Three-dimensional Conformal Radiotherapy for Esophageal Carcinoma

Wang, L.; Han, Chun; Chi, Z

doi:10.1016/j.ijrobp.2008.06.1392

Cited by 2 publications

(2 citation statements)

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“…In this study, to clarify the impact of the length of the esophageal lesions on the survival rate of patients, we applied the ROC curve analysis method to define the specific cut-off values of the patients in this group. The results show that when the patient's lesion length is ≤4.5 cm, the patient survival rate, and local control rate are better than those patients with esophageal lesion length > 4.5 cm, which is similar to the results reported in the past [8] [9] [10] [11] [12].…”

Section: Discussionsupporting

confidence: 84%

Impact and Analysis of Prognostic Factors in Patients with Non-Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Single Institution Study

Keita,

Bah,

Koundouno

et al. 2021

OJIM

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Objective: To investigate the impact of local tumor factors on the prognosis of non-metastatic esophageal squamous cell carcinoma patients. Methods: We performed a retrospective analysis of data from 278 consecutive esophageal squamous cell carcinoma patients between January 2009 and December 2016. The prognosis factors such as the GTV volume, GTV maximum diameter, and GTV length were analyzed. Results: The results of ROC curve analysis showed that prognosis critical values of the GTV volume, GTV maximum diameter, and GTV length were 27.98 cm 3 , 1.80 and 5.85 cm, respectively. The result of the univariate analysis showed that the GTV volume (P = 0.0184), GTV maximum diameter (P = 0.0246), and GTV length (P = 0.0035) were the prognostic factors for overall survival; the barium meal length (P = 0.0149) was the prognostic factor for local control. The multivariate analysis showed that the barium meal length (P = 0.0013), GTV maximum diameter (P = 0.0047), and GTV length (P = 0.0032) as the independent prognostic factors associated with overall survival; the barium meal length (P = 0.0037) was the only independent prognostic factors for local control. Conclusion: The esophageal lesion length was the main prognosis factor for patients with non-metastatic esophageal squamous cell carcinoma. Therefore, we suggest that the physician must give enough attention to these patients in clinical practice, and give active treatment.

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Section: Discussionsupporting

confidence: 84%

Impact and Analysis of Prognostic Factors in Patients with Non-Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Single Institution Study

Keita,

Bah,

Koundouno

et al. 2021

OJIM

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“…Several studies have shown that the incidence and severity of radiation pneumonia were related to the irradiation to normal lung tissue in esophageal carcinoma radiotherapy. For instance, Wang et al [4] found that, among 100 patients, 49% of them have developed various severity pneumonia, in whom 27% have grade 1, 16% have grade 2, 6% have grade 3 pneumonia. From a clinical aspect, decreasing the side effect of radiotherapy is another way to improve the survival rate.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric Study of Coplanar and Non-Coplanar Intensity-Modulated Radiation Therapy Planning for Esophageal Carcinoma

Li¹,

Liu²,

Zhai³

et al. 2013

IJMPCERO

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Purpose: To compare the dosimetric impact of coplanar intensity modulated radiation therapy (IMRT) and non-coplanar IMRT for the esophageal carcinoma. Methods: There are forty-five esophageal carcinoma patients, fifteen of whom were cervical and upper thoracic (Group 1) and thirty were middle and lower thoracic (Group 2). Gross tumor volume (GTV), clinical target volume (CTV), and organs at risk (OAR) were contoured by the chief physician in the CMS-XiO treatment planning system. For each patient, one coplanar plan and two non-coplanar plans have been created using the same physical objective function. A detailed dose-volume histogram (DVH) comparison among three plans was then carried out in a tabulated format. Results: 1) In Group 1 patients with PTV volume less than 100cc, the mean dose and dose gradient of non-coplanar plan were much better than those in coplanar plan. 2) In Group 2 patients, the conformity index (CI) for coplanar and two non-coplanar plans were 0.69 ± 0.13, 0.41 ± 0.13, and 0.68 ± 0.15, respectively. The V5, V10, V20, and the mean dose to the lung were lower in the non-coplanar plans compared to ones in coplanar plan. However, the non-coplanar plans resulted in an increase in a dose to the heart, but the dose was still within heart toxicity tolerance. Conclusion: For Group 1 patients, the non-coplanar IMRT plan had less dose gradient and better mean dose than the coplanar IMRT plan. For Group 2 patients, the non-coplanar IMRT could the decrease dose to the lung tissue, thus lowering the probability of radiation pneumonia to esophageal cancer patients. The drawback of non-coplanar IMRT is that, even within toxicity tolerance, it could deliver a higher dose to the heart and spinal cord compared to the coplanar plan. Therefore, for patients with cardiology and neurology concern, non-coplanar IMRT should be used with caution.

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Three-dimensional Conformal Radiotherapy for Esophageal Carcinoma

Cited by 2 publications

References 0 publications

Impact and Analysis of Prognostic Factors in Patients with Non-Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Single Institution Study

Impact and Analysis of Prognostic Factors in Patients with Non-Metastatic Esophageal Squamous Cell Carcinoma: A Retrospective Single Institution Study

Dosimetric Study of Coplanar and Non-Coplanar Intensity-Modulated Radiation Therapy Planning for Esophageal Carcinoma

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