Three Dimensional Models of Endocrine Organs and Target Tissues Regulated by the Endocrine System
Edlira Luca,
Kathrin Zitzmann,
Stefan Bornstein
et al.
Abstract:Immortalized cell lines originating from tumors and cultured in monolayers in vitro display consistent behavior and response, and generate reproducible results across laboratories. However, for certain endpoints, these cell lines behave quite differently from the original solid tumors. Thereby, the homogeneity of immortalized cell lines and two-dimensionality of monolayer cultures deters from the development of new therapies and translatability of results to the more complex situation in vivo. Organoids origin… Show more
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