Three-dimensional localization spectroscopy of individual nuclear spins with sub-Angstrom resolution

Zopes, Jonathan; Cujia, K. S.; Sasaki, Kento; Boss, J. M.; Itoh, Kohei M.; Degen, Christian L.

doi:10.1038/s41467-018-07121-0

Cited by 44 publications

(40 citation statements)

References 43 publications

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“…The use of the single-NV quantum sensor significantly reduces the required volume of analyte for nuclear magnetic resonance (NMR), ultimately down to the single molecular level. Recent demonstrations toward this ambitious goal include detection of single protons, 17 spectroscopy of single proteins, 18 sub-hertz spectral resolution, [19][20][21][22][23] spectroscopy and tracking of single nuclear spins via weak measurements, 24,25 determination of the positions of single nuclear spins, [26][27][28][29][30] and so forth. Remarkably, many of them have been realized at room temperature.…”

Section: Introductionmentioning

confidence: 99%

Construction and operation of a tabletop system for nanoscale magnetometry with single nitrogen-vacancy centers in diamond

et al. 2020

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A single nitrogen-vacancy (NV) center in diamond is a prime candidate for a solid-state quantum magnetometer capable of detecting single nuclear spins with prospective application to nuclear magnetic resonance (NMR) at the nanoscale. Nonetheless, an NV magnetometer is still less accessible to many chemists and biologists, as its experimental setup and operational principle are starkly different from those of conventional NMR. Here, we design, construct, and operate a compact tabletop-sized system for quantum sensing with a single NV center, built primarily from commercially available optical components and electronics. We show that our setup can implement state-of-the-art quantum sensing protocols that enable the detection of single 13 C nuclear spins in diamond and the characterization of their interaction parameters, as well as the detection of a small ensemble of proton nuclear spins on the diamond surface. This article providing extensive discussions on the details of the setup and the experimental procedures, our system will be reproducible by those who have not worked on the NV centers previously.

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Section: Introductionmentioning

confidence: 99%

Construction and operation of a tabletop system for nanoscale magnetometry with single nitrogen-vacancy centers in diamond

et al. 2020

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“…While conventional NMR requires averaging over large ensembles, recent progress with single-spin quantum sensors [2][3][4][5][6][7][8][9] has created the prospect of magnetic imaging of individual molecules [10][11][12][13]. As an initial step towards this goal, isolated nuclear spins and spin pairs have been mapped [14][15][16][17][18][19][20][21]. However, large clusters of interacting spins -such as found in molecules -result in highly complex spectra.…”

mentioning

confidence: 99%

Atomic-scale imaging of a 27-nuclear-spin cluster using a quantum sensor

Abobeih¹,

Randall²,

Bradley³

et al. 2019

Nature

202

177

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Nuclear magnetic resonance (NMR) is a powerful method for determining the structure of molecules and proteins [1]. While conventional NMR requires averaging over large ensembles, recent progress with single-spin quantum sensors [2][3][4][5][6][7][8][9] has created the prospect of magnetic imaging of individual molecules [10][11][12][13]. As an initial step towards this goal, isolated nuclear spins and spin pairs have been mapped [14][15][16][17][18][19][20][21]. However, large clusters of interacting spins -such as found in molecules -result in highly complex spectra. Imaging these complex systems is an outstanding challenge due to the required high spectral resolution and efficient spatial reconstruction with sub-angstrom precision. Here we develop such atomic-scale imaging using a single nitrogen-vacancy (NV) centre as a quantum sensor, and demonstrate it on a model system of 27 coupled 13 C nuclear spins in a diamond. We present a new multidimensional spectroscopy method that isolates individual nuclearnuclear spin interactions with high spectral resolution (< 80 mHz) and high accuracy (2 mHz). We show that these interactions encode the composition and inter-connectivity of the cluster, and develop methods to extract the 3D structure of the cluster with sub-angstrom resolution. Our results demonstrate a key capability towards magnetic imaging of individual molecules and other complex spin systems [9][10][11][12][13].The nitrogen-vacancy (NV) centre in diamond has emerged as a powerful quantum sensor [2-13, 22, 23]. The NV electron spin provides long coherence times [5, 6,20] and high-contrast optical readout [5,24,25], enabling high sensitivity over a large range of temperatures [5, 6,20,25,26]. Pioneering experiments with near-surface NV centers have demonstrated spectroscopy of small ensembles of nuclear spins in nano-scale volumes [2, 3,[5][6][7][8], and electron-spin labelled proteins [4]. Furthermore, single nuclear spin sensitivity has been demonstrated and isolated individual nuclear spins and spin pairs have been mapped [14][15][16][17][18][19][20][21]. Together, these results have established the NV center as a promising platform * T.H.Taminiau@TUDelft.nl for magnetic imaging of complex spin systems and single molecules [10][11][12][13].In this work, we realise a key ability towards that goal: the 3D imaging of large nuclear-spin structures with atomic resolution. The main idea of our method is to obtain structural information by accessing the couplings between individual nuclear spins. The key open challenges are: (1) to realize high spectral resolution so that small couplings can be accessed, (2) to isolate such couplings from complex spectra, and (3) to transform the revealed connectivity into the 3D spatial structure with sub-angstrom precision.The basic elements of our experiment are illustrated in Fig. 1a. We consider a cluster of 13 C nuclear spins in the vicinity of a single NV centre in diamond at 4 K. This cluster provides a model system for the magnetic imaging of single molecules and spin ...

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“…[], Section IIC). By tilting the magnetic field angle, and 2D spectrum, we also resolve the position of the nuclear‐spin pair in the diamond lattice as shown in Figure 3b. Fermi contact effect is taken into consideration .…”

Section: Resultsmentioning

confidence: 99%

Structural Analysis of Nuclear Spin Clusters via 2D Nanoscale Nuclear Magnetic Resonance Spectroscopy

Yang

Kong

et al. 2020

Adv Quantum Tech

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2D nuclear magnetic resonance (NMR) is essential in molecular structure determination. The nitrogen vacancy (NV) center in diamond is proposed and developed as an outstanding quantum sensor to realize NMR in nanoscale. In this work, a scheme for 2D nanoscale NMR spectroscopy is developed based on quantum controls on an NV center. A proof‐of‐principle experiment on a target of two coupled 13C nuclear spins in diamond is carried out. A correlation spectroscopy (COSY) like sequence is used to acquire the data on time domain, which is then converted to frequency domain with the fast Fourier transform. With the 2D NMR spectrum, the structure and location of the set of nuclear spin are resolved. This work marks a fundamental step toward resolving the structure of a single molecule.

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Three-dimensional localization spectroscopy of individual nuclear spins with sub-Angstrom resolution

Cited by 44 publications

References 43 publications

Construction and operation of a tabletop system for nanoscale magnetometry with single nitrogen-vacancy centers in diamond

Construction and operation of a tabletop system for nanoscale magnetometry with single nitrogen-vacancy centers in diamond

Atomic-scale imaging of a 27-nuclear-spin cluster using a quantum sensor

Structural Analysis of Nuclear Spin Clusters via 2D Nanoscale Nuclear Magnetic Resonance Spectroscopy

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