Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

Razaky, Osama El; Amrousy, Doaa El; Elrifaey, Shaymaa; Elgendy, Marwa M; Ibrahim, Wesam A.

doi:10.1111/echo.14095

Cited by 12 publications

(15 citation statements)

References 30 publications

(55 reference statements)

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“…From our results, HbA1c was a significant predictor for the decrease in GLS. Similar correlation of HgbA1C with GLS derived by 3D speckle tracking was found in early diabetes as well . Although the utility of 2D STE is well established, it is limited by foreshortened views, geometric modeling, and out of the plane motion of the speckles.…”

Section: Discussionsupporting

confidence: 66%

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Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two‐dimensional speckle tracking study

Rakha

Aboelenin

2019

Pediatr Diabetes

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Background Cardiac dysfunction is a complication of type 1 diabetes mellitus (T1DM) with primary concern in adults. However, studies have evaluated left ventricle (LV) myocardial changes in pediatrics but not the long‐term effect of T1DM in such vulnerable age. Therefore, we assessed LV functions in pediatric patients with long‐duration T1DM using different echocardiographic modalities. Methods Between July 2015 and March 2016, 48 T1DM patients were prospectively compared to 35 healthy controls. Pediatric patients with T1DM for 10 years or more were included in the study. Patients were subjected to history taking, clinical examination, glycated hemoglobin (HbA1c), and microalbuminuria measurements. Moreover, conventional echocardiography, tissue Doppler, and 2D speckle tracking were performed to analyze LV functions. Results Mean age of patients was 15.5 ± 2 years, and mean T1DM duration was 11.7 ± 1.8 years. LV dimensions, EF and FS, and mass index did not statistically differ between groups, but E/E′ ratio was significantly higher in the diabetic group. Global longitudinal strain (GLS) and global circumferential strain (GCS) were significantly lower in diabetic patients compared with controls (P = 0.038; P = 0.001, respectively). Mean HbA1c was found to be a significant predictor of decreased GLS in the diabetic population (95% CI, 0.096‐0.244; P = 0.001) but not predicting GCS. Microalbuminuria had no significance in predicting strain. Conclusions Despite the long‐duration of affection with T1DM during childhood in our patients, alterations on LV myocardial function could not be detected either clinically or by conventional echocardiography. Tissue Doppler and speckle tracking could be used in the follow up of myocardial status in pediatric diabetic patients.

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Section: Discussionsupporting

confidence: 66%

“…Although the utility of 2D STE is well established, it is limited by foreshortened views, geometric modeling, and out of the plane motion of the speckles. Better accuracy may be acquired using 3D speckle tracking …”

Section: Discussionmentioning

confidence: 99%

Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two‐dimensional speckle tracking study

Rakha

Aboelenin

2019

Pediatr Diabetes

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“…It bases on a speckle tracking imaging technique and 4‐track intra‐myocardial echo spots by automatically analyzing myocardial longitudinal and circumferential areas, as well as the radial strain and strain rate, to identify slight differences of strain in space and time in each myocardial segment . In addition, 4DSTE can evaluate global and regional myocardial deformation or strain as well as early myocardial dysfunction in numerous systemic diseases …”

Section: Discussionmentioning

confidence: 95%

Predictive value of left ventricular myocardial strain by four‐dimensional speckle tracking echocardiography combined with red cell distribution width in heart failure with preserved ejection fraction

et al. 2019

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Objectives The diagnostic difficulty of heart failure with preserved ejection fraction (HFpEF) is differentiating it in patients with similar symptoms and signs. This study aimed to assess the potential predictive value of left ventricular global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), and global area strain (GAS) measured by four‐dimensional speckle tracking echocardiography (4DSTE) combined with red cell distribution width (RDW) in patients with HFpEF. Methods One hundred and sixty‐nine patients with symptoms or signs indicative of chronic heart failure and a left ventricular ejection fraction (LVEF) ≥ 50% and fifty controls with normal LVEF were recruited in this study. Standard echocardiography and 4DSTE examinations were performed. Laboratory examinations including RDW were performed on the same day as the echocardiographic study. Results GLS, GCS, GRS, and GAS in the patient cohort were significantly lower, and RDW was significantly higher than those in the control cohort (P < 0.01), and the strain parameters in definite HFpEF patients were also dramatically lower than the rest patients (P < 0.01). The associations of age, gender, NYHA classification, hypertension history, left ventricular end‐diastolic volume index, interventricular septal thickness, and diastolic dysfunction with HFpEF were significantly improved by adding 4DSTE parameters (P < 0.01) and further improved by adding RDW (P < 0.01). Conclusions In suspected HFpEF patients, who have symptoms or signs of heart failure, even without other conventional evidence of this diagnosis, GLS, GRS, and GCS have potential independent predictive value, while RDW has independent incremental predictive value for HFpEF.

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“…A TDI-alapú mérések T1DM-populációban megtartott bal kamrai longitudinális szisztolés funkciót is igazoltak (11,25). A speckle tracking technika ennél érzékenyebbnek bizonyult: a globális longitudinális strain (GLS) és globális cirkumferenciális strain (GCS) csökkenését számos kutatás igazolta fiatal, tünetmentes T1DM-betegekben (26)(27)(28)(29).…”

Section: Bal Kamrai Szisztolés Funkció Szubklinikus Károsodásaunclassified

“…eredményei alapján hagyományos echokardiográfiás vizsgálattal észrevehetetlen, korai bal kamrai szisztolés diszfunkció mutatható ki 3D speckle tracking technika segítségével tünetmentes T1DM-es gyermekekben (28). Hasonlóképpen, kutatásai során fiatal T1DM-páciensek bal kamrai GLS-e szignifikánsan alacsonyabbnak bizonyult az azonos ejekciós frakciójú egészséges kontrollokkal összehasonlítva (26).…”

Section: Bal Kamrai Szisztolés Funkció Szubklinikus Károsodásaunclassified

A szívizom-diszfunkció echokardiográfiás vizsgálata diabéteszben

Hajdu¹,

Knutsen²,

Faludi³

2021

Cardiologia Hungarica

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Three‐dimensional speckle tracking echocardiography: Is it the magic wand in the diagnosis of subclinical myocardial dysfunction in children with type 1 diabetes mellitus?

Abstract: 3D-STE is a good tool for prediction of early cardiac dysfunction in asymptomatic children with type 1 DM.

Cited by 12 publications

References 30 publications

Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two‐dimensional speckle tracking study

Left ventricular functions in pediatric patients with ten years or more type 1 diabetes mellitus: Conventional echocardiography, tissue Doppler, and two‐dimensional speckle tracking study

Predictive value of left ventricular myocardial strain by four‐dimensional speckle tracking echocardiography combined with red cell distribution width in heart failure with preserved ejection fraction

A szívizom-diszfunkció echokardiográfiás vizsgálata diabéteszben

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