Three dimensional poly(ε-caprolactone) and silk fibroin nanocomposite fibrous matrix for artificial dermis

Lee, Jung Min; Chae, Taesik; Sheikh, Faheem A.; Ju, Hyung Woo; Moon, Bo Mi; Park, Hyun Jung; Park, Ye Ri; Park, Chan Hum

doi:10.1016/j.msec.2016.06.019

Cited by 81 publications

(43 citation statements)

References 36 publications

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“…Modifying sling properties using tissue engineering seems promising. Various natural or synthetic polymers have been fabricated into engineered scaffolds using the electrospinning method to repair many different types of tissues . Ideal engineered scaffolds should mimic the native ECM to support cell adhesion, proliferation and differentiation, thereby facilitating tissue formation.…”

Section: Discussionmentioning

confidence: 99%

“…Promising as electrospinning technique is, the fabrication of scaffolds with controlled 3D property remains a problem, due to its nature of layer by layer deposition pattern of the nanofibers. To solve this problem, previous methods have included salt leaching, ice crystal formation, sacrificial fibers or increasing the fiber diameter . However, these methods decreased the mechanical strength and inhibited the cell growth.…”

Section: Discussionmentioning

confidence: 99%

“…To solve this problem, previous methods have included salt leaching, ice crystal formation, sacrificial fibers or increasing the fiber diameter. 14,16 However, these methods decreased the mechanical strength and inhibited the cell growth.…”

Section: Discussionmentioning

confidence: 99%

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The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

Zhang

Cao

Guo

et al. 2017

Neurourology and Urodynamics

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

Zhang

Cao

Guo

et al. 2017

Neurourology and Urodynamics

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“…However, like PLA, the downside of PCL lies in its hydrophobic nature and lack of cell surface recognition sites. Together the relative positive and negative attributes of synthetic polymers means that co-polymerisation of various combinations of both synthetic and natural polymers has become an active area of research [389,391,393,394,395,396,397,398]. …”

Section: Biomaterialsmentioning

confidence: 99%

The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications

2017

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High sulfation, low cost, and the status of heparin as an already FDA- and EMA- approved product, mean that its inclusion in tissue engineering (TE) strategies is becoming increasingly popular. However, the use of heparin may represent a naïve approach. This is because tissue formation is a highly orchestrated process, involving the temporal expression of numerous growth factors and complex signaling networks. While heparin may enhance the retention and activity of certain growth factors under particular conditions, its binding ‘promiscuity’ means that it may also inhibit other factors that, for example, play an important role in tissue maintenance and repair. Within this review we focus on articular cartilage, highlighting the complexities and highly regulated processes that are involved in its formation, and the challenges that exist in trying to effectively engineer this tissue. Here we discuss the opportunities that glycosaminoglycans (GAGs) may provide in advancing this important area of regenerative medicine, placing emphasis on the need to move away from the common use of heparin, and instead focus research towards the utility of specific GAG preparations that are able to modulate the activity of growth factors in a more controlled and defined manner, with less off-target effects.

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“…Silk fibroin (SF) is a naturally occurring polymer, derived from Bombyx mori silkworm has been used in TE, due to its biocompatibility, low immunoreactivity, biodegradability, suitable oxygen and water vapor permeability, and good mechanical properties . Moreover, SF improves cell adhesion and proliferation for TE applications …”

Section: Introductionmentioning

confidence: 99%

Immobilization of silk fibroin on the surface of PCL nanofibrous scaffolds for tissue engineering applications

Khosravi

Ghasemi‐Mobarakeh

Mollahosseini

et al. 2018

J of Applied Polymer Sci

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Poly(E-caprolactone) (PCL) is explored in tissue engineering (TE) applications due to its biocompatibility, processability, and appropriate mechanical properties. However, its hydrophobic nature and lack of functional groups in its structure are major drawbacks of PCL-based scaffolds limiting appropriate cell adhesion and proliferation. In this study, silk fibroin (SF) was immobilized on the surface of electrospun PCL nanofibers via covalent bonds in order to improve their hydrophilicity. To this end, the surface of PCL nanofibers was activated by ultraviolet (UV)-ozone irradiation followed by carboxylic functional groups immobilization on their surface by their immersion in acrylic acid under UV radiation and final immersion in SF solution. Furthermore, morphological, mechanical, contact angle, and Attenuated total reflection-Fourier transform infrared (ATR-FTIR) were measured to assess the properties of the surfacemodified PCL nanofibers grafted with SF. ATR-FTIR results confirmed the presence of SF on the surface of PCL nanofibers. Moreover, contact angle measurements of the PCL nanofibers grafted with SF showed the contact angle of zero indicating high hydrophilicity of modified nanofibers. In vitro cell culture studies using NIH 3T3 mouse fibroblasts confirmed enhanced cytocompatibility, cell adhesion, and proliferation of the SF-treated PCL nanofibers.Silk fibroin (SF) is a naturally occurring polymer, derived from Bombyx mori silkworm has been used in TE, due to its biocompatibility, low immunoreactivity, biodegradability, suitable oxygen and water vapor permeability, and good mechanical properties. [14][15][16][17][18][19][20] Moreover, SF improves cell adhesion and proliferation for TE applications. 14,16 Combination of the two aforementioned polymers (PCL and SF) can be considered as a synthetic/natural polyblend to

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Three dimensional poly(ε-caprolactone) and silk fibroin nanocomposite fibrous matrix for artificial dermis

Cited by 81 publications

References 36 publications

The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications

Immobilization of silk fibroin on the surface of PCL nanofibrous scaffolds for tissue engineering applications

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