Three-dimensional drivable optrode array for high-resolution neural stimulations and recordings in multiple brain regions

Wang, Minghao; Gu, Xiaowei; Ji, Bowen; Wang, Longchun; Guo, Zhejun; Wang, Xiaolin; Li, Chengyu; Liu, Jingquan

doi:10.1016/j.bios.2019.01.019

Cited by 11 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A drivable part which can lead the probe tip to break through the wrap and continue to function becomes a good choice. The drivable optoprobes are inspired by the micro-actuated structure of the electrodes [ 118 , 119 ], which can be customized according to the different optical components ( Figure 3 a,b) [ 97 , 116 ] or simpler 3D-printed molds [ 120 , 121 , 122 ]. The 3D-printed mold can also precisely control the adjustment step by twisting of the screw, shown in Figure 3 c, and the minimum step is as low as 320 μm [ 122 ].…”

Section: Optoprobesmentioning

confidence: 99%

A Review: Research Progress of Neural Probes for Brain Research and Brain–Computer Interface

2022

View full text Add to dashboard Cite

Neural probes, as an invasive physiological tool at the mesoscopic scale, can decipher the code of brain connections and communications from the cellular or even molecular level, and realize information fusion between the human body and external machines. In addition to traditional electrodes, two new types of neural probes have been developed in recent years: optoprobes based on optogenetics and magnetrodes that record neural magnetic signals. In this review, we give a comprehensive overview of these three kinds of neural probes. We firstly discuss the development of microelectrodes and strategies for their flexibility, which is mainly represented by the selection of flexible substrates and new electrode materials. Subsequently, the concept of optogenetics is introduced, followed by the review of several novel structures of optoprobes, which are divided into multifunctional optoprobes integrated with microfluidic channels, artifact-free optoprobes, three-dimensional drivable optoprobes, and flexible optoprobes. At last, we introduce the fundamental perspectives of magnetoresistive (MR) sensors and then review the research progress of magnetrodes based on it.

show abstract

Section: Optoprobesmentioning

confidence: 99%

A Review: Research Progress of Neural Probes for Brain Research and Brain–Computer Interface

2022

View full text Add to dashboard Cite

show abstract

“…For example, fMRI provides an excellent aid for the study of psychiatric disorders [ 3 , 4 ]. However, for dynamic observation of neuronal and synaptic activities at the single-cell level down to molecular scales, craniotomy experiments are frequently required for implantation of cortical and deep-brain electrodes or electrode arrays [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. For two-photon experiments and fluorescence measurements, cranial surgery is also performed in installation of many novel brain-computer-interfaces (BCIs) [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

A Hybrid Titanium-Softmaterial, High-Strength, Transparent Cranial Window for Transcranial Injection and Neuroimaging

et al. 2022

View full text Add to dashboard Cite

A transparent and penetrable cranial window is essential for neuroimaging, transcranial injection and comprehensive understanding of cortical functions. For these applications, cranial windows made from glass coverslip, polydimethylsiloxane (PDMS), polymethylmethacrylate, crystal and silicone hydrogel have offered remarkable convenience. However, there is a lack of high-strength, high-transparency, penetrable cranial window with clinical application potential. We engineer high-strength hybrid Titanium-PDMS (Ti-PDMS) cranial windows, which allow large transparent area for in vivo two-photon imaging, and provide a soft window for transcranial injection. Laser scanning and 3D printing techniques are used to match the hybrid cranial window to different skull morphology. A multi-cycle degassing pouring process ensures a good combination of PDMS and Ti frame. Ti-PDMS cranial windows have a high fracture strength matching human skull bone, excellent light transmittance up to 94.4%, and refractive index close to biological tissue. Ti-PDMS cranial windows show excellent bio-compatibility during 21-week implantation in mice. Dye injection shows that the PDMS window has a “self-sealing” to keep liquid from leaking out. Two-photon imaging for brain tissues could be achieved up to 450 µm in z-depth. As a novel brain-computer-interface, this Ti-PDMS device offers an alternative choice for in vivo drug delivery, optical experiments, ultrasonic treatment and electrophysiology recording.

show abstract

“…Meanwhile, the implantable BCI has expanded many functional features, including the modulation of neural activities by light, electrical and magnetic stimulation, and drug delivery via microfluidics to achieve local control or treatment [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Most of the existing BCI devices are rigid, such as the Utah electrode arrays, Michigan probes and Pt-Ir microwire electrodes [17,[32][33][34][35][36][37][38][39][40][41]. The Utah electrode array shows the characteristics of high density, compact layout and reliability, which can collect hundreds of neural signals synchronously.…”

Section: Introductionmentioning

confidence: 99%

Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Zhou

Wang

et al. 2021

Coatings

View full text Add to dashboard Cite

Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades. Due to the inevitable damage of brain tissue caused by traditional rigid devices, the thin film devices are developing rapidly and attracting considerable attention, with continuous progress in flexible materials and non-silicon micro/nano fabrication methods. Therefore, it is necessary to systematically summarize the recent development of implantable thin film devices for acquiring brain information. This brief review subdivides the flexible thin film devices into the following four categories: planar, open-mesh, probe, and micro-wire layouts. In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution. Special substrates and interconnects are also highlighted with varied materials and fabrication routines. In conclusion, a discussion of the remaining obstacles and directions for future research is provided.

show abstract

Three-dimensional drivable optrode array for high-resolution neural stimulations and recordings in multiple brain regions

Cited by 11 publications

References 46 publications

A Review: Research Progress of Neural Probes for Brain Research and Brain–Computer Interface

A Review: Research Progress of Neural Probes for Brain Research and Brain–Computer Interface

A Hybrid Titanium-Softmaterial, High-Strength, Transparent Cranial Window for Transcranial Injection and Neuroimaging

Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Contact Info

Product

Resources

About