Three-dimensional histology for dermatofibrosarcoma protuberans: Case series and surgical technique

Irarrazaval, Isabel; Redondo, Pedro

doi:10.1016/j.jaad.2012.03.034

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…In this study, 7 baseline patients' characteristics, recurrence and clinical outcomes were not significantly different between MMS techniques. Comparing both techniques, in terms of performance and implementation in daily practice, frozen MMS (or direct/fresh Mohs) has the main advantage of reducing surgical times as it implies immediate microscopic examination of surgical margins 22,23 and completion of surgery with definite wound closure at the same surgical process 24‐26 …”

Section: Resultsmentioning

confidence: 99%

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Nieto‐Benito

Ciudad-Blanco

Sanmartín-Jiménez

et al. 2021

Experimental Dermatology

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Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined. In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence. Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities. Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person‐years (95% IC = 0.36–2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence. Median follow‐up time was 28.6 months with 414 patient‐years of follow‐up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.

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Section: Resultsmentioning

confidence: 99%

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Nieto‐Benito

Ciudad-Blanco

Sanmartín-Jiménez

et al. 2021

Experimental Dermatology

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“…En la literatura consultada se encuentran reportadas tres series de casos de pacientes con DFSP [12][13][14], sin embargo, una de ellas se enfoca en la técnica quirúrgica evaluada (13) y otra en una diferenciación de esta neoplasia conocida como DFSP con diferenciación fibrosarcomatosa (DFSP-FS) [14].…”

Section: Discussionunclassified

Estudio Observacional: Dermatofibrosarcoma Protuberans, Serie de casos.

et al. 2019

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Introducción: El dermatofibrosarcoma protuberans (DFSP), es uno de los tumores cutáneos menos frecuentes, se clasifica dentro de los sarcomas fibrohistociticos y está caracterizado por un crecimiento lento y progresivo. Métodos: Se realizó una serie de casos retrospectiva de los pacientes con DFSP atendidos en el Centro de la Piel (CEPI) entre 2010 y 2019, se tomó en cuenta la información demográfica, características clínicas, tratamiento y su evolución. Resultados: Seis pacientes fueron diagnosticados y tratados por DFSP en el período evaluado, existió un predominio de mujeres (4 mujeres, 2 hombres) con una media de edad de 58.2 (DE =19,6), tres de ellos presentaron lesiones en forma de placa indurada y los restantes presentaron nódulo único, la localización de las lesiones fueron en hombro, cuello e hipogastrio. El tratamiento más utilizado fue la escisión amplia, ninguno de los pacientes presentó recidivas al primer y quinto año del seguimiento. Conclusión: Es necesario el reconocimiento de las características clínicas típicas de DFSP ya que podría pasar como una tumoración benigna de piel, por lo cual se debe apoyar con el estudio histopatológico frente a la sospecha de este tipo de lesión.

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“…NCCN recommend CCPDMA or Mohs surgery to treat DFSP. Usually, the complete surgical resection with margins of 2–4 cm is performed (Irarrazaval & Redondo, ). In fact, most of dermatologic or plastic surgeries of DFSP follow 3 cm resection margin criteria (Buck et al, ; Erdem et al, ).…”

Section: Discussionmentioning

confidence: 99%

Improving precision of resection by pre-surgery inspections with contrast-enhanced ultrasound for dermatofibrosarcoma protuberans

Sun

Yang

et al. 2016

Dermatologic Therapy

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Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon malignant soft tissue tumor. Although metastasis is rare, it has significant topo-aggressive characteristics with a high recurrence rate. The common treatment of DFSP is surgical resection. This study reported a case of a 22 years old woman who presented DFSP with single irregular red plaque in the right occipital area. The plaque is about 2 cm × 2 cm in diameter with an irregular and unclear border. In order to minimize the range of resection area, the contrast-enhanced ultrasound (CEUS) was used to precisely identify the tumor affected area before the surgery treatment. The result shows that CEUS depicted clear structure of the tumor, which successfully helped surgeons to reduce the resection range from 3 cm to 2 cm in diameter. The tumor has been completely removed by one surgery operation only, and no relapse was found up to now. Pre-surgery CEUS inspection of DFSP could be an effective and economical method to minimize the patient's hurts in the surgical treatment of DFSP.

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Three-dimensional histology for dermatofibrosarcoma protuberans: Case series and surgical technique

Cited by 13 publications

References 23 publications

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature

Estudio Observacional: Dermatofibrosarcoma Protuberans, Serie de casos.

Improving precision of resection by pre-surgery inspections with contrast-enhanced ultrasound for dermatofibrosarcoma protuberans

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