Three‐dimensional delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix‐associated autologous chondrocyte transplantation at 3.0T: Preliminary results

Trattnig, Siegfried; Marlovits, Stefan; Gebetsroither, S.; Szomolányi, Pavol; Welsch, Goetz H.; Salomonowitz, Erich; Watanabe, Atsuya; Deimling, M.; Mamisch, Tallal C.

doi:10.1002/jmri.21091

Cited by 148 publications

(167 citation statements)

References 40 publications

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“…29 To obtain dGEMRIC indices (T1 GD values) using the indirect MRA, a dual-flip angle (FA) 3D gradient echo (GRE) sequence utilizing inline T1 measurement was performed: ( inversion recovery (IR) method for T1 mapping] has been previously validated for the hip in phantom and in vivo studies. 30,31 The complete MRI examination including Gd-DTPA 2À injection, 45 min of waiting prior to MRA ($30 min) and scans for T1 mapping ($10 min) took approximately 90 min.…”

Section: Mri Analysis With Dgemricmentioning

confidence: 99%

Delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in Femoacetabular impingement

Mamisch

Kain

Bittersohl

et al. 2011

Journal Orthopaedic Research

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Femoroacetabular impingement is a well-described pre-arthritic condition with two main types; cam and pincer. Studies using the open treatment for impingement have described patterns of articular cartilage wear specific to cam and pincer impingement. Assessing articular damage in the hip joint is an important component of treatment. Intravenous gadolidium allows radiologists to perform an indirect assessment of articular cartilage glycosaminoglycan (GAG) content by using a technique called dGEMRIC. Using this indirect assessment of articular cartilage, we compared the dGEMRIC indices in a group of six cam and seven pincer patients to a control group (n ¼ 12) of asymptomatic controls that had no plain MRI findings of osteoarthritis. The superior portion of the hip joint was divided into seven regions from 9 to 3 o'clock. These regions were then subdivided into peripheral and central regions. The cam and pincer groups both had statistically lower dGEMRIC values compared to the control group. The cam group demonstrated not only peripheral but also central involvement of the joint and this was concentrated in the anterior portion of the joint. The pincer group exhibited more global hip involvement with all areas of the hip averaging a dGEMRIC index 28% less than controls. With the use of dGEMRIC more specific patterns of cartilage wear can be elicited in patients with impingement, which may improve patient selection and help better understand the progression of osteoarthithis throughout the hip joint. ß

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Section: Mri Analysis With Dgemricmentioning

confidence: 99%

Delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in Femoacetabular impingement

Mamisch

Kain

Bittersohl

et al. 2011

Journal Orthopaedic Research

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“…dGEMRIC has been previously validated in in vitro (10,11) and in vivo studies. (5,12) Recently, fast T 1 mapping techniques have been investigated in phantom studies and in vivo studies (13) and include major advantages such as faster imaging time and also its ability of three-dimensional (3D) acquisition.…”

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confidence: 99%

Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

Bittersohl¹,

Hosalkar²,

Hughes³

et al. 2009

Magnetic Resonance in Med

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This study defines the feasibility of utilizing three-dimensional (3D) gradient-echo (GRE) MRI at 1.5T for T* 2 mapping to assess hip joint cartilage degenerative changes using standard morphological MR grading while comparing it to delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). MRI was obtained from 10 asymptomatic young adult volunteers and 33 patients with symptomatic femoroacetabular impingement (FAI). The protocol included T* 2 mapping without gadolinium-enhancement utilizing a 3D-GRE sequence with six echoes, and after gadolinium injection, routine hip sequences, and a dual-flipangle 3D-GRE sequence for dGEMRIC T 1 mapping. Cartilage was classified as normal, with mild changes, or with severe degenerative changes based on morphological MRI. T 1 and T* 2 findings were subsequently correlated. There were significant differences between volunteers and patients in normally-rated cartilage only for T 1 values. Both T 1 and T* 2 values decreased significantly with the various grades of cartilage damage. There was a statistically significant correlation between standard MRI and T* 2 (T 1 ) (P < 0.05). High intraclass correlation was noted for both T 1 and T* 2 . Correlation factor was 0.860 to 0.954 (T* 2 -T 1 intraobserver) and 0.826 to 0.867 (T* 2 -T 1 interobserver). It is feasible to gather further information about cartilage status within the hip joint using GRE T* 2 mapping at 1.5T. Magn Reson Med 62:896 -901, 2009.

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“…4,5 To obtain a better insight into the ultrastructural composition of the cartilage repair tissue, biochemical MRI techniques have shown promising results in recent studies. [6][7][8] For the assessment of the constitution and organization of healthy articular cartilage as well as cartilage repair tissue, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and the mapping of transverse relaxation times (T2-mapping) are most often utilized. Whereas the dGEMRIC technique can visualize the glycosaminoglycan (GAG) component of articular cartilage, T2 mapping focuses on changes in water and collagen content and tissue anisotropy.…”

mentioning

confidence: 99%

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Welsch

Mamisch

Marlovits

et al. 2009

Journal Orthopaedic Research

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The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of cartilage repair tissue maturation after matrix-associated autologous chondrocyte transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 AE 12.1 months after cartilage transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 AE 12.0 months after surgery), a longitudinal 1-year followup MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steadystate sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the cartilage repair area and in control cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy cartilage and cartilage repair tissue (p < 0.05). Using zonal T2 evaluation, healthy cartilage showed a significant increase from the deep to superficial cartilage layers (p < 0.05). Cartilage repair tissue after MACT showed no significant zonal increase from deep to superficial cartilage areas during baseline MRI (p > 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of cartilage repair tissue. ß

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Three‐dimensional delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix‐associated autologous chondrocyte transplantation at 3.0T: Preliminary results

Cited by 148 publications

References 40 publications

Delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in Femoacetabular impingement

Delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in Femoacetabular impingement

Feasibility of T mapping for the evaluation of hip joint cartilage at 1.5T using a three‐dimensional (3D), gradient‐echo (GRE) sequence: A prospective study

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

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