Three‐Dimensional Optoacoustic Monitoring of Lesion Formation in Real Time During Radiofrequency Catheter Ablation

Pang, Genny A.; Bay, Erwin; Deán‐Ben, Xosé Luís; Razansky, Daniel

doi:10.1111/jce.12584

Cited by 51 publications

(43 citation statements)

References 23 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We confirm the spectral signature observed by Dana et al [20], as well as the increase in signal from ablated tissue observed by Pang et al [19]. However, we find that the correlation based imaging proposed in [20] highlights also the artefacts caused by image reconstruction and that the correlation to non-ablated tissue remains high making it difficult at instances to identify lesions from the rest of the tissue.…”

Section: Contribution Of This Worksupporting

confidence: 90%

“…Two groups have previously performed PA imaging of RF ablation lesions on porcine cardiac tissue ex-vivo [19,20]. Pang et al [19] have identified a maximum lesion to nonablated tissue contrast at 780 nm using a 3 MHz transducer.…”

Section: Photoacoustic Imaging For Lesion Progression Monitoringmentioning

confidence: 99%

“…Pang et al [19] have identified a maximum lesion to nonablated tissue contrast at 780 nm using a 3 MHz transducer. Dana et al [20] revealed a spectral signature providing contrast at wavelengths near 760 nm (which was attributed to the hemoglobin spectral signature disappearing) using a 21 MHz transducer.…”

Section: Photoacoustic Imaging For Lesion Progression Monitoringmentioning

confidence: 99%

“…We introduce a dual wavelength (790/930 nm) imaging method which forms an image based on two consecutive frames acquired at two optical wavelengths. Advantages over single wavelength imaging approaches presented before [19,20] are insensitivity to fluence and temperature variations, resulting in more robust lesion detection, contrast and outlining (mainly transmurality). Quantitatively, we find that the best-performing single wavelength is 640 nm, in contrast to 780 nm that was suggested previously, based on qualitative assessment in single lesions [19].…”

Section: Contribution Of This Workmentioning

confidence: 99%

See 3 more Smart Citations

Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Iskander-Rizk¹,

Kruizinga²,

Steen³

et al. 2018

Biomed. Opt. Express

View full text Add to dashboard Cite

Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure's outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single-and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%. We compare this with a best single-wavelength (640 nm) analysis that correctly identifies 82% of lesions. We discuss the origin of relevant spectroscopic features and perspectives for translation to clinical imaging.

show abstract

Section: Contribution Of This Worksupporting

confidence: 90%

Section: Photoacoustic Imaging For Lesion Progression Monitoringmentioning

confidence: 99%

Section: Photoacoustic Imaging For Lesion Progression Monitoringmentioning

confidence: 99%

Section: Contribution Of This Workmentioning

confidence: 99%

See 2 more Smart Citations

Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Iskander-Rizk¹,

Kruizinga²,

Steen³

et al. 2018

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Another possible application could be volumetric temperature mapping, where photoacoustic imaging methods have been suggested for measuring the temperature at deep locations. [32][33][34][35] Direct thermographic imaging could offer a non-contact alternative technology.…”

Section: (A)]mentioning

confidence: 99%

Super-resolution thermographic imaging using blind structured illumination

Burgholzer

Berer

Gruber

et al. 2017

Applied Physics Letters

View full text Add to dashboard Cite

Using an infrared camera for thermographic imaging allows the contactless temperature measurement of many surface pixels simultaneously. From the measured surface data, the structure below the surface, embedded inside a sample or tissue, can be reconstructed and imaged, if heated by an excitation light pulse. The main drawback in active thermographic imaging is the degradation of the spatial resolution with the imaging depth, which results in blurred images for deeper lying structures. We circumvent this degradation by using blind structured illumination combined with a non-linear joint sparsity reconstruction algorithm. We demonstrate imaging of a line pattern and a star-shaped structure through a 3 mm thick steel sheet with a resolution four times better than the width of the thermal point-spread-function. The structured illumination is realized by parallel slits cut in an aluminum foil, where the excitation coming from a flashlight can penetrate. This realization of super-resolution thermographic imaging demonstrates that blind structured illumination allows thermographic imaging without high degradation of the spatial resolution for deeper lying structures. The groundbreaking concept of super-resolution can be transferred from optics to diffusive imaging by defining a thermal point-spread-function, which gives the principle resolution limit for a certain signal-to-noise ratio, similar to the Abbe limit for a certain optical wavelength. In future work, the unknown illumination pattern could be the speckle pattern generated by a short laser pulse inside a light scattering sample or tissue.

show abstract

Volumetric optoacoustic imaging feedback during endovenous laser therapy – an ex vivo investigation

Fehm

Deán‐Ben

Schaur

et al. 2015

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

Endovenous laser therapy (ELT) was introduced in clinical practice for treating incompetent veins about fifteen years ago. Despite the considerable clinical evidence collected so far, no rigorous guidelines are yet available regarding the optimal energy deposition protocols while incidence of recanalization, lack of vessel occlusion and collateral damage remains variable among patients. Online monitoring and feedback-based control over the lesion progression may improve clinical outcomes. Yet the currently employed monitoring tools, such as Doppler ultrasound, often do not provide sufficient contrast as well as three-dimensional imaging capacity for accurate lesion assessment during thermal treatments. Here we investigate on the utility of volumetric optoacoustic tomography for real-time monitoring of the ELT procedures. Experiments performed in subcutaneous veins of an ox foot model revealed the accurate spatio-temporal maps of the lesion progression and characteristics of the vessel wall. Optoacoustic images further correlated with the temperature elevation measured in the area adjacent to the coagulation spot and made it possible to track the position of the fiber tip during its pull back in real time and in all three dimensions. Overall, we showcase that volumetric optoacoustic tomography is a promising tool for providing online feedback during endovenous laser therapy.

show abstract

Three‐Dimensional Optoacoustic Monitoring of Lesion Formation in Real Time During Radiofrequency Catheter Ablation

Cited by 51 publications

References 23 publications

Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium

Super-resolution thermographic imaging using blind structured illumination

Volumetric optoacoustic imaging feedback during endovenous laser therapy – an ex vivo investigation

Contact Info

Product

Resources

About