Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts
Mehmet Nizamoglu,
Frederique Alleblas,
Taco Koster
et al.
Abstract:Idiopathic pulmonary fibrosis (IPF), for which effective treatments are limited, results in excessive and disorganized deposition of an aberrant extracellular matrix (ECM). An altered ECM microenvironment is postulated to contribute to disease perpetuation in a feed-forward manner through inducing profibrotic behavior by lung fibroblasts, the main producers and regulators of ECM. Here, we examined this hypothesis in a 3Din vitromodel system by growing primary human lung fibroblasts in ECM-derived hydrogels fro… Show more
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