, medical schools, and individuals. These atlases have been applied in education, research, and clinical applications. Hundreds of thousands of patients have been treated by using our atlases. Based on this experience, the first version of the holistic and reference atlas of the brain, head, and neck has been developed and made available. The atlas has been created from multispectral 3 and 7 Tesla and high-resolution CT in vivo scans. It is fully 3D, scalable, interactive, and highly detailed with about 3,000 labeled components. This atlas forms a foundation for the development of a multi-level molecular, cellular, anatomical, physiological, and behavioral brain atlas platform.Electronic supplementary materialThe online version of this article (doi:10.1007/s40708-015-0012-4) contains supplementary material, which is available to authorized users.

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“…In addition, we use the Allen brain atlas to rule out the possibility that mice brain structures could be affected by Hamilton introduction (Fig 1A). We localize our entry point 1.0 mm right to lambda and just posterior (0.8 mm) to lambdoid suture (Fig 1B) so that large draining veins from posterior sinus can be avoided away from the target point [10]. …”

Section: Methodsmentioning

confidence: 99%

Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System

et al. 2017

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ObjectiveIn this work we set to develop and to validate a new in vivo frameless orthotopic Diffuse Intrinsic Pontine Glioma (DIPG) model based in the implantation of a guide-screw system.MethodsIt consisted of a guide-screw also called bolt, a Hamilton syringe with a 26-gauge needle and an insulin-like 15-gauge needle. The guide screw is 2.6 mm in length and harbors a 0.5 mm central hole which accepts the needle of the Hamilton syringe avoiding a theoretical displacement during insertion. The guide-screw is fixed on the mouse skull according to the coordinates: 1mm right to and 0.8 mm posterior to lambda. To reach the pons the Hamilton syringe is adjusted to a 6.5 mm depth using a cuff that serves as a stopper. This system allows delivering not only cells but also any kind of intratumoral chemotherapy, antibodies or gene/viral therapies.ResultsThe guide-screw was successfully implanted in 10 immunodeficient mice and the animals were inoculated with DIPG human cell lines during the same anesthetic period. All the mice developed severe neurologic symptoms and had a median overall survival of 95 days ranging the time of death from 81 to 116 days. Histopathological analysis confirmed tumor into the pons in all animals confirming the validity of this model.ConclusionHere we presented a reproducible and frameless DIPG model that allows for rapid evaluation of tumorigenicity and efficacy of chemotherapeutic or gene therapy products delivered intratumorally to the pons.

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Three-dimensional stereotactic atlas of the adult human skull correlated with the brain, cranial nerves, and intracranial vasculature

Cited by 17 publications

References 11 publications

From chalkboard, slides, and paper to e‐learning: How computing technologies have transformed anatomical sciences education

From chalkboard, slides, and paper to e‐learning: How computing technologies have transformed anatomical sciences education

Toward the holistic, reference, and extendable atlas of the human brain, head, and neck

Development of a DIPG Orthotopic Model in Mice Using an Implantable Guide-Screw System

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