Three‐dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs

Mori, Takashi; Ito, Yusuke; Kawabe, Mifumi; Iwasaki, Ryota; Sakai, Hiroki; Murakami, Mami; Maruo, Keishi

doi:10.1111/jsap.12352

Cited by 17 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Primary and secondary hepatic neoplasia occurs in dogs and in some cases are considered nonresectable, or circumstances may exist that preclude certain treatments . Treatment of nonresectable canine hepatic tumors is typically limited but may include chemotherapy, embolization, or radiation therapy . In addition, with neoplasms such as hemangiosarcoma, a large tumor burden may limit the efficacy of chemotherapy and may place dogs at greater risk for spontaneous hepatic hemorrhage and death …”

Section: Introductionmentioning

confidence: 99%

Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia

et al. 2019

View full text Add to dashboard Cite

Objective: To determine laparoscopic accessibility of liver lobes and access to the hilus and describe laparoscopic microwave ablation (LMWA) in 2 dogs with hepatic neoplasia. Study design: Experimental/descriptive case series. Sample population: Six canine cadavers and 2 clinical dogs. Methods: Cadavers in dorsal recumbency underwent laparoscopic assessment of the liver. A 17 gauge MWA probe was inserted to create an ablation zone at the most proximal aspect of the hilus. The distance from the center of each ablation zone to the most proximal aspect of the corresponding hilus was determined. Two dogs with hepatic neoplasia underwent LMWA. Results: All lobes of the canine liver were accessible via laparoscopy. The median (interquartile range) distances from the ablation zones to the hilus for the caudate process, left lateral, left middle, quadrate, right lateral, and right middle lobes were 2.

show abstract

Section: Introductionmentioning

confidence: 99%

Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A well-designed radiotherapy program is intended and designed to maximize tumor effect and minimize normal tissue effect. The benefit of radiotherapy is a cure for tumors and a split course treatment before surgery or chemotherapy [17]. The alternative approach to the above "targeted instrumental and drug invasion into the injured body part" is the overall improvement of the whole body and emotional well-being of a patient.…”

Section: Definition Of Critical Terminologymentioning

confidence: 99%

“…A 3D-CRT (three-dimensional conformal radiation therapy) is introduced as a new viable treatment option for canine patients with an inoperable massive liver carcinoma. From 6 to 10 Gy per fraction are prescribed on the planning target volume, and the total dose is 18-42 Gy with 1 to 2 fractions per week [17].…”

Section: Background Review and Rationale Study With Referencementioning

confidence: 99%

Canine Hepatic Carcinoma: Diagnoses and Treatments Via Global State-of-the-Art Approach and Traditional Chinese Veterinary Medicine

Chen¹,

Chiu²,

Pan³

et al. 2021

Canine Genetics, Health and Medicine

View full text Add to dashboard Cite

This chapter discusses effective diagnostics and treatment of canine hepatic carcinoma (CHC), where state-of-the-art global technologies are complemented by traditional Chinese veterinary medicine (TCVM). The biokinetic Ga-67 model of CHC is proposed to clarify the Ga-67 metabolic mechanism among various organs. It is aimed at identifying the best routine for detecting the metastatic or primary CHC and substantiating the optimal further treatment. The routine examination of CHC can be performed via Ga-67 nuclear examination or MRI, biological index, X-ray, and abdominal ultrasound. The available methods of animal cancer treatment imply separate or combined application of surgery, radiation therapy, and chemotherapy targeted at the particular cancer cells. However, there is also a general concern on the quality of life of pets/canine patients. This leaves enough space to the TCVM (including acupuncture and famous herbal drugs) with a long application history in Asia and growing usage as alternative treatment in other regions. However, its current applications to domestic animals/pets suffering from carcinomas are based on individual expert opinions, while there are no outlined veterinary treatment strategies and guidelines for clinical practice in this field. A comprehensive combination of state-of-the-art global technologies and TCVM is considered instrumental in curing canine hepatic carcinoma.

show abstract

“…In those cases where primary and secondary hepatic neoplasms in dogs are deemed non-resectable, alternative treatment options may include radiation therapy, chemoembolisation, bland embolisation or chemotherapy although hepatic carcinomas appear to be intrinsically resistant to cytotoxic drugs (Weisse 2009, Elpiner et al 2011, Mori et al 2015. Another potential treatment option is MWA.…”

Section: Introductionmentioning

confidence: 99%

Percutaneous ultrasound‐guided microwave ablation for treatment of hepatocellular carcinomas in dogs: four cases (2019‐2020)

Locatelli¹,

Treggiari²,

Innocenti³

et al. 2022

J of Small Animal Practice

View full text Add to dashboard Cite

Objectives To describe ultrasound‐guided microwave ablation as a minimally invasive treatment option for primary or metastatic hepatocellular carcinomas. Methods Four client‐owned dogs underwent percutaneous ultrasound‐guided microwave ablation of three primary and one metastatic hepatocellular carcinoma, diagnosed on cytology/histopathology. In each case, multiple ultrasound‐guided thermal lesions were created in a 10 to 40 minutes ablation at 30 to 35 W. Real‐time monitoring was performed using 10 MHz diagnostic ultrasound transducers. The procedures were performed without complication and CT scans or abdominal ultrasounds were repeated immediately after. Patients were discharged on oral analgesia on the same day or 24 hours later. Results Hepatocellular carcinomas were successfully ablated, which in some cases resulted in an improvement in clinical signs and laboratory values. The patients were followed up for a time ranging between 39 and 649 days and no evidence of disease progression was found. Three out of four patients are still alive at the time of writing. Clinical Significance In these four patients, minimally invasive ultrasound‐guided microwave ablation was feasible and resulted in no immediate complications. Regular imaging follow‐up is recommended after the procedure and further studies on microwave ablation are warranted to establish its effectiveness in dogs with hepatocellular carcinomas.

show abstract

Three‐dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs

Abstract: 3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.

Cited by 17 publications

References 28 publications

Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia

Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia

Canine Hepatic Carcinoma: Diagnoses and Treatments Via Global State-of-the-Art Approach and Traditional Chinese Veterinary Medicine

Percutaneous ultrasound‐guided microwave ablation for treatment of hepatocellular carcinomas in dogs: four cases (2019‐2020)

Contact Info

Product

Resources

About