Three-dimensional condylar displacement and remodelling following correction of asymmetric mandibular prognathism with maxillary canting

Abotaleb, Bassam; Bi, Ruiye; Jiang, Nan; Ye, B.; Bai, Yuanyan; Al‐Watary, Mohammed Qasem

doi:10.1016/j.ijom.2021.12.003

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Endotracheal intubation has been proposed as a risk factor for TMD, with symptoms resulting from forces applied with the laryngoscope or manually to complete the intubation and possibly being related to the duration of temporomandibular joint (TMJ) loading stresses during orthognathic surgery [62]. Higher preoperative asymmetry was significantly correlated with increased postoperative condylar displacement with vertical asymmetry and condylar displacement was associated with the resulting remodeling process, which may affect long-term surgical stability [63].…”

Section: Discussionmentioning

confidence: 99%

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Andreucci

2024

Osteology

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Craniofacial surgery is proposed and performed for a variety of reasons, ranging from congenital or acquired malformations to emotional disorders and parafunctions of the masticatory, respiratory, auditory, and visual systems. Surgery of the mandible and its orthostatic repositioning is the most common of these corrections of craniofacial anomalies. Throughout the history of these procedures, various techniques have been proposed and perfected, but always with a high rate of minor and major complications. The recurrence rate of mandibular malposition is high, as is the temporary loss of facial sensitivity and motor skills. These outcomes are often related to the choice of surgical technique rather than the skill of the surgeon, which is considered to be one of the most important factors in the final outcome. Surgical techniques involving direct manipulation of the vascular-nervous bundles, such as bilateral sagittal split osteotomy, clearly present the possibility of major or minor complications. In this study, an orthognathic surgical technique, performed by the same team for over 40 years and now available through a 20-year postoperative patient follow-up study, is presented with a literature review relating it to biomechanical concepts and bone remodeling to analyze the evolution of orthognathic surgery since it became common practice to correct maxillofacial discrepancies. In this review, we also present a case report in which previous orthodontic treatment prepared a patient for surgical correction of mandibular bone discrepancy without the need for combined maxillary and/or genioplasty, and we describe the most commonly used techniques today, as well as their advantages and disadvantages. The combination of established concepts together promotes favorable stability of mandibular osteotomies, functional anatomical positioning of the temporomandibular joint, reduced risk of injury to the mandibular vasculo-nervous bundle, and good aesthetics with positive patient acceptance and no relapse, thus these are the objectives for proposing innovative treatments that combine the technologies available today.

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Section: Discussionmentioning

confidence: 99%

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Andreucci

2024

Osteology

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“…[5] Notably, the SPP1 gene has been identified as a significant biomarker in hypopharyngeal SCC, [6] with its upregulated mRNA expression in tumor tissues correlating with poor overall survival of hypopharyngeal SCC patients. [7] Additionally, its role in promoting lymph node metastasis (LNM) in hypopharyngeal SCC has been proposed. [8] Analysis of large public datasets [9] suggested the role of interactions, SPP1-CD44 and SPP1-ITGB1, in hypopharyngeal SCC progression.…”

Section: Among the Interactions Spp1 Ligand-mediated Interactions (Sp...mentioning

confidence: 99%

Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role ofSPP1⁺macrophages

Ohn,

Bae,

Choi

et al. 2024

Preprint

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Hypopharyngeal squamous cell carcinoma (SCC) is a highly aggressive cancer with a poor prognosis, particularly in advanced stages where concurrent chemoradiotherapy (CCRT) is used for treatment. However, resistance to CCRT poses a significant challenge, often leading to treatment failure and disease progression. This study explores the tumor microenvironment (TME) of hypopharyngeal SCC to understand the molecular mechanisms underlying CCRT resistance. Using spatial transcriptomics (ST), we analyzed tissue samples from patients with locally advanced hypopharyngeal SCC, distinguishing between those who were CCRT-resistant and those who were CCRT-naive. The analysis revealed six distinct cellular clusters within the TME, including a prominent epithelio-immune cellular area in CCRT-resistant tissues. SPP1 was identified as a key gene with significantly higher expression in CCRT-resistant samples, specifically within macrophages. Further investigation showed that SPP1+ macrophages interacted with malignant epithelial cells through SPP1-CD44 and SPP1-ITGB1 ligand-receptor pairs. These interactions were primarily localized in the peri-tumoral and intra-tumoral regions, highlighting their potential role in driving CCRT resistance. Our findings suggest that SPP1+ macrophages contribute to the resistant phenotype in hypopharyngeal SCC by modulating the TME and interacting with cancer cells. Understanding these interactions offers valuable insights into the mechanisms of CCRT resistance and may inform the development of targeted therapies to improve patient outcomes.

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Early and 1-year postsurgical stability and its factors in patients with complicated skeletal Class Ⅲ malocclusion treated by conventional and surgery-first approach: A prospective cohort study

Jiang

Zhong-peng

et al. 2023

American Journal of Orthodontics and Dentofacial Orthopedics

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Three-dimensional condylar displacement and remodelling following correction of asymmetric mandibular prognathism with maxillary canting

Cited by 6 publications

References 38 publications

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role ofSPP1⁺macrophages

Early and 1-year postsurgical stability and its factors in patients with complicated skeletal Class Ⅲ malocclusion treated by conventional and surgery-first approach: A prospective cohort study

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Three-dimensional condylar displacement and remodelling following correction of asymmetric mandibular prognathism with maxillary canting

Cited by 6 publications

References 38 publications

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Sixty Years of Innovation in Biomechanical Orthognathic Surgery: The State of the Art and Future Directions

Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role ofSPP1+macrophages

Early and 1-year postsurgical stability and its factors in patients with complicated skeletal Class Ⅲ malocclusion treated by conventional and surgery-first approach: A prospective cohort study

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Spatial transcriptomics unveils landscape of resistance to concurrent chemo-radiotherapy in hypopharyngeal squamous cell carcinoma: the role ofSPP1⁺macrophages