Three-Dimensional Analysis of Choroidal Vessels in the Eyes of Patients With Unilateral BRVO

Chen, Lulu; Yuan, Mingzhen; Sun, Lu; Chen, Youxin

doi:10.3389/fmed.2022.854184

Cited by 9 publications

(7 citation statements)

References 31 publications

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“… 9 , 42 , 43 Nevertheless, other studies found similar CC-VFD in CRVO and BRVO eyes compared to their respective fellow eyes. 15 , 44 In our analysis using UWF-SS-OCTA, no differences were observed in CC-VFD in ischemic CRVO and BRVO eyes compared to their fellow eyes and control eyes. Although the reasons for the discordant findings regarding the choroid in RVO among these various studies are not well understood, we speculate that differences in gender, axial length, type and stage of RVO, and RVO-associated complications such as ME may play a role.…”

Section: Discussionmentioning

confidence: 58%

Central and Peripheral Changes in Retinal Vein Occlusion and Fellow Eyes in Ultra-Widefield Optical Coherence Tomography Angiography

Zhao,

Wang

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To explore the central and peripheral retinal and choroidal changes in retinal vein occlusion (RVO) and fellow eyes using ultra-widefield swept-source optical coherence tomography angiography (UWF-SS-OCTA). Methods Fifteen ischemic central RVO (CRVO), 15 branch RVO (BRVO), and 15 age-matched healthy controls were prospectively recruited. Retinal and choroidal parameters, including retinal vessel flow density (VFD) and vessel linear density (VLD), choroidal vascularity volume (CVV), choroidal vascularity index (CVI), and VFD in the large and medium choroidal vessels (LMCV-VFD), were measured in the central and peripheral regions of the 24 × 20-mm UWF-SS-OCTA images. Results Ischemic CRVO and BRVO eyes showed increased foveal avascular zone area, perimeter, and acircularity index (AI) compared to their fellow eyes and healthy control eyes, and RVO fellow eyes also had larger AI values than controls ( P < 0.05). For ischemic CRVO and BRVO eyes versus control eyes, VFD, VLD, CVV, CVI, and LMCV-VFD decreased, but retinal thickness and volume in the superficial capillary plexus, deep capillary plexus, and whole retina increased ( P < 0.05). Moreover, RVO fellow eyes also showed significantly decreased retinal VFD, LMCV-VFD, and CVI, as well as increased retinal thickness and volume, compared with control eyes ( P < 0.05). Alterations were not consistent throughout the retina, as they involved only the peripheral or central regions in some cases. Conclusions The affected and unaffected fellow eyes of RVO patients both demonstrated central and/or peripheral structural and vascular alterations in the retina and choroid. Because UWF-SS-OCTA enables visualization and evaluation of the vasculature outside the posterior pole, it presents a promising approach to more fully characterize vascular alterations in RVO.

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Section: Discussionmentioning

confidence: 58%

Central and Peripheral Changes in Retinal Vein Occlusion and Fellow Eyes in Ultra-Widefield Optical Coherence Tomography Angiography

Zhao,

Wang

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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“…As for the correlation analyses between 2D CVI and 3D CVI across various combinations of participant groups and time points, while 3D CVI has been used in the evaluation of choroidal angioarchitecture in nonuveitic diseases such as retinitis pigmentosa 18 , central serous chorioretinopathy 19, , branch retinal vein occlusion 21 , none of these published studies has studied the correlation between 2D subfoveal CVI and 3D volume CVI, let alone such a correlation in that of uveitis. Thus, to the best of our knowledge, our current study is the rst to reveal the correlation between 2D subfoveal CVI and 3D CVI in uveitis, and more broadly, any pathological state.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Agrawal,

