Three-dimensional models of the membranous vestibular labyrinth in the guinea pig inner ear

Wu, Caiqin; Wang, Keqiang; Yang, Lin; Dai, Peidong

doi:10.1109/bmei.2011.6098245

Cited by 2 publications

(14 citation statements)

References 8 publications

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“…Further, our results, together with those of David et al. (), show that PTA staining performs as well as osmium tetroxide staining [used by Wu & Wang (), Uzun et al. () and Johnson Chacko et al.…”

Section: Discussionsupporting

confidence: 86%

“…; Rabbitt et al. ; Wu & Wang, ). Next to the higher spatial coherence of the X‐ray beam, allowing to benefit from strong phase‐contrast effects in X‐ray images, a further advantage of synchrotron X‐ray μCT set‐ups over conventional μCT scanners is the shorter scanning time due to the higher photon flux.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the clinical and biological relevance of this organ, its study remains difficult because of the embedment in dense skull bone (Zachary & Mc Gavin, ), the thinness of the membranes (Curthoys et al. ; Wu & Wang, ), and the limited difference in X‐ray density between the membranes and the surrounding liquid (Rabbitt et al. ; Ekdale, ).…”

Section: Discussionmentioning

confidence: 99%

“…; Rabbitt et al. ; Wu & Wang, ). These membranous walls constitute three semicircular ducts that are filled with endolymph fluid (together called the ‘membranous labyrinth’; Rabbitt et al.…”

Section: Introductionmentioning

confidence: 99%

“…Only a couple of authors have successfully visualised the membranous labyrinth yet (Uzun et al. ; Wu & Wang, ; David et al. ; Johnson Chacko et al.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced contrast in X‐ray microtomographic images of the membranous labyrinth using different X‐ray sources and scanning modes

Goyens

Vasilopoulou‐Kampitsi

Claes

et al. 2018

Journal of Anatomy

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The vestibular system, located in the inner ear, plays a crucial role in balance and gaze stabilisation by sensing head movements. The interconnected tubes with membranous walls of the vestibular system are located in the skull bone (the ‘membranous labyrinth’). Unfortunately, these membranes are very hard to visualise using three‐dimensional (3D) X‐ray imaging techniques. This difficulty arises due to the embedment of the membranes in the dense skull bone, the thinness of the membranes, and the small difference in X‐ray absorption between the membranes and the surrounding fluid. In this study, we compared the visualisation of very small specimens (lizard heads with vestibular systems smaller than 3 mm) by X‐ray computed micro‐tomography (μCT) based on synchrotron radiation and conventional sources. A visualisation protocol using conventional X‐ray μCT would be very useful thanks to the ease of access and lower cost. Careful optimisation of the acquisition parameters enables detection of the membranes by using μCT scanners based on conventional microfocus sources, but in some cases a low contrast‐to‐noise ratio (CNR) prevents fast and reliable segmentation of the membranes. Synchrotron radiation μCT proved to be preferable for the visualisation of the small samples with very thin membranes, because of their high demands for spatial and contrast resolution. The best contrast was obtained by using synchrotron radiation μCT working in phase‐contrast mode, leading to up to twice as high CNRs than the best conventional μCT results. The CNR of the synchrotron radiation μCT scans was sufficiently high enough to enable the construction of a 3D model by the means of semi‐automatic segmentation of the membranous labyrinth. Membrane thickness was found to range between 2.7 and 36.3 μm. Hence, the minimal membrane thickness was found to be much smaller than described previously in the literature (between 10 and 50 μm).

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Only a couple of authors have successfully visualised the membranous labyrinth yet (Uzun et al. ; Wu & Wang, ; David et al. ; Johnson Chacko et al.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enhanced contrast in X‐ray microtomographic images of the membranous labyrinth using different X‐ray sources and scanning modes

Goyens

Vasilopoulou‐Kampitsi

Claes

et al. 2018

Journal of Anatomy

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3D finite element model of posterior membranous labyrinth from in vivo MRI of human temporal bone, including sensory zones

Hv¹,

Lamy²,

Baumgärtner³

et al. 2019

J Transl Sci

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Objective: The aim of this work is to create a three-dimensional (3D) finite element model (FEM) of the human posterior membranous labyrinth, based on in vivo inner ear magnetic resonance imaging (MRI). Study design and setting:We used T2 weighted gradient-echo 3T MRI of a human inner ear. Images were acquired in vivo, from a patient presenting a vestibular schwannoma with a preserved labyrinthine geometry. Indeed, in this context, the elevation of the perilymphatic protides level secondary to the obstructive vestibular schwannoma enables a differentiation between the endolymph (which remains hyperintense on T2 weighted images) and the perilymph (hypointense on T2 weighted gradient echo images).Results: A 3D reconstruction of the posterior membranous labyrinth was performed through manual segmentation of the endolymphatic and sensory spaces. A mesh of the labyrinth was realized, first of its outer surface and then of its interior volume. The different structures of the labyrinth are included through a compartmentalization of the mesh. Sensory zones are precisely defined, based on a radio-histological correlation study. The resulting mesh of the model included 124,701 elements. Conclusion:Dimensions are in agreement with those in the literature, which is in favor of the validity of the model geometry. This model also has a pedagogical interest and can be useful for the clinical reflexion in cases of atypical benign paroxysmal positional vertigos (BPPV). It can also serve as a base for mechanical studies of vestibular physiology. Key points1. This 3D model is based on in vivo inner ear imaging.2. It is a FEM of human posterior membranous labyrinth.3. This model includes all the sensory zones of the posterior membranous labyrinth.

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Three-dimensional models of the membranous vestibular labyrinth in the guinea pig inner ear

Cited by 2 publications

References 8 publications

Enhanced contrast in X‐ray microtomographic images of the membranous labyrinth using different X‐ray sources and scanning modes

Enhanced contrast in X‐ray microtomographic images of the membranous labyrinth using different X‐ray sources and scanning modes

3D finite element model of posterior membranous labyrinth from in vivo MRI of human temporal bone, including sensory zones

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