Three-Dimensional Printing (3DP) of neonatal head phantom for ultrasound: Thermocouple embedding and simulation of bone

Gatto, Matteo; Memoli, Gianluca; Shaw, Adam; Sadhoo, Neelaksh; Gélat, Pierre; Harris, Russell A.

doi:10.1016/j.medengphy.2011.10.012

Cited by 20 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is significant in terms of the development of medical applications for specific patients. 3D printing can be achieved either directly (where the phantom is printed) or indirectly (where the casting mold is printed and other materials are used to build the phantom) …”

Section: Introductionmentioning

confidence: 99%

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

2018

View full text Add to dashboard Cite

Purpose: Printing technology, capable of producing three-dimensional (3D) objects, has evolved in recent years and provides potential for developing reproducible and sophisticated physical phantoms. 3D printing technology can help rapidly develop relatively low cost phantoms with appropriate complexities, which are useful in imaging or dosimetry measurements. The need for more realistic phantoms is emerging since imaging systems are now capable of acquiring multimodal and multiparametric data. This review addresses three main questions about the 3D printers currently in use, and their produced materials. The first question investigates whether the resolution of 3D printers is sufficient for existing imaging technologies. The second question explores if the materials of 3D-printed phantoms can produce realistic images representing various tissues and organs as taken by different imaging modalities such as computer tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), and mammography. The emergence of multimodal imaging increases the need for phantoms that can be scanned using different imaging modalities. The third question probes the feasibility and easiness of "printing" radioactive or nonradioactive solutions during the printing process. Methods: A systematic review of medical imaging studies published after January 2013 is performed using strict inclusion criteria. The databases used were Scopus and Web of Knowledge with specific search terms. In total, 139 papers were identified; however, only 50 were classified as relevant for this paper. In this review, following an appropriate introduction and literature research strategy, all 50 articles are presented in detail. A summary of tables and example figures of the most recent advances in 3D printing for the purposes of phantoms across different imaging modalities are provided. Results: All 50 studies printed and scanned phantoms in either CT, PET, SPECT, mammography, MRI, and US-or a combination of those modalities. According to the literature, different parameters were evaluated depending on the imaging modality used. Almost all papers evaluated more than two parameters, with the most common being Hounsfield units, density, attenuation and speed of sound. Conclusions: The development of this field is rapidly evolving and becoming more refined. There is potential to reach the ultimate goal of using 3D phantoms to get feedback on imaging scanners and reconstruction algorithms more regularly. Although the development of imaging phantoms is evident, there are still some limitations to address: One of which is printing accuracy, due to the printer properties. Another limitation is the materials available to print: There are not enough materials to mimic all the tissue properties. For example, one material can mimic one property-such as the density of real tissue-but not any other property, like speed of sound or attenuation.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

2018

View full text Add to dashboard Cite

show abstract

“…Gatto et al . proposed a head model based on 3D printing and applied it to ultrasound imaging 20 , wherein the main focus of the study involved the ultrasound properties of the model. Regarding brain EIT, the ideal method to correctly replicate the complex resistivity distribution of the human head is an important prerequisite for constructing the EIT head phantom using 3D printing.…”

Section: Introductionmentioning

confidence: 99%

A novel 3D-printed head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution for electrical impedance tomography

Zhang

Yang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Phantom experiments are an important step for testing during the development of new hardware or imaging algorithms for head electrical impedance tomography (EIT) studies. However, due to the sophisticated anatomical geometry and complex resistivity distribution of the human head, constructing an accurate phantom for EIT research remains challenging, especially for skull modelling. In this paper, we designed and fabricated a novel head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution based on 3D printing techniques. The skull model was constructed by simultaneously printing the distinct layers inside the skull with resistivity-controllable printing materials. The entire phantom was composed of saline skin, a 3D-printed skull, saline cerebrospinal fluid (CSF) and 3D-printed brain parenchyma. The validation results demonstrated that the resistivity of the phantom was in good agreement with that of human tissue and was stable over time, and the new phantom performed well in EIT imaging. This paper provides a standardized, efficient and reproducible method for the construction of a head phantom for EIT that could be easily adapted to other conditions for manufacturing head phantoms for brain function research, such as transcranial direct current stimulation (TDCS) and electroencephalography (EEG).

show abstract

“…The data is within the range of published acoustic values for human skull and brain tissue by Gatto (1528 m/s for brain tissue and 5-7 dB/cm for neonatal skull). [4] Since acoustic testing showed that the Z510 is capable of printing material with similar acoustic properties of real skulls, a full phantom will be developed for imaging and planning.…”

Section: Phantom Analysis Resultsmentioning

confidence: 99%

Porcine pilot study of MRI-guided HIFU treatment for neonatal intraventricular hemorrhage (IVH)

Looi¹,

Waspe²,

Mougenot³

et al. 2012

AIP Conference Proceedings

View full text Add to dashboard Cite

Abstract. Intraventricular hemorrhage (IVH) occurs in 15% of premature babies and 50% of IVH cases progress to posthemorrhagic ventricular dilation due to large blood clots forming in the ventricles. Existing treatments such as tissue plasminogen activator (tPA) and surgical intervention have severe side effects in paediatric patients that include excessive bleeding and complications. This study investigates the feasibility of MR-HIFU for sonothrombolysis of blood clots from IVH using natural acoustic windows, known as fontanelles, in the skulls of newborns. The study involved 2 elements: a phantom study to examine beam limitations and acoustic properties, and an in-vivo porcine study. A phantom skull was created from sample patient data and was used to analyze reachability of the Philips Sonavelle system. Acoustic measurements of the phantom (attenuation of 5-14 dB and speed of sound of 1722-2965 m/s) indicated the phantom effectively mimics neonatal skull bone. For the ex-vivo studies, a porcine clot was created and sonicated for 5 mins at 500W with a 0.5% duty cycle. For the in-vivo experiment, a vertex craniotomy was performed and porcine blood was injected into the lateral ventricle under ultrasound guidance. Sonication using the prior parameters induced cavitation and post-sonication T 1 and T 2 images verified clot lysis. Further H&E analysis showed no presence of blood in the ventricles. These positive results show that MR-HIFU has potential as a noninvasive tool for sonothrombolysis of neonatal IVH clots.

show abstract

Three-Dimensional Printing (3DP) of neonatal head phantom for ultrasound: Thermocouple embedding and simulation of bone

Cited by 20 publications

References 18 publications

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

A novel 3D-printed head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution for electrical impedance tomography

Porcine pilot study of MRI-guided HIFU treatment for neonatal intraventricular hemorrhage (IVH)

Contact Info

Product

Resources

About