Three-Dimensional Printing: A Catalyst for a Changing Orthopaedic Landscape

Minto, J.; Zhou, Xuan; Osborn, Jenna; Zhang, Lijie Grace; Sarkar, Kausik; Rao, Raj D.

doi:10.2106/jbjs.rvw.19.00076

Cited by 20 publications

(15 citation statements)

References 106 publications

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“…3D printing has undergone rapid progression over the past 10 years as the cost of 3D printers and materials has drastically decreased. 13,14 Before this, CT scans were utilized to create virtual 3D modeling to plan for PAOs. One of the earliest reports was performed by the group out in Berne in 1988, where they utilized CT scans to evaluate femoral coverage and joint congruency in hips undergoing PAOs.…”

Section: Discussionmentioning

confidence: 99%

Use of 3D Printed Models to Determine Accurate Bone Cuts during a Periacetabular Osteotomy for Developmental Hip Dysplasia

Driesman

Buchalter

Kirby

et al. 2021

The Journal of Hip Surgery

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The periacetabular osteotomy (PAO) is a powerful tool to delay the progression of hip arthritis by reorienting the acetabulum. This study aimed to use three-dimensional (3D)-printed models of the pelvis, reconstructed from the computed tomography (CT) scans of patients, to model how the level of dysplasia and its location ilium osteotomy affect radiographic outcomes following PAO. This pilot study aims to determine if preoperative 3D printing/planning can assist in predicting radiographic outcomes. We performed a retrospective review of five patients with differing levels of hip dysplasia for whom we had obtained CT scans before PAO surgery. For each patient, we printed two pelvis models that would undergo standardized cuts of the PAO procedure, with variations only in the distance of the ilium start point (one-third of the distance between the anterior superior iliac spine and anterior inferior iliac spine [AIIS] vs. two-thirds of the distance). We then mobilized the acetabular fragment into eight reproducible positions in space by moving the ilium cut a combination of 0, 1, or 2 cm anterior/lateral. Each position of the newly realigned acetabula was examined under fluoroscopy to obtain a standardized anteroposterior view, and to obtain standardized radiographic measurements in the form of lateral center edge angle (CEA), acetabular depth, Tonnis angle, and acetabular inclination. We performed 80 simulations of the PAO with varying degrees of acetabular mobilization. On average, in the models where the supra-acetabular cut was closer to the AIIS, we found more significant degrees of radiographic correction, regarding Tonnis angles (12.91 vs. 7.95, p = 0.0175), acetabular inclination (20.25 vs. 9.875, p = 0.027), and lateral CEA (11.75 vs. 2.5, p = 0.061). Patients who had greater dysplasia also had more significant degrees of radiographic Tonnis angle correction with the same mobilization movements of the acetabula (p = 0.005). When utilizing 3D printing to model PAO in dysplasia pelvises, we found that both a higher level of preoperative dysplasia and starting the supra-acetabular osteotomy closer to the AIIS were associated with more powerful corrections following smaller manipulations.

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Section: Discussionmentioning

confidence: 99%

Use of 3D Printed Models to Determine Accurate Bone Cuts during a Periacetabular Osteotomy for Developmental Hip Dysplasia

Driesman

Buchalter

Kirby

et al. 2021

The Journal of Hip Surgery

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“…Titanium alloy has been extensively used in the medical fields of orthopedics, dentistry, and vascular surgery owing to its high strength, low density, high corrosion resistance, and excellent biocompatibility ( Domínguez-Trujillo et al, 2018 ). Traditional titanium alloy implants have been manufactured by iso-material mold casting or subtractive technologies such as machining, multipoint forming and NC machining ( Minto et al, 2020 ; Khorasani et al, 2016 ; Herzog and Tille 2021 ; Markopoulos et al, 2018 ). Hence, they are difficult to simulate the structure of cortical bone and cancellous bone in real bone tissue ( Bozkurt and Karayel, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Compared to traditional implant manufacturing methods, 3D-printed technology has two advantages. In terms of microstructure, 3D-printed technology can precisely control the Young’s modulus of the prosthesis to match natural bone by predesigned pores that can effectively reduce the stress shielding effect of the implant and reduce the incidence of peri implant osteolysis ( Minto et al, 2020 ). In terms of macro structure, implant shape can be designed with 3D-printed technology, accurately matching the complex bone defect through computed tomography (CT) images, so as to achieve the dual adaptation of the mechanical properties and shapes of the implant to the natural bone tissue ( Wong, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Sheng

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the development of three-dimensional (3D) printed technology, 3D printed alloy implants, especially titanium alloy, play a critical role in biomedical fields such as orthopedics and dentistry. However, untreated titanium alloy implants always possess a bioinert surface that prevents the interface osseointegration, which is necessary to perform surface modification to enhance its biological functions. In this article, we discuss the principles and processes of chemical, physical, and biological surface modification technologies on 3D printed titanium alloy implants in detail. Furthermore, the challenges on antibacterial, osteogenesis, and mechanical properties of 3D-printed titanium alloy implants by surface modification are summarized. Future research studies, including the combination of multiple modification technologies or the coordination of the structure and composition of the composite coating are also present. This review provides leading-edge functionalization strategies of the 3D printed titanium alloy implants.

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“…(Brunelli et al, 2019;Pörtner et al, 2005). Pressure modulating bioreactors using low-intensity pulsed ultrasound (LIPUS) were also developed to stimulate osteoblastic and chondrogenic differentiation (Aliabouzar et al, 2018(Aliabouzar et al, , 2016Katiyar et al, 2014;Minto et al, 2020;Osborn et al, 2019;Zhou et al, 2016). Finally, hydrostatic pressure (HP) stimulation on cultured cells has also been achieved by compressing the gas phase above an incompressible media (Gardinier et al, 2009;Henstock et al, 2013;Liu et al, 2010;Reinwald et al, 2015;Reinwald and El Haj, 2018;Stavenschi et al, 2018;Zhao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering

Pelling

2021

Preprint

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Accurate physical representation of the tissue microenvironment is essential for implant development. In this study, we applied cyclic hydrostatic pressure (HP) to mimic the effect of cyclic hydrostatic pressure (HP) in a bone-like environment, using a custom-made, remote controlled bioreactor. In recent years, plant-derived cellulosic biomaterials have become a popular way to create scaffolds for a variety of tissue engineering applications. Moreover, such scaffolds possess similar physical properties (porosity, stiffness) that resemble bone tissues and have been explored as potential biomaterials for tissue engineering applications. Here, plant-derived cellulose scaffolds (derived from apple hypanthium tissue) were seeded with MC3T3-E1 pre-osteoblast cells. After 1 week of proliferation, cell-seeded scaffolds were exposed to HP up to 270 KPa at a frequency of 1Hz, once per day, for up to 2 weeks. Scaffolds were incubated in osteogenic inducing media or regular culture media. The effect of cyclic hydrostatic pressure combined with osteogenic inducing media on cell-seeded scaffolds resulted in an increase of differentiated cells. This corresponded with an upregulation of alkaline phosphatase activity and scaffold mineralization. The results reveal that in vitro, the mechanosensitive pathways which regulate osteogenesis appear to be functional on novel plant-derived cellulosic biomaterials.

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Three-Dimensional Printing: A Catalyst for a Changing Orthopaedic Landscape

Cited by 20 publications

References 106 publications

Use of 3D Printed Models to Determine Accurate Bone Cuts during a Periacetabular Osteotomy for Developmental Hip Dysplasia

Use of 3D Printed Models to Determine Accurate Bone Cuts during a Periacetabular Osteotomy for Developmental Hip Dysplasia

Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization

Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering

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