Three-dimensional numerical simulation of the effects of fractal vascular trees on tissue temperature and intracelluar ice formation during combined cancer therapy of cryosurgery and hyperthermia

Wang, Zhen; Zhao, Gang; Wang, Tao; Yu, Qianfeng; Su, Min–Ying; He, Xiaoming

doi:10.1016/j.applthermaleng.2015.06.103

Cited by 31 publications

(10 citation statements)

References 41 publications

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“…Figure 2 also shows the thermocouple probes used to measure the temperature distribution of freezing region. Teflon channel is used to simulate the blood vessel due to its similarity to the blood vessel [5, 7,8,10,13]. Three different teflon channels with inner diameters (inner diameter=2.4 mm, 3.2 mm and 4.0 mm) are employed in order to examine the blood flow thermal effect.…”

Section: Methodsmentioning

confidence: 99%

“…Results show that injecting nanoparticles into tissue increases the freezing region volume. Wang et al [13] developed a multiscaled three-dimensional cell-tissue model in order to evaluate the effects of cardiovascular network thinking the conclusions acquired from hyperthermia and cryosurgery treatments. It was found that increasing the distance between the tumor and the vascular network results in increasing the tumor damage degree.…”

Section: Introductionmentioning

confidence: 99%

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Bio-heat transfer in cancer treatment using cryo-freezing method

Kizilirmak

Turgut

2021

Journal of Thermal Engineering

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The objective of this study is to investigate the effect of bio-heat transfer from large blood vessels on freezing region size of tumorous liver tissue using cryo-freezing method. Bio-heat transfer, one of the cancer treatment method, in tumorous tissue has been investigated experimentally using cryo-freezing method for vessels. Investigated parameters are the blood mass flow rate, the diameter of vessel, the number of vessel, and the location of tumorous tissue. Study is carried out for nine different blood mass flow rates varying from 10 g/min to 1200 g/ min. Tissues without blood vessel, with single, double and branched vessels are used for the experimental study. Vessels with inner diameter of 2.4, 3.2 and 4.0 mm are used. Liver of beef is employed as a tissue. Refrigerant is the nitrogen protoxide gas. Results show that the number of vessel, the diameter of vessel, the location of tumorous tissue, and the blood mass flow rate affect the freezing region size. Freezing region size decreases with increasing in diameter of vessel, number of vessel and blood mass flow rate. The large blood vessel located near the tumorous tissue affects the freezing time to destroy the tumor. The desired freezing region obtained in tumorous tissue with vessel develops later than the tumorous tissue without vessel. Results indicate that a tumorous tissue about 23 mm may be destroyed in a short time using cryo-freezing method when nitrogen protoxide gas is used as refrigerant gas.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bio-heat transfer in cancer treatment using cryo-freezing method

Kizilirmak

Turgut

2021

Journal of Thermal Engineering

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“…Santabrata Chakravarty et al [15] have investigated the dynamic response of heat and mass transfer to blood streaming through the arteries under stenotic conditions, while they have not considered the vessel bifurcation. Wang et al [16] have found that fractal vascular trees have an important effect on tissue temperature and intracellular ice formation during the combined cryosurgery and hyperthermia for cancer therapy. In addition, Zheng et al [17] have studied the thermal effects of bifurcation on the iceball morphology during cryosurgery.…”

Section: Introductionmentioning

confidence: 99%

A Computational Study on the Effect of Bifurcation Lesions with Different Structures on Blood Velocity and Temperature

Wan¹,

Zhang²,

He³

2021

Fluid Dynamics &Amp; Materials Processing

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Treating coronary bifurcation stenosis is still a challenging task. Existing procedures still display a relatively small rate of success. This paper aims to investigate numerically the effect of bifurcation lesions with different structures on the dynamics of blood flow and related temperature. The problem geometry is parametrically varied by changing the bifurcation angle and radius. A finite volume method is used to simulate the three-dimensional flow. The effects induced by the structure of the stenosis, the artery bifurcation angle and radius, and the inlet velocity of blood are discussed in terms of flow pattern, pressure distribution, and shear stress at the blood wall. The heat transfer from the solid tissue is also determined for different stenosis configurations. The present study has been conducted with the explicit intention to generate useful data for the development of methods curing the vascular stenosis with thermal ablation.

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“…During the cryopreservation for heat transport modelling, the Fourier equation is used [12,23,24,28,29]. The heat transfer in cryopreserving organisms or during a cryosurgery can be also described by the following models: the Pennes parabolic equation (1948) [32][33][34][35], the Cattaneo-Vernotte hyperbolic model (1958) [36][37][38][39], and the dual-phase lag model [40][41][42]. The heat proceeding during cryopreservation should be supplemented by parameters related to the phase-change phenomena [33][34][35]38,39,[41][42][43].…”

Section: Introductionmentioning

confidence: 99%

“…To model the mass transfer phenomenon on a macroscale, Fick's second law is used, which determines the local concentration over time caused by diffusion [12,25,[28][29][30][31]45]. Sometimes, Fick's second law is complemented by a velocity vector, which is defined by, e.g., the Navier-Stokes equation [11,17,34,46].…”

Section: Introductionmentioning

confidence: 99%

Numerical Modeling of Heat and Mass Transfer during Cryopreservation Using Interval Analysis

Skorupa

Piasecka-Belkhayat

2020

Applied Sciences

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In the paper, the numerical analysis of heat and mass transfer proceeding in an axially symmetrical articular cartilage sample subjected to the cryopreservation process is presented. In particular, a two-dimensional (axially symmetrical) model with imprecisely defined parameters is considered. The base of the heat transfer model is given by the interval Fourier equation and supplemented by initial boundary conditions. The phenomenon of cryoprotectant transport (Me2SO) through the extracellular matrix is described by the interval mass transfer equation. The liquidus-tracking (LT) method is used to control the temperature, which avoids the formation of ice regardless of the cooling and warming rates. In the LT process, the temperature decreases/increases gradually during addition/removal of the cryoprotectant, and the articular cartilage remains on or above the liquidus line so that no ice forms, independent of the cooling/warming rate. The discussed problem is solved using the interval finite difference method with the rules of directed interval arithmetic. Examples of numerical computations are presented in the final part of the paper. The obtained results of the numerical simulation are compared with the experimental results, realized for deterministically defined parameters.

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Three-dimensional numerical simulation of the effects of fractal vascular trees on tissue temperature and intracelluar ice formation during combined cancer therapy of cryosurgery and hyperthermia

Cited by 31 publications

References 41 publications

Bio-heat transfer in cancer treatment using cryo-freezing method

Bio-heat transfer in cancer treatment using cryo-freezing method

A Computational Study on the Effect of Bifurcation Lesions with Different Structures on Blood Velocity and Temperature

Numerical Modeling of Heat and Mass Transfer during Cryopreservation Using Interval Analysis

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