Three-Dimensional Magnetic Manipulation of Micro- and Nanostructures for Applications in Life Sciences

Schuerle, Simone; Erni, Sandro; Flink, M.; Kratochvil, Bradley E.; Nelson, Bradley J.

doi:10.1109/tmag.2012.2224693

Cited by 153 publications

(86 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The OctoMag system enables five DoF wireless magnetic control of a fully-untethered microrobot, including three DoF of translation (3T) and two DoF of rotation (2R). Similar to OctoMag, electromagnetic systems consisting of multiple independently-controlled electromagnets are widely used for magnetically-actuated microrobots, such as the MiniMag with eight electromagnets used by Schuerle et al [60], a system with six electromagnets developed by Pawashe et al [61], a system with eight electromagnets arranged in a different way used by Diller et al [62] and And et al [54] and a system with four electromagnets used by Khalil et al [42]. These kinds of electromagnetic systems enable motion control with a high DoF.…”

Section: Electromagnetic Actuation Systemsmentioning

confidence: 99%

Magnetic Actuation Based Motion Control for Microrobots: An Overview

et al. 2015

View full text Add to dashboard Cite

Untethered, controllable, mobile microrobots have been proposed for numerous applications, ranging from micro-manipulation, in vitro tasks (e.g., operation of microscale biological substances) to in vivo applications (e.g., targeted drug delivery; brachytherapy; hyperthermia, etc.), due to their small-scale dimensions and accessibility to tiny and complex environments. Researchers have used different magnetic actuation systems allowing custom-designed workspace and multiple degrees of freedom (DoF) to actuate microrobots with various motion control methods from open-loop pre-programmed control to closed-loop path-following control. This article provides an overview of the magnetic actuation systems and the magnetic actuation-based control methods for microrobots. An overall benchmark on the magnetic actuation system and control method is also discussed according to the applications of microrobots.

show abstract

Section: Electromagnetic Actuation Systemsmentioning

confidence: 99%

Magnetic Actuation Based Motion Control for Microrobots: An Overview

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The coils focus on a 10 mm Â 10 mm Â 10-mm workspace, which is located 20 mm from the center of each coil. [12,13] By passing a current through each coil, a magnetic field is generated within the workspace.…”

Section: Simulation and Experimentsmentioning

confidence: 99%

“…Yesin et al [11] steered an elliptical micron-sized robot, with applications within different bodily fluids, by using Helmholtz and Maxwell coils that generated a magnetic field gradient of 0.7 T=m and a magnetic field strength of 0.2 T. The same group later developed a customized magnetic actuation system, which utilized superimposed magnetic fields from a number of electromagnetic coils to generate gradients of more than 2 T=m. [12,13] This system was used to propel microrobots by using an open-loop control system. To enable automatic closed-loop motion control of magnetic agents, a position feedback system is required.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic Steering of a Magnetic Cylindrical Microrobot Using Optical Feedback Closed-Loop Control

Ghanbari

Chang

Nelson

et al. 2014

International Journal of Optomechatronics

Self Cite

View full text Add to dashboard Cite

Control of small magnetic machines in viscous fluids may enable new medical applications of microrobots. Small-scale viscous environments lead to low Reynolds numbers, and although the flow is linear and steady, the magnetic actuation introduces a dynamic response that is nonlinear. We account for these nonlinearities, and the uncertainties in the dynamic and magnetic properties of the microrobot, by using time-delay estimation. The microrobot consists of a cylindrical magnet, 1 mm long and 500 lm in diameter, and is tracked using a visual feedback system. The microrobot was placed in silicone oil with a dynamic viscosity of 1 Pa.s, and followed step inputs with rise times of 0.45 s, 0.51 s, and 1.77 s, and overshoots of 37.5%, 33.3%, and 34.4% in the x, y, and z directions, respectively. In silicone oil with a viscosity of 3 Pa.s, the rise times were 1.04 s, 0.72 s, and 2.19 s, and the overshoots were 47.8%, 48.5%, and 86.8%. This demonstrates that closed-loop control of the magnetic microrobot was better in the less viscous fluid.

show abstract

“…III. MAGNETIC MANIPULATION The microscaffolds were manipulated using a magnetic manipulator (Minimag; Aeon Scientific), and the magnetic fields were defined by the combination of the current through the eight coils inside the magnetic manipulator [9]. Microscaffolds have shape anisotropy that offers the orientation against external magnetic fields.…”

Section: Design and Fabricationmentioning

confidence: 99%

Fabric of magnetically actuated microstructure for targeted cell transportation

Kim

Qiu

Kim

et al. 2013

2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013)

Self Cite

View full text Add to dashboard Cite

Here, we present a method for fabrication of full three-dimensional porous microstructures (microscaffolds) using photocurable polymer. The structures were coated with nickel and titanium for magnetic manipulation and biocompatibility, respectively. Fabricated microstructures were controlled by external magnetic fields for remote actuation. Human embryonic kidney 293 cells were cultured in the microstructures to demonstrate their feasibility for cell transportation. The fabricated microstructures described here are suitable for targeted cell transportation platforms.

show abstract

Three-Dimensional Magnetic Manipulation of Micro- and Nanostructures for Applications in Life Sciences

Cited by 153 publications

References 26 publications

Magnetic Actuation Based Motion Control for Microrobots: An Overview

Magnetic Actuation Based Motion Control for Microrobots: An Overview

Electromagnetic Steering of a Magnetic Cylindrical Microrobot Using Optical Feedback Closed-Loop Control

Fabric of magnetically actuated microstructure for targeted cell transportation

Contact Info

Product

Resources

About