To date, environmental and healthcare problems have become the most important and challenging issues globally. Demands for fast and low-cost sensing methods and devices for environment monitoring [1], point-of-care diagnosis [2], and food and water safety control [3] are growing rapidly over the years, especially in the underdeveloped areas. Thanks to the advancement of nanotechnology in the past decade, nanomaterials, especially when combined with modern optical sensing techniques, provide us with many new tools, such as surface-enhanced Raman spectroscopy [4], surface plasmon resonance [5], photonic crystal [6], and optofluidics [7], for the sensing applications not accessible by traditional sensing techniques. In the recent decade the research in this field has become flourishing. Figure 1 shows the number of publications in this field according to Thomson Reuters' Web of Science. From Figure 1 we can see that the number of scientific publications has been sky-rocketing. In order to cover the recent progress and ongoing work in this booming field, this timely special issue is dedicated to synthesis, fabrication, characterization, and numerical modeling of nanomaterials and nanostructures with potential applications in biomedical researches [8], environment monitoring [9,10], explosives trace detection [11], and so on.This special issue contains 6 articles which cover the academic fields of environmental science, materials science, life science, nanotechnology, optics, physics, and chemistry.In the research article "Investigation of the Validity of the Universal Scaling Law on Linear Chains of Silver Nanoparticles," M. Alsawafta et al. examined (the generalization of) the universal scaling behavior for spherical silver nanoparticles arranged in finite linear chains (eight nanoparticles) and embedded in different host media. The results of simulation show that the plasmon ruler equation can be successfully extended to represent the fractional plasmon shift of many interacting nanoparticles. The decay length and the mount of the fractional shift of the silver linear chains strongly depend on the polarization state of the incident polarization. The LM exhibits a significant shift of the plasmon resonance (indicated by the value of ) as compared to that of the TM. This can be explained by the fact that the enhancement of the local field under parallel polarization is more pronounced. On the other hand, the decay of the TM shows a strong dependency on the dielectric function of the surrounding medium. It decays twice faster than the LM, as the host medium becomes denser.In the research article "Focused Ion Beam Assisted Interface Detection for Fabricating Functional Plasmonic Nanostructures," H. Wang et al. proposed the FIB-assisted interface detection and successfully carried out it using the sampleabsorbed current as the detection signal, and the patterning depth control for the plasmonic structure fabrication was achieved through controlling machining time or ion dose using the EPM. Material-dependent currents w...