Three-dimensional myocardial activation imaging in a rabbit model

Liu, Chenguang; Zhang, Xin; Li, Zhong‐Ming; Pogwizd, Steven M.; He, Bin

doi:10.1109/tbme.2006.873701

Cited by 5 publications

References 30 publications

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Noninvasive estimation of three-dimensional cardiac electrical activities from body surface potential maps

Liu

Skadsberg

Ahlberg

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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A noninvasive three-dimensional (3D) cardiac electrical imaging (3DCEI) approach, which can estimate the location of the initiation site (IS) of activation and the resultant 3D activation sequence (AS) from body surface potential maps (BSPMs), was validated in an intact large mammalian model (swine) during acute ventricular pacing. Body surface potential mapping and intracavitary noncontact mapping (NCM) were performed simultaneously during pacing from both right ventricular (RV) sites (intramural) and left ventricular (LV) sites (endocardial). Subsequent 3DCEI analyses were performed on the measured BSPMs. In total, 5 RV and 5 LV sites from control and heart failure animals were paced. The averaged localization error of the RV and LV sites were 7.0+/-1.1 mm and 6.6+/-1.9 mm, respectively. The endocardial ASs as a subset of the estimated 3D ASs by 3DCEI were consistent with those reconstructed from the NCM system. The present experimental results demonstrate that the noninvasive 3DCEI approach can localize the initiation site and estimate cardiac activation sequence with good accuracy in an in vivo setting, under control, paced and/or diseased conditions.

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Noninvasive estimation of three-dimensional cardiac electrical activities from body surface potential maps

Liu

Skadsberg

Ahlberg

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Noninvasive Three-Dimensional Cardiac Activation Imaging From Body Surface Potential Maps: A Computational and Experimental Study on a Rabbit Model

Han

Zhang

et al. 2008

IEEE Trans. Med. Imaging

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Three-dimensional (3-D) cardiac activation imaging (3-DCAI) is a recently developed technique that aims at imaging the activation sequence throughout the 3-D volume of myocardium. 3-DCAI entails the modeling and estimation of the cardiac equivalent current density (ECD) distribution from which the local activation time within myocardium is determined as the time point with the peak amplitude of local ECD estimates. In this paper, we report, for the first time, an experimental study of the performance and applicability of 3-DCAI as judged by measured 3-D cardiac activation sequence using 3-D intra-cardiac mapping, in a group of 4 healthy rabbits during ventricular pacing. During the experiments, the body surface potentials and the intramural bipolar electrical recordings were simultaneously measured in a closed-chest condition to allow for a rigorous evaluation of the noninvasive 3-DCAI algorithm using the intra-cardiac mapping. The ventricular activation sequence non-invasively imaged from the body surface measurements by using 3-DCAI was generally in agreement with that obtained from the invasive intra-cardiac recordings. The overall difference between them, quantified as the root mean square (RMS) error, was 7.42±0.61 ms, and the normalized difference, quantified as the relative error (RE), was 0.24±0.03. The distance from the reconstructed site of initial activation to the actual pacing site, defined as the localization error (LE), was 5.47±1.57 mm. In addition, computer simulations were conducted to provide additional assessment of the performance of the 3-DCAI algorithm using a realistic-geometry rabbit heart-torso model. Averaged over 9 pacing sites, the RE and LE were 0.20±0.07 and 4.56±1.12 mm, respectively, for single-pacing, when 20 μV Gaussian white noise was added to the body surface potentials at 53 body surface locations. Averaged over 8 pairs of dual pacing, the RE was 0.25±0.06 for 20 μV additive noise. The present results obtained through both in vivo experimentation and computer simulation suggest that 3-DCAI can non-invasively capture important features of ventricular excitation (e.g. the activation origin and the activation sequence), and has the potential of becoming a useful imaging tool aiding cardiovascular research and clinical diagnosis and management of cardiac diseases.

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Temporal Sparse Promoting Three Dimensional Imaging of Cardiac Activation

Zhou

2015

IEEE Trans. Med. Imaging

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A new Cardiac Electrical Sparse Imaging (CESI) technique is proposed to image cardiac activation throughout the three-dimensional myocardium from body surface electrocardiogram (ECG) with the aid of individualized heart-torso geometry. The sparse property of cardiac electrical activity in the time domain is utilized in the temporal sparse promoting inverse solution, one formulated to achieve higher spatial-temporal resolution, stronger robustness and thus enhanced capability in imaging cardiac electrical activity. Computer simulations were carried out to evaluate the performance of this imaging method under various circumstances. A total of 12 single site pacing and 7 dual sites pacing simulations with artificial and the hospital recorded sensor noise were used to evaluate the accuracy and stability of the proposed method. Simulations with modeling error on heart-torso geometry and electrode-torso registration were also performed to evaluate the robustness of the technique. In addition to the computer simulations, the CESI algorithm was further evaluated using experimental data in an animal model where the noninvasively imaged activation sequences were compared with those measured with simultaneous intracardiac mapping. All of the CESI results were compared with conventional weighted minimum norm solutions. The present results show that CESI can image with better accuracy, stability and stronger robustness in both simulated and experimental circumstances. In sum, we have proposed a novel method for cardiac activation imaging, and our results suggest that the CESI has enhanced performance, and offers the potential to image the cardiac activation and to assist in the clinical management of ventricular arrhythmias.

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Three-dimensional myocardial activation imaging in a rabbit model

Cited by 5 publications

References 30 publications

Noninvasive estimation of three-dimensional cardiac electrical activities from body surface potential maps

Noninvasive estimation of three-dimensional cardiac electrical activities from body surface potential maps

Noninvasive Three-Dimensional Cardiac Activation Imaging From Body Surface Potential Maps: A Computational and Experimental Study on a Rabbit Model

Temporal Sparse Promoting Three Dimensional Imaging of Cardiac Activation

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