Three-dimensional Proton MR Spectroscopy of Human Prostate at 3 T without Endorectal Coil: Feasibility

Scheenen, Tom W. J.; Heijmink, Stijn W. T. P. J.; Roell, Stefan; Kaa, Christina A. Hulsbergen‐van de; Knipscheer, Ben C.; Witjes, J. Alfred; Barentsz, Jelle O.; Heerschap, Arend

doi:10.1148/radiol.2451061444

Cited by 116 publications

(96 citation statements)

References 23 publications

(30 reference statements)

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“…A 3D weighted k-space acquisition with dual-frequency selective refocusing pulses to suppress water and lipid signals was used. 8 The surrounding lipid tissues were additionally suppressed by manual placement of saturation slabs. The nominal voxel size was kept constant in all measurements at 8 3 8 3 8 mm 3 by adapting the matrix size and the field of view to every patient.…”

Section: Mr Spectroscopymentioning

confidence: 99%

“…Zero filling and filtering of the MR spectroscopy matrix artificially increase the spatial resolution beyond the actual spatial resolution of the measurement. 8 Dynamic contrast-enhanced MRI Dynamic contrast-enhanced (DCE) MRI was conducted using a 3D axial gradient echo sequence (Table 1). 20 acquisitions of 72 slices each requiring 23 s per acquisition were obtained before and after the administration of gadolinium-based contrast medium.…”

Section: Mr Spectroscopymentioning

confidence: 99%

See 1 more Smart Citation

Multiparametric MRI of the prostate with three functional techniques in patients with PSA elevation before initial TRUS-guided biopsy

Hauth¹,

Hohmuth

Cozub-Poetica³

et al. 2015

BJR

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Section: Mr Spectroscopymentioning

confidence: 99%

Section: Mr Spectroscopymentioning

confidence: 99%

Multiparametric MRI of the prostate with three functional techniques in patients with PSA elevation before initial TRUS-guided biopsy

Hauth¹,

Hohmuth

Cozub-Poetica³

et al. 2015

BJR

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“…MRSI calculates the choline/citrate (C/C) ratio and determines the degree of aggressiveness of the cancer dependent on the C/C ratio. [25][26][27][28] However, when 1.5T magnet devices are used, this process takes 13-20 min., and assessment is rather complex and requires additional training and expertise. For this reason, its use in routine urology practice is rather limited and it is usually used for research purposes.…”

Section: Mr Spectroscopy Imagingmentioning

confidence: 99%

Multiparametric magnetic resonance imaging: Overview of the technique, clinical applications in prostate biopsy and future directions

Demirel

Davis

2018

Turkish Journal of Urology

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Multiparametric magnetic resonance imaging (mpMRI) has managed to change the paradigms on prostate cancer detection and risk classification. The most clear-cut indication of mpMRI in guidelines is the patients with a history of negative biopsy/increasing prostate-specific antigen (PSA), and presence of additional findings supporting its use in non biopsied patients and active surveillance. mpMRI complements standard clinical exam, PSA measurements, and systematic biopsy, and will miss some tumors that lack enough size or change in tissue density. Use of mpMRI is likely to increase, and further developments in the technique will be important for safe adoption of focal therapy concepts. Here we present a brief summary about mpMRI and its use in detection, risk classification and follow-up of prostate cancer.

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“…Magnetic Resonance Spectroscopy (MRS) has demonstrated a high level of ability to differenciate prostate tissue from Cancer [1] and it is now feasible without endorectal coil [2,3]at higher magnetic fields (≥ 3T) one more time for patient comfort. Three-dimensional proton (3D 1H) Magnetic Resonance Spectroscopic Imaging (MRSI) of the entire gland displays relative concentrations of metabolites, particularly citrate and choline (Fig.…”

Section: Introductionmentioning

confidence: 99%

Classification of prostate magnetic resonance spectra using Support Vector Machine

Parfait

Walker

Créhange

et al. 2012

Biomedical Signal Processing and Control

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Prostate cancer is the most common cancer in men over 50 years of age and it has been shown that nuclear magnetic resonance spectra are sensitive enough to distinguish normal and cancer. In this paper, we propose a classification technique of spectra from magnetic resonance spectroscopy. We studied automatic classification with and without quantification of metabolite signals. The dataset is composed of 22 patient datasets with a biopsy-proven cancer, from which we extracted 2464 spectra from the whole prostate and of which 1062 were localised in the peripheral zone. The spectra were manually classed into 3 different categories by a spectroscopist with 4 years experience in clinical spectroscopy of prostate cancer: undetermined, healthy and pathologic. We used different preprocessing methods (module, phase correction only, phase correction and baseline correction) as input for Support Vector Machine and for Multilayer Perceptron, and we compared the results with those from the expert. If we class only healthy and pathologic spectra we reach a total error rate of 4.51%. However, if we class all spectra (undetermined, healthy and pathologic) the total error rate rises to 11.49%. We have shown in this paper that the best results are obtained using the * Corresponding author * * Principal corresponding author Email addresses: sebastien.parfait@u-bourgogne.fr (S. Parfait), johel.miteran@u-bourgogne.fr (J. Mitéran) Preprint submitted to Biomedical Signal Processing and ControlDecember 12, 2011 pre-processed spectra without quantification as input for the classifiers and we confirm that Support Vector Machine are more efficient than Multilayer Perceptron in processing high dimensional data.

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Three-dimensional Proton MR Spectroscopy of Human Prostate at 3 T without Endorectal Coil: Feasibility

Abstract: Three-dimensional proton MR spectroscopy of the prostate, with a combination of only external radiofrequency surface coils at 3 T, can be used to discriminate cancer from healthy tissue.

Cited by 116 publications

References 23 publications

Multiparametric MRI of the prostate with three functional techniques in patients with PSA elevation before initial TRUS-guided biopsy

Multiparametric MRI of the prostate with three functional techniques in patients with PSA elevation before initial TRUS-guided biopsy

Multiparametric magnetic resonance imaging: Overview of the technique, clinical applications in prostate biopsy and future directions

Classification of prostate magnetic resonance spectra using Support Vector Machine

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