Three-dimensional changes in regional right ventricular curvature and function in tetralogy of fallot

Cossor, Waseem; Maffessanti, Francesco; Addetia, Karima; Mor‐Avi, Victor; Kawaji, Keigo; Roberson, David A.; Dill, Karin E.; Varga, Péter; Lang, Roberto M.; Patel, Amit R.

doi:10.1186/1532-429x-17-s1-p214

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“…In the 3D volume, the total volume was calculated as the sum of all identified voxel. A custom tool built in Matlab (The Mathworks Inc. Natick, MA) was used for additional visualization of the RV patch geometry (17). A semi-automated, threshold detection using standard region-growth was incorporated for scar volume quantification (where a standard ±5 std region-of-interest (ROI) signal intensity cut-off) was also employed in this reformatted geometry for algorithmic refinement/validation of the manually delineated ROI measurements.…”

Section: Methodsmentioning

confidence: 99%

3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profile/view ordering: Feasibility of right ventricular myocardial damage assessment using a swine animal model

Kawaji

Tanaka

Patel

et al. 2017

Magnetic Resonance Imaging

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Aims To develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV). Methods and Results A k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac patch implantation in the RV, followed in 60 days by 1.5 T MRI. LGE with Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP- LGE with slice-tracking. The animal heart was excised immediately after cardiac MR for scar volume quantification. RV scar volumes were also delineated from the 2DBH and 3DFB-CP-LGE images for comparison against the surgical standard. Apparent scar/normal tissue signal-to-noise ratio (aSNR) and contrast-to-noise ratio (aCNR) were also calculated. 3DFB-CP-LGE technique was successfully performed in all animals. No difference in aCNR was noted, but aSNR was significantly higher using the 3D technique (p<0.05). Against the surgical reference volume, the 3DFB-CP-LGE-derived delineation yielded significantly less volume quantification error compared to 2DBH-derived volumes (15±10% vs 55±33%; p<0.05). Conclusion Compared to conventional 2DBH-LGE, 3DFB-LGE acquisition using CENTRA-PLUS provided superior scar volume quantification and improved aSNR.

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Section: Methodsmentioning

confidence: 99%