In this work, we present a computational investigation of the thermodynamic irreversibilities generated by the combustion process in a cylindrical combustor. The calculations of the turbulent non-premixed combustion properties are based on the aerothermochemical equations. The simulation considers the contribution of each mechanism in the entropy generation sources, i.e., friction, heat conduction, species diffusion and chemical reaction. The computations were carried out by the Fluent-CFD software package. The results show that the chemical reaction and the heat conduction are the major sources of entropy production. Moreover, the fuel preheating reduces significantly thermodynamic irreversibilities in the combustion chamber, while the air factor has a negative effect.