Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution.

Purpose: To demonstrate in vivo magnetic resonance spectroscopic imaging (MRSI) of the human prostate at 4.0T using a transmit/receive endorectal coil and a pulse sequence designed specifically for this application. Materials and Methods:A solid, reusable endorectal probe was designed for both radiofrequency transmission and reception. Finite difference time domain (FDTD) simulations were performed to characterize the coil's electric field distribution, and temperature measurements were performed in a beef tissue phantom to determine the coil's safe operating limit. The localization by selective adiabatic refocusing (LASER) pulse sequence was implemented using six gradient modulated offset independent adiabatic (GOIA) pulses for very sharp, B 1 -insensitive voxel localization.Results: Based on the simulations and temperature measurements, the coil's safe operating limit was conservatively estimated to be 1.0W for 15 minutes. The transition width of the GOIA pulse selection profiles was only 6% of the bandwidth, compared with 22% for a specific absorption rate (SAR)-matched conventional adiabatic pulse. Using the coil and pulse sequence described here, MRSI data were successfully acquired from a patient with biopsyproven prostate cancer, with a nominal voxel size of 0.34 cc in a scan time of 15 minutes. Conclusion:This work demonstrates the safe and effective use of a transmit/receive endorectal coil for in vivo MRSI of the prostate.

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“…This is in agreement with previous studies that have shown the highest citrate/choline ratios in the peripheral zone (2,24).…”

Section: Discussionsupporting

confidence: 94%

“…MAGNETIC RESONANCE SPECTROSCOPIC IMAGING (MRSI) of the prostate yields high sensitivity and specificity in the localization of prostate cancers (1)(2)(3)(4). Cancer detection is achieved by mapping the relative concentrations of metabolic markers of disease-citrate, choline, and creatine-throughout the prostate.…”

mentioning

confidence: 99%

High‐field MRSI of the prostate using a transmit/receive endorectal coil and gradient modulated adiabatic localization

Near

Romagnoli

Curtis

et al. 2009

Magnetic Resonance Imaging

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“…Many magnetic resonance spectroscopy (MRS) studies of choline metabolism have shown increased levels of total Cho (tCho) in cancers developing in different organs, such as brain, 1-5 prostate [6][7][8] and breast. [9][10][11][12][13] The increase of tCho in tumors has become a potentially important biomarker in cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Cudalbu

Comment

Kurdzesau

et al. 2010

Phys. Chem. Chem. Phys.

125

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The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo 13 C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized 15 N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 AE 16 s) and in vivo (126 AE 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized 15 N labeled choline in live animals.

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“…Moreover, owing to the overlap of spectral peaks, the composite metabolite ratio (choline + spermine + creatine)/citrate is usually measured from prostate spectra, using integration. There are only a few instances where absolute concentrations of citrate, creatine, and choline have been measured, using either integration or metabolite fitting 8, 9, 10, 11, 12…”

mentioning

confidence: 99%

TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

Basharat

Payne

Morgan

et al. 2015

Magnetic Resonance Imaging

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PurposeTo compare the depiction of metabolite signals in short and long echo time (TE) prostate cancer spectra at 3T, and to quantify their concentrations in tumors of different stage and grade, and tissues adjacent to tumor.Materials and MethodsFirst, single‐voxel magnetic resonance imaging (MRI) spectra were acquired from voxels consisting entirely of tumor, as defined on T 2‐weighted and diffusion‐weighted (DW)‐MRI and from a biopsy‐positive octant, at TEs of 32 msec and 100 msec in 26 prostate cancer patients. Then, in a separate cohort of 26 patients, single‐voxel TE = 32 msec MR spectroscopy (MRS) was performed over a partial‐tumor region and a matching, contralateral normal‐appearing region, defined similarly. Metabolite depiction was compared between TEs using Cramér‐Rao lower bounds (CRLB), and absolute metabolite concentrations were calculated from TE = 32 msec spectra referenced to unsuppressed water spectra.ResultsCitrate and spermine resonances in tumor were better depicted (had significantly lower CRLB) at TE = 32 msec, while the choline resonance was better depicted at TE = 100 msec. Citrate and spermine concentrations were significantly lower in patients of more advanced stage, significantly lower in Gleason grade 3+4 than 3+3 tumors, and significantly lower than expected from the tumor fraction in partial‐tumor voxels (by 14 mM and 4 mM, respectively, P < 0.05).ConclusionCitrate and spermine resonances are better depicted at short TE than long TE in tumors. Reduction in these concentrations is related to increasing tumor stage and grade in vivo, while reductions in the normal‐appearing tissues immediately adjacent to tumor likely reflect tumor field effects. J. Magn. Reson. Imaging 2015;42:1086–1093.

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Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution.

Abstract: These results suggest that a 3D MRSI examination added to a clinical MR imaging examination may help define the presence and spatial extent of prostate cancer.

Cited by 569 publications

References 0 publications

High‐field MRSI of the prostate using a transmit/receive endorectal coil and gradient modulated adiabatic localization

High‐field MRSI of the prostate using a transmit/receive endorectal coil and gradient modulated adiabatic localization

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

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Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.7-cm3) spatial resolution.

Abstract: These results suggest that a 3D MRSI examination added to a clinical MR imaging examination may help define the presence and spatial extent of prostate cancer.

Cited by 569 publications

References 0 publications

High‐field MRSI of the prostate using a transmit/receive endorectal coil and gradient modulated adiabatic localization

High‐field MRSI of the prostate using a transmit/receive endorectal coil and gradient modulated adiabatic localization

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

TE = 32 ms vs TE = 100 ms echo‐time 1H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues

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TE = 32 ms vs TE = 100 ms echo‐time ¹H‐magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues