Three-dimensional quantitative micro-elastography reveals alterations in spatial elasticity patterns of follicles and corpora lutea in murine ovaries during ageing
Anna Jaeschke,
Matt S. Hepburn,
Alireza Mowla
et al.
Abstract:Fibrosis and tissue stiffening are hallmarks of ovarian ageing, linked to a decrease in fertility. However, the lack of three-dimensional (3D) characterization of ovary elasticity limits our understanding of localized elasticity patterns and their connection to the tissue composition. Here, we developed an integrated approach to link ovarian tissue elasticity, volume, and cell-matrix composition using quantitative micro-elastography (QME), a label-free, non-invasive approach to study the 3D microscale elastici… Show more
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