Three dimensional anatomy of the human nucleus accumbens

Neto, Lia Lucas; Neto, Daniel; Oliveira, Edson; Martins, Hugo; Mourato, B.; Correia, Francisco; Rainha-Campos, A.; Gonçalves-Ferreira, António

doi:10.1007/s00701-013-1820-z

Cited by 15 publications

(13 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous reports concerning the stereotaxy and 3D anatomical reconstruction of the human Acc we have also used that reference, which is widely accepted as the Acc posterior limit. However, one of the features observed at that time was the increase in the variability and shape of the nucleus at its most posterior part, with larger values of width and height than were expected for a structure that was ending at that level [23,24,27]. Additionally, we have found in recent observations that the Acc could well extend somewhat beyond the AC [56,57,58].…”

Section: Discussionmentioning

confidence: 93%

“…The slices incubated with anti-D1 and anti-D2 receptors were digitized in a fluorescence microscope (Leica DM2000). The slices were analyzed concerning the histology and cellular organization at the following three levels: level A - corresponding to the posterior part of the Acc, as detailed elsewhere [23,24,27], approximately 5 mm ahead of the AC; level B - corresponding to the subcommissural part of the Acc, where the AC is a continuous structure in the coronal plane, and level C - approximately 2 mm after the interruption of the AC, corresponding to the postcommissural septal area (fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…This issue can only be addressed with further histological studies in postmortem human brain tissue [21,22]. In previous works our group studied the anatomy and histology of the human Acc and established its stereotactic coordinates and 3D anatomical model [23,24]. However, it was always difficult to establish precisely its posterior margin.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Nucleus Accumbens beyond the Anterior Commissure: Implications for Psychosurgery

Neto¹,

Mourato²,

Neto³

et al. 2014

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Introduction: The nucleus accumbens (Acc) is a basal forebrain structure integrated in the dopaminergic cerebral rewarding circuits and implicated in some neuropsychiatric disorders. It has become a target for deep brain stimulation for some of these disorders when refractory to medical treatment. However, it is controversial as to which target is the best and similar results have been achieved with the stimulation of neighboring structures such as the bed nucleus of the stria terminalis (BNST). Previous studies have established the stereotactic anatomy of the human Acc, but some difficulties remain concerning its precise posterior limit, which is assumed to be at the level of the anterior commissure (AC). It is our purpose to clarify the anatomy of this zone, given the importance of its exact identification in psychosurgery. Methods: A total of 16 Acc were collected by autopsy, fixed, dissected, embedded and cut in coronal 5-µm slices. The slices were stained with hematoxylin and eosin, marked with anti-D1 and anti-D2 antibodies and analyzed under a microscope. Results: The human Acc has the same cellular structure as the dorsal striatum, except in its posterior subcommissural part where voluminous neurons prevail, similar to and contiguous with the BNST. Conclusions: The Acc is longer than previously described, with a sub- and postcommissural extension behind the AC, continuous with the BNST.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Nucleus Accumbens beyond the Anterior Commissure: Implications for Psychosurgery

Neto¹,

Mourato²,

Neto³

et al. 2014

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

show abstract

“…The accumbens nucleus and caudate nucleus seemed to be relatively spared bilaterally on the PETscan images (Lucas-Neto et al, 2013). Basal ganglia pathways are involved in decision-making, which requires estimating reward prediction errors, selecting/amplifying the most rewarding decision, and learning to improve future decisionmaking.…”

Section: Discussionmentioning

confidence: 99%

Ganser-like Syndrome After Loss of Psychic Self-activation Syndrome: Psychogenic or Organic?

Kaphan¹,

Barbeau

Royère

et al. 2014

Archives of Clinical Neuropsychology

View full text Add to dashboard Cite

Very few data are available on the long-term changes in the cognitive abilities of patients with loss of psychic self-activation syndrome (LPSAS). Here, we present a 25-year follow-up study on a case of LPSAS resulting from bilateral pallidal lesions caused by carbon monoxide intoxication. Typical signs of LPSAS were observed, showing no changes in severity, but Ganser syndrome (GS) gradually developed and worsened during the follow-up period. GS is generally assumed to be a psychogenic syndrome, but an organic etiology has been suspected by the authors of several case reports. Here, atypical features of GS plead against the independence of GS and LPSAS. DaTSCAN and brain 18FDG-PET were performed. Since left hippocampal hypometabolism has been previously described in patients with functional amnesia, it is possible that long periods of mental inactivity may have psychological consequences, but the atypical features of GS also suggest that an organic mechanism may be involved.

show abstract

“…Thus, a 3-mm contact length combined with a 2-mm contact interval should completely cover the NAc (14,15). Moreover, under the same stimulation parameters, the electric field distribution increases as the electrode contact length increases, such that a larger contact interval enables a greater electric field distribution.…”

Section: The Sceneray 1242 Electrodementioning

confidence: 97%

Target-specific deep brain stimulation of the ventral capsule/ventral striatum for the treatment of neuropsychiatric disease

Zhang

Jin

et al. 2017

Annals of Translational Medicine

View full text Add to dashboard Cite

Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC). This VC/VS-specific electrode has the potential to enhance stimulus intensity, provide independent and flexible target stimulation.

show abstract

Three dimensional anatomy of the human nucleus accumbens

Abstract: This study defined more accurately the 3D anatomy of the human Acc, providing new tools for stereotactic procedures.

Cited by 15 publications

References 48 publications

The Nucleus Accumbens beyond the Anterior Commissure: Implications for Psychosurgery

The Nucleus Accumbens beyond the Anterior Commissure: Implications for Psychosurgery

Ganser-like Syndrome After Loss of Psychic Self-activation Syndrome: Psychogenic or Organic?

Target-specific deep brain stimulation of the ventral capsule/ventral striatum for the treatment of neuropsychiatric disease

Contact Info

Product

Resources

About