Three-Dimensional Matrix-Induced Autologous Chondrocytes Implantation for Osteochondral Lesions of the Talus: Midterm Results

Magnan, Bruno; Samaila, Elena Manuela; Bondi, Manuel; Vecchini, Eugenio; Micheloni, Gian Mario; Bartolozzi, Pietro

doi:10.1155/2012/942174

Cited by 59 publications

(46 citation statements)

References 65 publications

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“…The initial three patients in the series underwent second-look arthroscopy with tissue biopsy; subsequent histological examination revealed repair tissue similar to hyaline cartilage. Recently, Magnan et al evaluated thirty patients with a mean lesion size of 2.36 cm 2 who were treated with matrix-induced autologous chondrocyte implantation 76 . The mean AOFAS score improved from 36.9 points preoperatively to 83.9 points at a mean follow-up of forty-five months (range, eighteen to ninety-six months).…”

Section: Matrix-associated Techniquementioning

confidence: 99%

Operative Treatment of Osteochondral Lesions of the Talus

Murawski

Kennedy

2013

Journal of Bone and Joint Surgery

230

201

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➤ Osteochondral lesions of the talus are common injuries in recreational and professional athletes, with up to 50% of acute ankle sprains and fractures developing some form of chondral injury. Surgical treatment paradigms aim to restore the articular surface with a repair tissue similar to native cartilage and to provide long-term symptomatic relief.➤ Arthroscopic bone-marrow stimulation techniques, such as microfracture and drilling, perforate the subchondral plate with multiple openings to recruit mesenchymal stem cells from the underlying bone marrow to stimulate the differentiation of fibrocartilaginous repair tissue in the defect site. The ability of fibrocartilage to withstand mechanical loading and protect the subchondral bone over time is a concern.➤ Autologous osteochondral transplantation techniques replace the defect with a tubular unit of viable hyaline cartilage and bone from a donor site in the ipsilateral knee. In rare cases, a graft can also be harvested from the ipsilateral talus or contralateral knee. The limitations of donor site morbidity and the potential need for an osteotomy about the ankle should be considered. Some anterior or far posterior talar lesions can be accessed without arthrotomy or with a plafondplasty.➤ Osteochondral allograft transplantation allows an osteochondral lesion with a large surface area to be replaced with a single unit of viable articular cartilage and subchondral bone from a donor that is matched to size, shape, and surface curvature. The best available evidence suggests that this procedure should be limited to large-volume cystic lesions or salvage procedures.➤ Autologous chondrocyte implantation techniques require a two-stage procedure, the first for chondrocyte harvest and the second for implantation in a periosteum-covered or matrix-induced form after in vivo culture expansion. Theoretically, the transplantation of chondrocyte-like cells into the defect will result in hyaline-like repair tissue.

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Section: Matrix-associated Techniquementioning

confidence: 99%

Operative Treatment of Osteochondral Lesions of the Talus

Murawski

Kennedy

2013

Journal of Bone and Joint Surgery

230

201

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“…[45]. The mean AOFAS score improved from 36.9 points to 83.9 points at a mean follow-up of forty-five months.…”

Section: Second Generation Autologous Chondrocyte Implantationmentioning

confidence: 84%

Talar Osteochondral Defects

Dijk¹,

Kennedy²

2014

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Intra-articular ankle injuries to the talar body is one of the common cause of athletic disability that have been estimated to occur in approximately 6.5% of the ankle sprains and commonly affect the dome of the talus. Patients are commonly referred to the clinics with an acute injury to the ankle or with chronic ankle instability. This article describes the clinical presentation and imaging to diagnose of talar osteochondral defects. The treatment optionsare also reviewed to give consensus on optimal treatment of this condition.

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“…Hasil MRI setelah operasi menunjukkan lebih banyak jaringan tulang rawan yang normal bila dibandingkan dengan pasien yang mendapat terapi microfracture. 23…”

Section: Gambar 5 Autologous Chondrocyte Implantation (Aci) (A) Ostunclassified

Patofisiologi dan Tatalaksana Osteochondral Lesion of the Talus

Roychan

Desnantyo

2019

Medica Arteriana (Med-Art)

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ABSTRAKLatar Belakang: Penyakit Osteochondral Lesion of the Talus (OLT) adalah kelainan pada tulang talus di lapisan subchondral yang berupa lesi osteochondral pada talar dome dengan konsekuensi abnormalitas pada tulang rawan sendi talar. Review artikel bertujuan menjabarkan patofisiologi dan tatalaksana OLT. Metode: Review artikel menggunakan literatur terkini yang relevan dengan topik OLT. Hasil: Pasien biasanya datang berobat ke tenaga kesehatan dengan keluhan yang tidak spesifik dan dengan gejala seperti nyeri pada pergelangan kaki, bengkak serta berkurangnya berkurangnya ruang gerak (range of movement). Penegakan diagnosis bisa dilakukan dengan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang sederhana seperti foto X-ray maupun pemeriksaan penunjang canggih seperti CT-Scan dan MRI. Tatalaksana pada OLT tergantung dari tahapan lesi, kronisitasnya, dan keluhan simtomatis yang menyertainya. Pasien dengan keluhan simtomatis yang akut dan non-displaced sering diberikan terapi konservatif dengan imobilisasi. Lesi yang tidak berhasil atau tidak menunjukkan perbaikan keluhan setelah 3 sampai 6 bulan, serta lesi dengan displacement dapat direncanakan untuk terapi operatif. Ada beberapa macam tehnik operatif yang dapat dilakukan untuk menyembuhkan OLT. Teknik operatif ini dapat dikategorikan menjadi cartilage repair, cartilage regeneration dan cartilage replacement techniques. Kesimpulan: OLT adalah lesiosteocondral pada talar dome yang dapat diterapi dengan terapi konservatif dan operatif cartilage repair, cartilage regeneration dan cartilage replacement techniques.Kata kunci: osteochondral lesion of the talus, patofisiologi, tatalaksana. ABSTRACT Background: Osteochondral Lesion of the Talus (OLT) is an abnormality in the talus bone in the subchondral layer in the form of osteochondral lesions in the talar dome with consequent abnormalities in the talar joint cartilage.This review wasa aimed to explain the pathophisiology and OLT management. Method: The litheratur review used recent literature suitable with OLT topics.Results: Patients usually come to a health care provider with nonspecific complaints and with symptoms such as pain in the ankles, swelling and reduced range of movement. The diagnosis can be made with a history taking, physical examination and simple investigations such as X-rays and sophisticated investigations such as CT-Scan and MRI. The management of OLT depends on the stage of the lesion, its chronicity, and the accompanying symptomatic complaints. Patients with acute and non-displaced symptomatic complaints are often given conservative therapy with immobilization. Lesions that are unsuccessful or show no improvement in symptomatic complaints after 3 to 6 months and lesions with displacement can be planned for operative therapy. There are several types of operative techniques that can be done to cure OLT. These operative techniques can be categorized into cartilage repair, cartilage regeneration, and cartilage replacement techniques. Conclusion: OLT is osteocondral lesion at talar dome can ...

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Three-Dimensional Matrix-Induced Autologous Chondrocytes Implantation for Osteochondral Lesions of the Talus: Midterm Results

Cited by 59 publications

References 65 publications

Operative Treatment of Osteochondral Lesions of the Talus

Operative Treatment of Osteochondral Lesions of the Talus

Talar Osteochondral Defects

Patofisiologi dan Tatalaksana Osteochondral Lesion of the Talus

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