Three-dimensional soft tissue analysis of the hand: a novel method to investigate effects of acromegaly

Hoevenaren, Inge A.; Wagenmakers, M. A. E. M.; Roerink, Sean H.P.P.; Netea‐Maier, Romana T.; Ulrich, Dietmar; Maal, T.J.J.

doi:10.1007/s00238-016-1217-3

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…In 2016, a multi-centre study compared the hands of acromegaly patients who underwent surgery over 2 years ago with the hands of matched normal people. The results showed that even after a recovery period of at least 2 years, the finger length and width of acromegaly patients remained significantly different from those of individuals in the normal group (19). However, these studies could not answer questions about how patients changed after surgery.…”

Section: Discussionmentioning

confidence: 83%

Long-term facial changes and clinical correlations in patients with treated acromegaly: a cohort study

Qiao

Wang

et al. 2021

European Journal of Endocrinology

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Background: Facial abnormality is the most significant feature in acromegaly patients. However, it is unclear whether and how patient facial appearance improves after treatment. This study aimed to identify 3D facial changes in acromegaly patients after surgical treatment. Methods: This study included 30 acromegaly patients who underwent resection of a pituitary GH adenoma. The location and extent of facial changes were identified by comparing baseline and 2-year follow-up 3D images of the face. Relationships between facial changes and GH and IGF-1 were evaluated with simple or multivariable linear regression models. Results: Significant soft tissue improvements were observed in acromegaly patients with complete remission, especially in the nose and lip region. Significant reductions in nasal width (3.46 mm, p < 0.001), tip protrusion (1.18 mm, p=0.003), face curve length (3.89 mm, p=0.004) and vermilion area (1.42 cm3, p=0.001) were observed at the 2-year follow-up. Further, changes in nasal width were associated with decreases in GH (β=4.440, p=0.017), the GH nadir (β=4.393, p=0.011) and IGF-1 (β=5.263, p=0.002). The associations were maintained after adjusting for confounders. Conclusions: Acromegaly patients achieved considerable facial improvements after surgical treatment. The change in nose width was associated with GH and IGF-1 decreases. Better control of patient hormone levels after surgery improves patient facial recovery.

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Section: Discussionmentioning

confidence: 83%

Long-term facial changes and clinical correlations in patients with treated acromegaly: a cohort study

Qiao

Wang

et al. 2021

European Journal of Endocrinology

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“…For the first time, ( 16 ) applied the 3D stereophotograph to the facial analysis of post-treatment acromegaly patients. In addition, 3D stereophotography could also be used in the evaluation of the acromegalic extremities ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

3D Facial Analysis in Acromegaly: Gender-Specific Features and Clinical Correlations

et al. 2018

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Objective: Quantitative investigations of facial changes in acromegaly are rare. A new imaging technique, three-dimensional (3D) stereophotography, can accurately quantify whole facial changes. We aimed to measure facial characteristics in acromegaly patients using 3D stereophotography, analyze gender-specific features, and explore clinical influencing factors.Design: Single-center case-control study.Methods: Thirty-nine acromegaly patients and 39 age- and gender-matched healthy subjects were prospectively enrolled. 3D stereophotography was performed, and facial lines and angles were quantified for each subject. Clinical information for each acromegaly patient was acquired.Results: The nose width, length, height and depth were longer; the upper and lower lips were thicker; the face length, face width and gonion-gnathion distances were longer; and the nasofrontal and columella-labial angles were smaller in the acromegaly patients, especially in males, than in the healthy controls, with statistical significance (p < 0.05). No differences were found in the face breadth, columella-labial angle, or nose length, height or depth between the female patient and healthy control groups. The insulin-like growth factor 1 (IGF-1) levels in the acromegaly patients were linearly and positively correlated with the nose width (p = 0.006) and gonion-gnathion distance (p = 0.029) and linearly and negatively correlated with the nasofrontal angle (p = 0.026).Conclusions: The acromegaly patients' facial changes exhibit a unique trend, and the characteristics are not identical between genders. 3D stereophotography is an accurate and reliable tool for investigating facial characteristics. Recognizing the above facial features might be potential to assist in the early diagnosis and timely treatment of acromegaly and aid in predicting the severity of systemic complications.

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“…24 identifiable landmarks were chosen based on Hoevenaren et al ' study of 3D hand photograph 7 (Table 1), which has proven that intra-and inter-observer reproducibility of the most of these landmarks were high. A series of linear measurements based on the landmarks were chosen for comparative measurements (Table 2), according the standard used by Yu et al 1 and Hoevenaren et al 20 .…”

Section: Methods 3d Photographs Of Gemini Structured Light-scanningmentioning

confidence: 99%

Evaluating the accuracy of hand models obtained from two 3D scanning techniques

Yu¹,

Zeng²,

Ding³

et al. 2020

Sci Rep

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The aim of this study was to identify an efficient approach for 3D imaging of hand. The 3D photographs of hand were taken with Gemini structured-light scanning system (SL scanning) and CT scanning. The 3D photographs, average time of scanning and reconstruction were compared between these two indirect techniques. The reliability, reproducibility and accuracy were evaluated in these two indirect techniques and the direct measurement (DM). Statistical differences in the measurements were assessed by 99% probability, with clinical significance at > 0.5 mm. The Gemini structured-light scanning system established a complete and smooth 3D hand photograph with shorter scanning and reconstruction time. Reproducibility of CT scanning and SL scanning methods was better (P < 0.01, both) than the DM, but did not differ significantly from each other (P = 0.462). Of the 19 (31.58%) measurements obtained, 6 showed significant differences (P < 0.01). Significant differences were observed more often for circumference dimensions (5/9, 55.56%) than for length dimensions (1/10, 10%). Mean absolute error (AE) of the 10 subjects was very low for 3D CT (0.29 ± 0.10 mm) and SL scanning (0.30 ± 0.11 mm). Absolute percentage error (APE) was 4.69 ± 2.33% and 4.88 ± 2.22% for 3D CT and SL scanning, respectively. AE for the PIP circumference between the 3rd finger (0.58 mm) and 4th finger (0.53 mm) scan was > 0.5 mm, indicating significant difference between DM and CT scanning at the level of 99% probability. In this study, the Gemini structured-light scanning system not only successfully established a complete and smooth 3D hand photograph, but also shortened the scanning and reconstruction time. Compared to the DM, measurements obtained using the two indirect techniques did not show any statistically or clinically insignificant difference in the values of the remaining 17 of 19 measurements (89.47%). Therefore, either of the two alternative techniques could be used instead of the direct measurement method.

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Three-dimensional soft tissue analysis of the hand: a novel method to investigate effects of acromegaly

Cited by 9 publications

References 20 publications

Long-term facial changes and clinical correlations in patients with treated acromegaly: a cohort study

Long-term facial changes and clinical correlations in patients with treated acromegaly: a cohort study

3D Facial Analysis in Acromegaly: Gender-Specific Features and Clinical Correlations

Evaluating the accuracy of hand models obtained from two 3D scanning techniques

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