Three-dimensional Imaging of the Inner Ear by Volume-Rendered Reconstructions of Magnetic Resonance Data

Klingebiel, Randolf; Thieme, Nadine; Kivelitz, Dietmar; Enzweiler, Christian N.H.; Werbs, M.; Lehmann, Rüdiger

doi:10.1001/archotol.128.5.549

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…There have been many CT or MRI studies of the bony labyrinth whose primary focus is illustrative (e.g., Harada et al 1990;Kassemi et al 2005;Klingebiel et al 2002); in contrast, here, we derive a mathematical model from optimization formulations directly verified with micro-CT of cadaveric temporal bone (Uzun et al 2007).…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model of Human Semicircular Canal Geometry: A New Basis for Interpreting Vestibular Physiology

Bradshaw

Curthoys

Todd

et al. 2009

JARO

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We report a precise, simple, and accessible method of mathematically measuring and modeling the threedimensional (3D) geometry of semicircular canals (SCCs) in living humans. Knowledge of this geometry helps understand the development and physiology of SCC stimulation. We developed a framework of robust techniques that automatically and accurately reconstruct SCC geometry from computed tomography (CT) images and are directly validated using micro-CT as ground truth. This framework measures the 3D centroid paths of the bony SCCs allowing direct comparison and analysis between ears within and between subjects. An average set of SCC morphology is calculated from 34 human ears, within which other geometrical attributes such as nonplanarity, radius of curvature, and inter-SCC angle are examined, with a focus on physiological implications. These measurements have also been used to critically evaluate plane fitting techniques that reconcile many of the discrepancies in current SCC plane studies. Finally, we mathematically model SCC geometry using Fourier series equations. This work has the potential to reinterpret physiology and pathophysiology in terms of real individual 3D morphology.

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Section: Introductionmentioning

confidence: 99%

A Mathematical Model of Human Semicircular Canal Geometry: A New Basis for Interpreting Vestibular Physiology

Bradshaw

Curthoys

Todd

et al. 2009

JARO

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“…9 The feasibility of high-resolution MRI ͑HR-MRI͒ as a diagnostic tool for SNHL, tinnitus, and vertigo has been demonstrated. 10 Functional MRI was also used to study central auditory processing in cochlear implant recipients. 11 Nevertheless, at present neither CT nor MRI has sufficient spatial resolution ͑on the order of a few millimeters͒ to visualize the cochlear microanatomy.…”

Section: Introductionmentioning

confidence: 99%

Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography

et al. 2010

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There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea for clinical as well as fundamental studies. In this study, we explored, the feasibility of spectral domain optical coherence tomography (SD-OCT) for 3-D in vivo imaging of the cochlea in mice. The SD-OCT system employed in this study used a broadband light source centered at 1300 nm, and the imaging speed of the system was 47,000 A-scans per second using the InGaAs camera. The system was capable of providing fully processed, high-resolution B-scan images [512 (axial) x 128 (lateral) pixels] at 280 frames per sec. The 3-D imaging acquisition time for a whole cochlea was approximately 0.45 sec. The traditional SD-OCT structural imaging algorithm was used to reconstruct 3-D cochlear morphology. We demonstrated that SD-OCT can be successfully used for in vivo imaging of important morphological features within the mouse cochlea, such as the otic capsule and structures within, including Reissner's membrane, the basilar membrane, tectorial membrane, organ of Corti, and modiolus of the apical and middle turns.

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“…The capability of most modern clinical high-resolution computed tomography (CT) [10,11] or magnetic resonance imaging [12][13][14] is still quite limited for the three-dimensional reconstruction of membranous compartments. Although micro CT [15,16] and magnetic resonance microscopy (MRM) [17][18][19][20][21] were used for the three-dimensional reconstruction of the mammalian inner ear, their spatial resolution is too limited for any precise three-dimensional reconstruction of the tiny structures of the human inner ear.…”

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confidence: 99%

An Approach for Precise Three-Dimensional Modeling of the Human Inner Ear

Zhang

Wang

2006

ORL

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For further morphological and physiological research, it is vital to establish precise three-dimensional models of the whole inner ear including the details of the membranous components. With the system of a projector and a high-resolution digital camera, 2 complete serial unstained celloidin sections of fresh human temporal bones were digitized as high-resolution images which were then sorted, calibrated, aligned and segmented using the 3D-Doctor software. Finally, 2 precise three-dimensional models of the inner ear were generated by simple surface rendering. The contours of tiny structures such as the crista ampullaris, the macula utriculi and the macula sacculi could be observed clearly. Our study suggests that it is technically feasible to employ complete serial unstained celloidin sections for precise three-dimensional reconstruction and that this helps reduce errors and laboratory workload. Moreover, the use of a high-resolution digital camera and the autoalignment function of 3D-Doctor further increase the accuracy of the models.

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Three-dimensional Imaging of the Inner Ear by Volume-Rendered Reconstructions of Magnetic Resonance Data

Abstract: Volume rendering is the postprocessing technique of choice for 3-dimensional inner ear visualization, performing better than maximum-intensity projections with respect to various parameters.

Cited by 12 publications

References 15 publications

A Mathematical Model of Human Semicircular Canal Geometry: A New Basis for Interpreting Vestibular Physiology

A Mathematical Model of Human Semicircular Canal Geometry: A New Basis for Interpreting Vestibular Physiology

Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography

An Approach for Precise Three-Dimensional Modeling of the Human Inner Ear

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