Three-Dimensional Architecture of Cardiomyocytes and Connective Tissues in Hypertrophic Cardiomyopathy

Kanzaki, Yumiko; Yamauchi, Yohei; Okabe, Makoto; Terasaki, Fumio; Ishizaka, Nobukazu

doi:10.1161/circulationaha.111.054668

Cited by 15 publications

(12 citation statements)

References 4 publications

(2 reference statements)

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“…CMs in the healthy adult heart are elongated and rod‐shaped and changes in their shape are concurrent with whole heart changes in diseased states such as cardiomyopathy and heart failure (Gerdes & Capasso, ; Kanzaki et al . ). Yet CMs that have lost their native shape are a central tenant of mechanistic research in vitro .…”

Section: Introductionmentioning

confidence: 97%

In vitro models of the cardiac microenvironment to study myocyte and non‐myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

Kofron

Mende

2017

The Journal of Physiology

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The heart is a complex pluricellular organ composed of cardiomyocytes and non-myocytes including fibroblasts, endothelial cells and immune cells. Myocytes are responsible for electrical conduction and contractile force generation, while the other cell types are responsible for matrix deposition, vascularization, and injury response. Myocytes and non-myocytes are known to communicate and exert mutual regulatory effects. In concert, they determine the structural, electrical and mechanical characteristics in the healthy and remodelled myocardium. Dynamic crosstalk between myocytes and non-myocytes plays a crucial role in stress/injury-induced hypertrophy and fibrosis development that can ultimately lead to heart failure and arrhythmias. Investigations of heterocellular communication in the myocardium are hampered by the intricate interspersion of the different cell types and the complexity of the tissue architecture. In vitro models have facilitated investigations of cardiac cells in a direct and controllable manner and have provided important functional and mechanistic insights. However, these cultures often lack regulatory input from the other cell types as well as additional topographical, electrical, mechanical and biochemical cues from the cardiac microenvironment that all contribute to modulating cell differentiation, maturation, alignment, function and survival. Advancements in the development of more complex pluricellular physiological platforms that incorporate diverse cues from the myocardial microenvironment are expected to lead to more physiologically relevant cardiac tissue-like in vitro models for mechanistic biological research, disease modelling, therapeutic target identification, drug testing and regeneration.

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Section: Introductionmentioning

confidence: 97%

In vitro models of the cardiac microenvironment to study myocyte and non‐myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

Kofron

Mende

2017

The Journal of Physiology

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“…septal) or diffuse hypertrophy of the myocardium, which is not associated with increased pressure loading; it can be associated with a wide range of different underlying alterations in the contractile apparatus of the myocyte [25]. Histologically, in HCM there is a characteristic loss of the usual highly ordered local myocyte orientation seen in normal hearts [26]. There is also an increase in the amount of collagen in the heart wall, especially around blood vessels [26].…”

Section: Imaging Myocardial Microstructurementioning

confidence: 99%

“…Histologically, in HCM there is a characteristic loss of the usual highly ordered local myocyte orientation seen in normal hearts [26]. There is also an increase in the amount of collagen in the heart wall, especially around blood vessels [26]. HCM patients may also develop local fibrosis within areas of hypertrophy, which can be seen as corresponding local areas of abnormal late gadolinium enhancement; these areas of fibrosis may be associated with an increased risk of arrhythmias [27].…”

Section: Imaging Myocardial Microstructurementioning

confidence: 99%

Probing dynamic myocardial microstructure with cardiac magnetic resonance diffusion tensor imaging

Axel

Wedeen

Ennis

2014

Journal of Cardiovascular Magnetic Resonance

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“…The most abundant collagen type present in the LV is type I, which represents 70% of the total cardiac collagen [45]. Collagen fibers form a complex network to provide strength sufficient to support the three-dimensional structure surrounding cardiac muscle fibers and neighboring vascular tissues [46]. These fibers prevent excessive cardiomyocyte stretching due to the elastic energy that is saved during myocardial contraction.…”

Section: LV Remodeling Following Mimentioning

confidence: 99%

Matrix Metalloproteinases: Drug Targets for Myocardial Infarction

Yabluchanskiy¹,

Li²,

Chilton³

et al. 2013

Current Drug Targets

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Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Rapid advances in the treatment of acute MI have significantly improved short-term outcomes in patient, due in large part to successes in preventing myocardial cell death and limiting infarct area during the time of ischemia and subsequent reperfusion. Matrix metalloproteases (MMPs) play key roles in post-MI cardiac remodeling and in the development of adverse outcomes. This review highlights the importance of MMPs in the injury and remodeling response of the left ventricle and also discusses their potential as therapeutic targets Additional pre-clinical and clinical research is needed to further investigate and understand the cardioprotective effects of MMPs inhibitors.

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Three-Dimensional Architecture of Cardiomyocytes and Connective Tissues in Hypertrophic Cardiomyopathy

Cited by 15 publications

References 4 publications

In vitro models of the cardiac microenvironment to study myocyte and non‐myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

In vitro models of the cardiac microenvironment to study myocyte and non‐myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

Probing dynamic myocardial microstructure with cardiac magnetic resonance diffusion tensor imaging

Matrix Metalloproteinases: Drug Targets for Myocardial Infarction

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