Wei,

Loh

et al. 2024

Preprint

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Objectives To investigate longitudinal changes in choroidal vascularity index (CVI) in uveitis patients with active inflammation at baseline, and at six months. Methods This prospective comparative study included 49 eyes of 49 patients with anterior, intermediate, posterior or panuveitis, and 49 eyes of 49 healthy controls. Uveitis patients were recruited at baseline with active inflammation. Clinical data and multimodal imaging including optical coherence tomography were obtained at baseline and six months. Both two-dimensional (2D) subfoveal CVI and three-dimensional (3D) macular CVI were measured using previously published algorithms. Comparison between uveitis and control group as well as between baseline visit and 6 months visit in the uveitis group were performed using ANCOVA model. Results At baseline, 2D CVI was lower in the uveitis group (62.4% vs 63.8%, p = 0.007) and 3D CVI also showed a lower trend in the uveitis group (62.0% vs 62.8%, p = 0.109) compared to that of healthy subjects. Within the uveitis group, both 2D and 3D CVI were higher at 6 months compared to baseline, but both were not significant (p = 0.055 and 0.177, respectively). Uveitis patients who were still clinically active at 6 months had lower 2D and 3D CVI at baseline compared to those who were clinically quiescent at 6 months (p = 0.027 and p = 0.008, respectively). Conclusions Changes in CVI are correlated with the diagnosis and prognosis of uveitis patients. Lower CVI values at baseline were associated with persistent inflammation after 6 months of follow-up. Thus, CVI may be a useful outcome measure in uveitis management and clinical trials.

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“…However, B-scan is a single cross-sectional image and cannot fully reflect the overall vascular structure changes of the choroid. Some researchers have used B-scan images to form three-dimensional reconstructions of choroidal vessels for CVI calculation, which represents the volumetric choroidal density and may more comprehensively reflect the ratio of CVI in a particular region compared to cross-sectional images [ 42 ]. In the sub-analysis based on the study area, two studies [ 37 , 40 ] used the three-dimensional method, and WMD in this subgroup was lower than the macular subgroup ( Fig 8E ).…”

Section: Discussionmentioning

confidence: 99%

Choroidal vascularity index in different types of central serous chorioretinopathy: A meta-analysis

Xia¹,

Li²,

Zhang³

et al. 2023

PLoS ONE

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Purpose To evaluate the choroidal vascularity index (CVI) in different types of central serous chorioretinopathy (CSC), healthy control eyes, and fellow eyes. Methods Relevant studies published up to January 2023 were identified by searching multiple databases, including PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI). Studies investigating the difference in CVI between CSC and control eyes were included. Data from these studies were analyzed using Stata (version 17) software. Weighted mean difference (WMD) and 95% confidence interval (95%CI) were calculated for the CVI in CSC eyes, control eyes, and fellow eyes. Results The meta-analysis included 15 studies, with 213 acute CSC eyes, 153 chronic CSC eyes, 92 uncategorized CSC eyes, 40 resolved CSC eyes, 409 eyes of normal healthy controls, and 318 fellow eyes. The result revealed that CVI was higher in acute CSC eyes (WMD = 5.40, 95%CI = 2.36–8.44, P = 0.001) compared to control eyes. Also, CVI in chronic CSC eyes was higher than in control eyes (WMD = 1.26, 95%CI = 0.03–2.49, p = 0.046). The fellow eyes of acute CSC had a higher CVI when compared to control eyes (WMD = 2.53, 95%CI = 0.78–4.28, p = 0.005). There was no significant difference in CVI between acute and chronic CSC eyes (WMD = 0.75, 95%CI = -0.31–1.82, P = 0.167). In the sub-analysis based on the area selected for CVI calculation, the WMDs in the whole image subgroups were lower than the main analysis for the comparisons of fellow eyes of acute CSC and control eyes, acute CSC eyes and control eyes, and acute CSC eyes and fellow eyes. In the macular area subgroups, the WMDs were higher than in the whole image subgroups, suggesting a potential regional variation of CVI in CSC eyes. Conclusions The results demonstrated that CVI is increased in CSC eyes and fellow eyes of acute CSC. There is no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation can influence the outcome, which requires further clinical research to clarify.

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Three-Dimensional Analysis of Choroidal Vessels in the Eyes of Patients With Unilateral BRVO

Cited by 9 publications

References 31 publications

Central and Peripheral Changes in Retinal Vein Occlusion and Fellow Eyes in Ultra-Widefield Optical Coherence Tomography Angiography

Central and Peripheral Changes in Retinal Vein Occlusion and Fellow Eyes in Ultra-Widefield Optical Coherence Tomography Angiography

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Choroidal vascularity index in different types of central serous chorioretinopathy: A meta-analysis

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