Three-dimensional electrochemical DNA biosensor based on 3D graphene-Ag nanoparticles for sensitive detection of CYFRA21-1 in non-small cell lung cancer

Chen, Mei; Wang, Yuanyuan; Su, Huilan; Mao, Li; Jiang, Xinni; Zhang, Tao; Dai, Xiaozhen

doi:10.1016/j.snb.2017.09.111

Cited by 116 publications

(27 citation statements)

References 43 publications

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“…Some of the compounds detected electrochemically using graphene and graphene‐based materials as electrode material include dopamine, glucose, H 2 O 2 , haemoglobin, DNA, glycoproteins, cancer cells, adenosine triphosphate (ATP), angiogenin, K562 leukemia cancer cells, human epidermal growth factor receptor 2; electrochemical DNA biosensor is developed for quantitative detection of breast cancer 1 (BRCA1) gene, impedimetric immunosensor for the direct detection of bacterial toxin botulinum has been developed using gold nanoparticles/graphene–chitosan composite, staphylococcal enterotoxin B has been detected using Au–Gr–Cs‐modified glassy carbon electrode, Au nanoparticles (NPs) nanocomposite and polypyrene electrochemically reduced graphene oxide flm‐coated disposable screen‐printed carbon electrode based on the voltammetric immunosensing method for fast, sensitive, and selective detection of two mycotoxins, deoxynivalenol, and fumonisin B1 (FB1) in spiked corn samples . Another impedimetric immunosensor has been developed for the rapid detection of ochratoxin (OTA) in food samples by immobilizing both anti‐OTA antibody and amine‐terminated dendrimer on the graphene oxide sheets .…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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Graphene and its composite materials are very important in many disciplines of science and have been used enormously by researchers since their discovery in 2004. These are a new group of compounds, and are also wonderful model systems for quantum behavior studies. Their properties like exceptional conductivity, biocompatibility, surface area, mechanical strength, and thermal properties make them rising stars in the scientific community. Graphene and its composite compounds are utilized widely in different medical applications, for example, biosensing of biological compounds responsible for disease development, bioimaging of various cells, tissues, microorganisms, animal models, etc. In addition, they are used for enhancing and supporting the stem cell differentiation, i.e., regenerative medicine for regeneration studies of various human organs, tissue engineering in biology for the development of carrier materials, as well as in bone reformation. This review focuses on the modification procedure involved in the fabrication of graphene‐based biomaterials for various applications and recent developments in research related to graphene and graphene‐based materials in biosensing, optical sensing, gas sensing, drug, gene, protein delivery, tissue engineering, and bioimaging. In addition, the potential toxicological effects of graphene‐based biomaterials are discussed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Graphene and Graphene‐Based Materials in Biomedical Science

Swetha

Manisha

Prasad

2018

Part & Part Syst Charact

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“…Generally, 3D graphene can be achieved as 3D reduced graphene oxide (3D-rGO) from reducing 3D graphene oxide (3D-GO) or chemically integrating from 2D-rGO sheets via gelation technologies [37]. 3D-rGO shows superior bioelectrochemical performance due to its high specific surface area, unique morphology and structure, a large number of electroactive sites and acceleration of electron transfer [38,39].…”

Section: Introductionmentioning

confidence: 99%

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Xia

Chen

et al. 2020

Electroanalysis

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A label‐free DNA biosensor based on three‐dimensional reduced graphene oxide (3D‐rGO) and polyaniline (PANI) nanofibers modified glassy carbon electrode (GCE) was successfully developed for supersensitive detection of breast cancer BRCA1. The results demonstrated that 3D‐rGO and PANI nanofibers had synergic effects for reducing the charge transfer resistance (Rct), meaning a huge enhancement in electrochemical activity of 3D‐rGO‐PANI/GCE. Probe DNA could be immobilized on 3D‐rGO‐PANI/GCE for special and sensitive recognition of target DNA (1.0×10−15–1.0×10−7 M) with a theoretical LOD of 3.01×10−16 M (3S/m). Furthermore, this proposed nano‐biosensor could directly detect BRCA1 in real blood samples.

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“…Verma et al fabricated an electrochemical immunosensor with Au NPs-rGO as the transducer matrix for noninvasive detection of oral cancer biomarker interleukin-8 (Figure 4) [59]. Chen et al designed an electrochemical DNA biosensor based on Ag NPs-3D graphene foam for sensitively and specifically detecting the biomarker CYFRA21-1 DNA from a non-small cell in lung cancer [60]. Electrochemical Biosensing is an effective and fast strategy for early clinical diagnosis of cancer, which has been further confirmed by other similar works [61,62,63,64,65,66].…”

Section: Graphene Based Cancer Nanociagnosismentioning

confidence: 99%

Biomarkers-based Biosensing and Bioimaging with Graphene for Cancer Diagnosis

Tang

Xiong

et al. 2019

Nanomaterials

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At the onset of cancer, specific biomarkers get elevated or modified in body fluids or tissues. Early diagnosis of these biomarkers can greatly improve the survival rate or facilitate effective treatment with different modalities. Potential nanomaterial-based biosensing and bioimaging are the main techniques in nanodiagnostics because of their ultra-high selectivity and sensitivity. Emerging graphene, including two dimensional (2D) graphene films, three dimensional (3D) graphene architectures and graphene hybrids (GHs) nanostructures, are attracting increasing interests in the field of biosensing and bioimaging. Due to their remarkable optical, electronic, and thermal properties; chemical and mechanical stability; large surface area; and good biocompatibility, graphene-based nanomaterials are applicable alternatives as versatile platforms to detect biomarkers at the early stage of cancer. Moreover, currently, extensive applications of graphene-based biosensing and bioimaging has resulted in promising prospects in cancer diagnosis. We also hope this review will provide critical insights to inspire more exciting researches to address the current remaining problems in this field.

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Three-dimensional electrochemical DNA biosensor based on 3D graphene-Ag nanoparticles for sensitive detection of CYFRA21-1 in non-small cell lung cancer

Cited by 116 publications

References 43 publications

Graphene and Graphene‐Based Materials in Biomedical Science

Graphene and Graphene‐Based Materials in Biomedical Science

Employing Label‐free Electrochemical Biosensor Based on 3D‐Reduced Graphene Oxide and Polyaniline Nanofibers for Ultrasensitive Detection of Breast Cancer BRCA1 Biomarker

Biomarkers-based Biosensing and Bioimaging with Graphene for Cancer Diagnosis

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